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Filtros : "Cianni, Lorenzo" "MONTANARI, CARLOS ALBERTO" "IQSC" Removidos: "Prokopczyk, Igor Muccilo" "Committee of the International Congress of Pharmaceutical Sciences" Limpar

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  • Artigo de periodico

    Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L (2021)

    Cianni, Lorenzo ; Rocho, Fernanda dos Reis ; Bonatto, Vinícius ; Martins, Felipe Cardoso Prado ; Lameira, Jerônimo ; Leitão, Andrei ; Montanari, Carlos Alberto ; Shamim, Anwar

    Source: Bioorganic and Medicinal Chemistry. Unidade: IQSC

    Subjects: QUÍMICA MÉDICA, NEOPLASIAS, INIBIDORES DE ENZIMAS

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      CIANNI, Lorenzo et al. Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L. Bioorganic and Medicinal Chemistry, v. 29, p. 115827, 2021Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2020.115827. Acesso em: 05 nov. 2024.

    • APA

      Cianni, L., Rocho, F. dos R., Bonatto, V., Martins, F. C. P., Lameira, J., Leitão, A., et al. (2021). Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L. Bioorganic and Medicinal Chemistry, 29, 115827. doi:10.1016/j.bmc.2020.115827

    • NLM

      Cianni L, Rocho F dos R, Bonatto V, Martins FCP, Lameira J, Leitão A, Montanari CA, Shamim A. Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L [Internet]. Bioorganic and Medicinal Chemistry. 2021 ; 29 115827.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmc.2020.115827

    • Vancouver

      Cianni L, Rocho F dos R, Bonatto V, Martins FCP, Lameira J, Leitão A, Montanari CA, Shamim A. Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L [Internet]. Bioorganic and Medicinal Chemistry. 2021 ; 29 115827.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmc.2020.115827

  • Artigo de periodico

    The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro (2021)

    Botelho, Sabrina Mendes ; Rocho, Fernanda dos Reis ; Cianni, Lorenzo ; Montanari, Carlos Alberto ; Leitão, Andrei

    Source: Current Chemical Biology. Unidade: IQSC

    Subjects: CÉLULAS, ANTINEOPLÁSICOS, TERAPIA COMBINADA

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      BOTELHO, Sabrina Mendes et al. The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro. Current Chemical Biology, v. 15, n. 4, p. 278 - 286, 2021Tradução . . Disponível em: https://doi.org/10.2174/2212796815666211214111243. Acesso em: 05 nov. 2024.

    • APA

      Botelho, S. M., Rocho, F. dos R., Cianni, L., Montanari, C. A., & Leitão, A. (2021). The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro. Current Chemical Biology, 15( 4), 278 - 286. doi:10.2174/2212796815666211214111243

    • NLM

      Botelho SM, Rocho F dos R, Cianni L, Montanari CA, Leitão A. The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro [Internet]. Current Chemical Biology. 2021 ;15( 4): 278 - 286.[citado 2024 nov. 05 ] Available from: https://doi.org/10.2174/2212796815666211214111243

    • Vancouver

      Botelho SM, Rocho F dos R, Cianni L, Montanari CA, Leitão A. The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro [Internet]. Current Chemical Biology. 2021 ;15( 4): 278 - 286.[citado 2024 nov. 05 ] Available from: https://doi.org/10.2174/2212796815666211214111243

  • Artigo de periodico

    On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors (2020)

    Bonatt, Vinicius; Batista, Pedro Henrique Jatai ; Cianni, Lorenzo ; Vita, Daniela de ; Silva, Daniel G da; Cedron, Rodrigo; Tezuka, Daiane Yukie; Albuquerque, Sérgio de ; Moraes, Carolina Borsoi ; Franco, Caio Haddad ; Lameira, Jerônimo ; Leitão, Andrei ; Montanari, Carlos Alberto

    Source: RSC Medicinal Chemistry. Unidades: PUSP-RP, IQSC, BIOENGENHARIA

    Assunto: DOENÇA DE CHAGAS

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      BONATT, Vinicius et al. On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. RSC Medicinal Chemistry, v. 11, n. 11, p. 1275-1284, 2020Tradução . . Disponível em: https://doi.org/10.1039/D0MD00097C. Acesso em: 05 nov. 2024.

    • APA

      Bonatt, V., Batista, P. H. J., Cianni, L., Vita, D. de, Silva, D. G. da, Cedron, R., et al. (2020). On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. RSC Medicinal Chemistry, 11( 11), 1275-1284. doi:10.1039/D0MD00097C

    • NLM

      Bonatt V, Batista PHJ, Cianni L, Vita D de, Silva DG da, Cedron R, Tezuka DY, Albuquerque S de, Moraes CB, Franco CH, Lameira J, Leitão A, Montanari CA. On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors [Internet]. RSC Medicinal Chemistry. 2020 ; 11( 11): 1275-1284.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1039/D0MD00097C

    • Vancouver

      Bonatt V, Batista PHJ, Cianni L, Vita D de, Silva DG da, Cedron R, Tezuka DY, Albuquerque S de, Moraes CB, Franco CH, Lameira J, Leitão A, Montanari CA. On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors [Internet]. RSC Medicinal Chemistry. 2020 ; 11( 11): 1275-1284.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1039/D0MD00097C

  • Artigo de periodico

    Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment (2020)

    Albuquerque, Sérgio de ; Cianni, Lorenzo ; Vita, Daniela de ; Lopes, Carla Duque ; Gomes, Ana S. M.; Gomes, Paula; Laughton, Charles; Leitão, Andrei ; Montanari, Carlos Alberto ; Montanari, Raphael ; Ribeiro, Jean Francisco Rosa ; Silva, João Santana da ; Teixeira, Cátia

    Source: Chemical Biology & Drug Design. Unidades: FCFRP, IQSC, FMRP, EESC, ICMC

    Subjects: DOENÇA DE CHAGAS, TRYPANOSOMA CRUZI

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      ALBUQUERQUE, Sérgio de et al. Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment. Chemical Biology & Drug Design, v. 96, p. 948–960, 2020Tradução . . Disponível em: https://doi.org/10.1111/cbdd.13663. Acesso em: 05 nov. 2024.

    • APA

      Albuquerque, S. de, Cianni, L., Vita, D. de, Lopes, C. D., Gomes, A. S. M., Gomes, P., et al. (2020). Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment. Chemical Biology & Drug Design, 96, 948–960. doi:10.1111/cbdd.13663

    • NLM

      Albuquerque S de, Cianni L, Vita D de, Lopes CD, Gomes ASM, Gomes P, Laughton C, Leitão A, Montanari CA, Montanari R, Ribeiro JFR, Silva JS da, Teixeira C. Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment [Internet]. Chemical Biology & Drug Design. 2020 ; 96 948–960.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1111/cbdd.13663

    • Vancouver

      Albuquerque S de, Cianni L, Vita D de, Lopes CD, Gomes ASM, Gomes P, Laughton C, Leitão A, Montanari CA, Montanari R, Ribeiro JFR, Silva JS da, Teixeira C. Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment [Internet]. Chemical Biology & Drug Design. 2020 ; 96 948–960.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1111/cbdd.13663

  • Artigo de periodico

    Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents (2020)

    Cianni, Lorenzo ; Lemke, Carina; Gilberg, Erik; Feldmann, Christian; Rosini, Fabiana; Rocho, Fernanda dos Reis ; Ribeiro, Jean Francisco Rosa; Tezuka, Daiane Yukie; Lopes, Carla Duque ; Albuquerque, Sérgio de ; Bajorath, Jürgen; Laufer, Stefan; Leitão, Andrei ; Gütschow Michaell; Montanari, Carlos Alberto

    Source: PLoS Neglected Tropical Diseases. Unidades: IQSC, FCFRP, FMRP

    Assunto: QUÍMICA MÉDICA

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    • ABNT

      CIANNI, Lorenzo et al. Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents. PLoS Neglected Tropical Diseases, v. 14, n. 3, p. 1-36, 2020Tradução . . Disponível em: https://doi.org/10.1371/journal.pntd.0007755. Acesso em: 05 nov. 2024.

    • APA

      Cianni, L., Lemke, C., Gilberg, E., Feldmann, C., Rosini, F., Rocho, F. dos R., et al. (2020). Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents. PLoS Neglected Tropical Diseases, 14( 3), 1-36. doi:10.1371/journal.pntd.0007755

    • NLM

      Cianni L, Lemke C, Gilberg E, Feldmann C, Rosini F, Rocho F dos R, Ribeiro JFR, Tezuka DY, Lopes CD, Albuquerque S de, Bajorath J, Laufer S, Leitão A, Gütschow Michaell, Montanari CA. Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents [Internet]. PLoS Neglected Tropical Diseases. 2020 ; 14( 3): 1-36.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1371/journal.pntd.0007755

    • Vancouver

      Cianni L, Lemke C, Gilberg E, Feldmann C, Rosini F, Rocho F dos R, Ribeiro JFR, Tezuka DY, Lopes CD, Albuquerque S de, Bajorath J, Laufer S, Leitão A, Gütschow Michaell, Montanari CA. Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents [Internet]. PLoS Neglected Tropical Diseases. 2020 ; 14( 3): 1-36.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1371/journal.pntd.0007755

  • Artigo de periodico

    Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism (2020)

    Silva, JoséRogerio A.; Cianni, Lorenzo ; Araujo, Deborah; Batista, Pedro Henrique Jatai; Vita, Daniela de; Rosini, Fabiana; Leitão, Andrei ; Lameira, Jerônimo ; Montanari, Carlos Alberto

    Source: Journal of Chemical Information and Modeling. Unidade: IQSC

    Assunto: DOENÇA DE CHAGAS

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      SILVA, JoséRogerio A. et al. Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism. Journal of Chemical Information and Modeling, v. 60, n. 3, p. 1666-1677, 2020Tradução . . Disponível em: https://doi.org/10.1021/acs.jcim.9b01138. Acesso em: 05 nov. 2024.

    • APA

      Silva, J. R. A., Cianni, L., Araujo, D., Batista, P. H. J., Vita, D. de, Rosini, F., et al. (2020). Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism. Journal of Chemical Information and Modeling, 60( 3), 1666-1677. doi:10.1021/acs.jcim.9b01138

    • NLM

      Silva JRA, Cianni L, Araujo D, Batista PHJ, Vita D de, Rosini F, Leitão A, Lameira J, Montanari CA. Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism [Internet]. Journal of Chemical Information and Modeling. 2020 ; 60( 3): 1666-1677.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1021/acs.jcim.9b01138

    • Vancouver

      Silva JRA, Cianni L, Araujo D, Batista PHJ, Vita D de, Rosini F, Leitão A, Lameira J, Montanari CA. Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism [Internet]. Journal of Chemical Information and Modeling. 2020 ; 60( 3): 1666-1677.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1021/acs.jcim.9b01138

  • Artigo de periodico

    Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor (2020)

    Ribeiro, Jean Francisco Rosa ; Cianni, Lorenzo ; Li, Chan; Warwick, Thomas G.; Vita, Daniela de ; Rosini, Fabiana; Rocho, Fernanda dos Reis ; Martins, Felipe Cardoso Prado ; Kenny, Peter W; Lameira, Jerônimo ; Leitão, Andrei ; Emsley, Jonas ; Montanari, Carlos Alberto

    Source: Bioorganic and Medicinal Chemistry. Unidade: IQSC

    Subjects: LEISHMANIA MEXICANA, MEDICAMENTO

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      RIBEIRO, Jean Francisco Rosa et al. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor. Bioorganic and Medicinal Chemistry, v. 22, n. 22, p. 115743, 2020Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2020.115743. Acesso em: 05 nov. 2024.

    • APA

      Ribeiro, J. F. R., Cianni, L., Li, C., Warwick, T. G., Vita, D. de, Rosini, F., et al. (2020). Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor. Bioorganic and Medicinal Chemistry, 22( 22), 115743. doi:10.1016/j.bmc.2020.115743

    • NLM

      Ribeiro JFR, Cianni L, Li C, Warwick TG, Vita D de, Rosini F, Rocho F dos R, Martins FCP, Kenny PW, Lameira J, Leitão A, Emsley J, Montanari CA. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor [Internet]. Bioorganic and Medicinal Chemistry. 2020 ; 22( 22): 115743.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmc.2020.115743

    • Vancouver

      Ribeiro JFR, Cianni L, Li C, Warwick TG, Vita D de, Rosini F, Rocho F dos R, Martins FCP, Kenny PW, Lameira J, Leitão A, Emsley J, Montanari CA. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor [Internet]. Bioorganic and Medicinal Chemistry. 2020 ; 22( 22): 115743.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmc.2020.115743

  • Artigo de periodico

    Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases (2020)

    Cianni, Lorenzo ; Rocho, Fernanda dos Reis ; Rosini, Fabiana; Bonatto, Vinícius ; Ribeiro, Jean Francisco Rosa ; Lameira, Jerônimo ; Leitão, Andrei ; Shamim, Anwar ; Montanari, Carlos Alberto

    Source: Bioorganic Chemistry. Unidade: IQSC

    Subjects: FÁRMACOS, BIOMARCADORES, PROTEÍNAS

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      CIANNI, Lorenzo et al. Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases. Bioorganic Chemistry, v. 101, 2020Tradução . . Disponível em: https://doi.org/10.1016/j.bioorg.2020.104039. Acesso em: 05 nov. 2024.

    • APA

      Cianni, L., Rocho, F. dos R., Rosini, F., Bonatto, V., Ribeiro, J. F. R., Lameira, J., et al. (2020). Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases. Bioorganic Chemistry, 101. doi:10.1016/j.bioorg.2020.104039

    • NLM

      Cianni L, Rocho F dos R, Rosini F, Bonatto V, Ribeiro JFR, Lameira J, Leitão A, Shamim A, Montanari CA. Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases [Internet]. Bioorganic Chemistry. 2020 ; 101[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bioorg.2020.104039

    • Vancouver

      Cianni L, Rocho F dos R, Rosini F, Bonatto V, Ribeiro JFR, Lameira J, Leitão A, Shamim A, Montanari CA. Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases [Internet]. Bioorganic Chemistry. 2020 ; 101[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bioorg.2020.104039

  • Artigo de periodico

    N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization (2020)

    Lemke, Carina; Cianni, Lorenzo ; Feldmann, Christian; Gilberg, Erik; Yin, Jiafei; Rocho, Fernanda dos Reis ; Vita, Daniela de ; Bartz, Ulrike; Bajorath, Jürgen ; Montanari, Carlos Alberto ; Gütschow, Michael

    Source: Bioorganic & Medicinal Chemistry Letters. Unidade: IQSC

    Subjects: BIOQUÍMICA, PEPTÍDEOS, NITRILAS

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      LEMKE, Carina et al. N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization. Bioorganic & Medicinal Chemistry Letters, v. 30, 2020Tradução . . Disponível em: https://doi.org/10.1016/j.bmcl.2020.127420. Acesso em: 05 nov. 2024.

    • APA

      Lemke, C., Cianni, L., Feldmann, C., Gilberg, E., Yin, J., Rocho, F. dos R., et al. (2020). N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization. Bioorganic & Medicinal Chemistry Letters, 30. doi:10.1016/j.bmcl.2020.127420

    • NLM

      Lemke C, Cianni L, Feldmann C, Gilberg E, Yin J, Rocho F dos R, Vita D de, Bartz U, Bajorath J, Montanari CA, Gütschow M. N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization [Internet]. Bioorganic & Medicinal Chemistry Letters. 2020 ; 30[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmcl.2020.127420

    • Vancouver

      Lemke C, Cianni L, Feldmann C, Gilberg E, Yin J, Rocho F dos R, Vita D de, Bartz U, Bajorath J, Montanari CA, Gütschow M. N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization [Internet]. Bioorganic & Medicinal Chemistry Letters. 2020 ; 30[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmcl.2020.127420

  • Trabalho de evento-resumo

    Mapping the S1 and S1’ subsites of cysteine proteases for the synthesis of new dipeptidyl nitriles as trypanocidal agents (2019)

    Cianni, Lorenzo ; Montanari, Carlos Alberto

    Source: Book of Abstracts. Conference titles: The São Carlos Special Medicinal Chemistry Meeting - SancaMedChem2019. Unidade: IQSC

    Subjects: QUÍMICA MÉDICA, DOENÇA DE CHAGAS

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    • ABNT

      CIANNI, Lorenzo e MONTANARI, Carlos Alberto. Mapping the S1 and S1’ subsites of cysteine proteases for the synthesis of new dipeptidyl nitriles as trypanocidal agents. 2019, Anais.. São Paulo: Instituto de Química de São Carlos, IQSC, Universidade de São Paulo, USP, 2019. Disponível em: http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf. Acesso em: 05 nov. 2024.

    • APA

      Cianni, L., & Montanari, C. A. (2019). Mapping the S1 and S1’ subsites of cysteine proteases for the synthesis of new dipeptidyl nitriles as trypanocidal agents. In Book of Abstracts. São Paulo: Instituto de Química de São Carlos, IQSC, Universidade de São Paulo, USP. Recuperado de http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf

    • NLM

      Cianni L, Montanari CA. Mapping the S1 and S1’ subsites of cysteine proteases for the synthesis of new dipeptidyl nitriles as trypanocidal agents [Internet]. Book of Abstracts. 2019 ;[citado 2024 nov. 05 ] Available from: http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf

    • Vancouver

      Cianni L, Montanari CA. Mapping the S1 and S1’ subsites of cysteine proteases for the synthesis of new dipeptidyl nitriles as trypanocidal agents [Internet]. Book of Abstracts. 2019 ;[citado 2024 nov. 05 ] Available from: http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf

  • Artigo de periodico

    Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity? (2019)

    Cianni, Lorenzo ; Feldmann, CW; Gilberg, E; Gütschow Michaell; Juliano, Luiz; Leitão, Andrei ; Bajorath, Jurgen; Montanari, Carlos Alberto

    Source: Journal of Medicinal Chemistry. Unidade: IQSC

    Assunto: NEOPLASIAS

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      CIANNI, Lorenzo et al. Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?. Journal of Medicinal Chemistry, v. 62, n. 23, p. 10497-10525 july, 2019Tradução . . Disponível em: https://doi.org/10.1021/acs.jmedchem.9b00683. Acesso em: 05 nov. 2024.

    • APA

      Cianni, L., Feldmann, C. W., Gilberg, E., Gütschow Michaell,, Juliano, L., Leitão, A., et al. (2019). Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity? Journal of Medicinal Chemistry, 62( 23), 10497-10525 july. doi:10.1021/acs.jmedchem.9b00683

    • NLM

      Cianni L, Feldmann CW, Gilberg E, Gütschow Michaell, Juliano L, Leitão A, Bajorath J, Montanari CA. Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity? [Internet]. Journal of Medicinal Chemistry. 2019 ; 62( 23): 10497-10525 july.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1021/acs.jmedchem.9b00683

    • Vancouver

      Cianni L, Feldmann CW, Gilberg E, Gütschow Michaell, Juliano L, Leitão A, Bajorath J, Montanari CA. Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity? [Internet]. Journal of Medicinal Chemistry. 2019 ; 62( 23): 10497-10525 july.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1021/acs.jmedchem.9b00683

  • Artigo de periodico

    Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement (2019)

    Gomes, Juliana C; Cianni, Lorenzo ; Ribeiro, Jean; Rocho, Fernanda dos Reis ; Silva, Samelyn da Costa Martins ; Batista, Pedro Henrique J; Moraes, Carolina Borsoi ; Franco, Caio Haddad ; Freitas Junior, Lúcio H G ; Kenny, Peter W; Leitão, Andrei ; Burtoloso, Antonio Carlos Bender ; Vita, Daniela de; Montanari, Carlos Alberto

    Source: Bioorganic and Medicinal Chemistry. Unidades: IQSC, ICB

    Assunto: QUÍMICA

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      GOMES, Juliana C et al. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorganic and Medicinal Chemistry, v. 27, n. 22, p. x 115083, 2019Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2019.115083. Acesso em: 05 nov. 2024.

    • APA

      Gomes, J. C., Cianni, L., Ribeiro, J., Rocho, F. dos R., Silva, S. da C. M., Batista, P. H. J., et al. (2019). Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorganic and Medicinal Chemistry, 27( 22), x 115083. doi:10.1016/j.bmc.2019.115083

    • NLM

      Gomes JC, Cianni L, Ribeiro J, Rocho F dos R, Silva S da CM, Batista PHJ, Moraes CB, Franco CH, Freitas Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, Vita D de, Montanari CA. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement [Internet]. Bioorganic and Medicinal Chemistry. 2019 ; 27( 22): x 115083.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmc.2019.115083

    • Vancouver

      Gomes JC, Cianni L, Ribeiro J, Rocho F dos R, Silva S da CM, Batista PHJ, Moraes CB, Franco CH, Freitas Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, Vita D de, Montanari CA. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement [Internet]. Bioorganic and Medicinal Chemistry. 2019 ; 27( 22): x 115083.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmc.2019.115083

  • Artigo de periodico

    Predicting the affinity of halogenated reversible covalent inhibitors through relative binding free energy (2019)

    Lameira, Jerônimo ; Bonatto, Vinícius ; Cianni, Lorenzo ; Rocho, Fernanda dos Reis ; Leitão, Andrei ; Montanari, Carlos Alberto

    Source: Physical Chemistry Chemical Physics. Unidade: IQSC

    Subjects: QUÍMICA MÉDICA, CINÉTICA QUÍMICA, FÁRMACOS, NEOPLASIAS

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      LAMEIRA, Jerônimo et al. Predicting the affinity of halogenated reversible covalent inhibitors through relative binding free energy. Physical Chemistry Chemical Physics, v. 21, p. 24723-24730, 2019Tradução . . Disponível em: https://doi-org.ez67.periodicos.capes.gov.br/10.1039/C9CP04820K. Acesso em: 05 nov. 2024.

    • APA

      Lameira, J., Bonatto, V., Cianni, L., Rocho, F. dos R., Leitão, A., & Montanari, C. A. (2019). Predicting the affinity of halogenated reversible covalent inhibitors through relative binding free energy. Physical Chemistry Chemical Physics, 21, 24723-24730. doi:10.1039/c9cp04820k

    • NLM

      Lameira J, Bonatto V, Cianni L, Rocho F dos R, Leitão A, Montanari CA. Predicting the affinity of halogenated reversible covalent inhibitors through relative binding free energy [Internet]. Physical Chemistry Chemical Physics. 2019 ; 21 24723-24730.[citado 2024 nov. 05 ] Available from: https://doi-org.ez67.periodicos.capes.gov.br/10.1039/C9CP04820K

    • Vancouver

      Lameira J, Bonatto V, Cianni L, Rocho F dos R, Leitão A, Montanari CA. Predicting the affinity of halogenated reversible covalent inhibitors through relative binding free energy [Internet]. Physical Chemistry Chemical Physics. 2019 ; 21 24723-24730.[citado 2024 nov. 05 ] Available from: https://doi-org.ez67.periodicos.capes.gov.br/10.1039/C9CP04820K

  • Trabalho de evento-resumo

    How NEQUIMED/IQSC/USP’s using machine learning to aid drug discovery (2019)

    Montanari, Carlos Alberto ; Cianni, Lorenzo

    Source: Book of Abstracts. Conference titles: The São Carlos Special Medicinal Chemistry Meeting - SancaMedChem2019. Unidade: IQSC

    Subjects: QUÍMICA, INTELIGÊNCIA ARTIFICIAL, FÁRMACOS

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      MONTANARI, Carlos Alberto e CIANNI, Lorenzo. How NEQUIMED/IQSC/USP’s using machine learning to aid drug discovery. 2019, Anais.. São Paulo: Instituto de Química de São Carlos, IQSC, Universidade de São Paulo, USP, 2019. Disponível em: http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf. Acesso em: 05 nov. 2024.

    • APA

      Montanari, C. A., & Cianni, L. (2019). How NEQUIMED/IQSC/USP’s using machine learning to aid drug discovery. In Book of Abstracts. São Paulo: Instituto de Química de São Carlos, IQSC, Universidade de São Paulo, USP. Recuperado de http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf

    • NLM

      Montanari CA, Cianni L. How NEQUIMED/IQSC/USP’s using machine learning to aid drug discovery [Internet]. Book of Abstracts. 2019 ;[citado 2024 nov. 05 ] Available from: http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf

    • Vancouver

      Montanari CA, Cianni L. How NEQUIMED/IQSC/USP’s using machine learning to aid drug discovery [Internet]. Book of Abstracts. 2019 ;[citado 2024 nov. 05 ] Available from: http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf

  • Trabalho de evento-resumo

    Predicting the ΔΔGbind of halogenated reversible covalent inhibitors of hCatL through computer simulation (2019)

    Lameira, Jerônimo ; Bonatto, Vinícius ; Cianni, Lorenzo ; Rocho, Fernanda dos Reis ; Leitão, Andrei ; Montanari, Carlos Alberto

    Source: Book of Abstracts. Conference titles: The São Carlos Special Medicinal Chemistry Meeting - SancaMedChem2019. Unidade: IQSC

    Subjects: QUÍMICA MÉDICA, NEOPLASIAS

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    • ABNT

      LAMEIRA, Jerônimo et al. Predicting the ΔΔGbind of halogenated reversible covalent inhibitors of hCatL through computer simulation. 2019, Anais.. São Paulo: Instituto de Química de São Carlos, IQSC, Universidade de São Paulo, USP, 2019. Disponível em: http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf. Acesso em: 05 nov. 2024.

    • APA

      Lameira, J., Bonatto, V., Cianni, L., Rocho, F. dos R., Leitão, A., & Montanari, C. A. (2019). Predicting the ΔΔGbind of halogenated reversible covalent inhibitors of hCatL through computer simulation. In Book of Abstracts. São Paulo: Instituto de Química de São Carlos, IQSC, Universidade de São Paulo, USP. Recuperado de http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf

    • NLM

      Lameira J, Bonatto V, Cianni L, Rocho F dos R, Leitão A, Montanari CA. Predicting the ΔΔGbind of halogenated reversible covalent inhibitors of hCatL through computer simulation [Internet]. Book of Abstracts. 2019 ;[citado 2024 nov. 05 ] Available from: http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf

    • Vancouver

      Lameira J, Bonatto V, Cianni L, Rocho F dos R, Leitão A, Montanari CA. Predicting the ΔΔGbind of halogenated reversible covalent inhibitors of hCatL through computer simulation [Internet]. Book of Abstracts. 2019 ;[citado 2024 nov. 05 ] Available from: http://sancamedchem.iqsc.usp.br/files/2019/11/Book-of-abstracts-SancaMedChem2019.pdf

  • Artigo de periodico

    Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles (2018)

    Santos, Alberto Monteiro dos; Cianni, Lorenzo; De Vita, Daniela; Rosini, Fabiana; Leitão, Andrei ; Laughton, Charles A; Lameira, Jerônimo; Montanari, Carlos Alberto

    Source: Physical Chemistry Chemical Physics. Unidade: IQSC

    Subjects: DOENÇA DE CHAGAS, QUÍMICA MÉDICA

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      SANTOS, Alberto Monteiro dos et al. Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles. Physical Chemistry Chemical Physics, v. 20, n. 37, p. 24317-24328, 2018Tradução . . Disponível em: http://pubs-rsc-org.ez67.periodicos.capes.gov.br/en/content/articlepdf/2018/cp/c8cp03320j?page=search. Acesso em: 05 nov. 2024.

    • APA

      Santos, A. M. dos, Cianni, L., De Vita, D., Rosini, F., Leitão, A., Laughton, C. A., et al. (2018). Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles. Physical Chemistry Chemical Physics, 20( 37), 24317-24328. doi:10.1039/C8CP03320J

    • NLM

      Santos AM dos, Cianni L, De Vita D, Rosini F, Leitão A, Laughton CA, Lameira J, Montanari CA. Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles [Internet]. Physical Chemistry Chemical Physics. 2018 ;20( 37): 24317-24328.[citado 2024 nov. 05 ] Available from: http://pubs-rsc-org.ez67.periodicos.capes.gov.br/en/content/articlepdf/2018/cp/c8cp03320j?page=search

    • Vancouver

      Santos AM dos, Cianni L, De Vita D, Rosini F, Leitão A, Laughton CA, Lameira J, Montanari CA. Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles [Internet]. Physical Chemistry Chemical Physics. 2018 ;20( 37): 24317-24328.[citado 2024 nov. 05 ] Available from: http://pubs-rsc-org.ez67.periodicos.capes.gov.br/en/content/articlepdf/2018/cp/c8cp03320j?page=search

  • Artigo de periodico

    Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors (2018)

    Cianni, Lorenzo; Satori, Geraldo R; Rosini, Fabiana; De Vitta, Daniela; Pires, Gabriel Lino de Paula; Lopes, Bianca Rebelo; Leitão, Andrei ; Burtoloso, Antonio Carlos Bender ; Montanari, Carlos Alberto

    Source: Bioorganic Chemistry. Unidade: IQSC

    Subjects: MOLÉCULA, QUÍMICA MÉDICA

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      CIANNI, Lorenzo et al. Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors. Bioorganic Chemistry, p. 285-292, 2018Tradução . . Disponível em: https://doi.org/10.1016/j.bioorg.2018.04.006. Acesso em: 05 nov. 2024.

    • APA

      Cianni, L., Satori, G. R., Rosini, F., De Vitta, D., Pires, G. L. de P., Lopes, B. R., et al. (2018). Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors. Bioorganic Chemistry, 285-292. doi:10.1016/j.bioorg.2018.04.006

    • NLM

      Cianni L, Satori GR, Rosini F, De Vitta D, Pires GL de P, Lopes BR, Leitão A, Burtoloso ACB, Montanari CA. Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors [Internet]. Bioorganic Chemistry. 2018 ; 285-292.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bioorg.2018.04.006

    • Vancouver

      Cianni L, Satori GR, Rosini F, De Vitta D, Pires GL de P, Lopes BR, Leitão A, Burtoloso ACB, Montanari CA. Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors [Internet]. Bioorganic Chemistry. 2018 ; 285-292.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bioorg.2018.04.006

  • Trabalho de evento-resumo

    On the study of halogen bond interaction to increase cruzain affinity of covalently boundd reversible inhibitors (2017)

    Cianni, Lorenzo; Sartori, Geraldo; Vita, Daniela de; Rosini, Fabiana; Leitão, Andrei ; Montanari, Carlos Alberto

    Source: Proceedings. Conference titles: IUPAC General Assembly. Unidade: IQSC

    Assunto: HALOGÊNIOS

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      CIANNI, Lorenzo et al. On the study of halogen bond interaction to increase cruzain affinity of covalently boundd reversible inhibitors. 2017, Anais.. Durham: IUPAC, 2017. Disponível em: https://repositorio.usp.br/directbitstream/da742f21-6f52-4436-9709-ea8a58a5d735/P16976.pdf. Acesso em: 05 nov. 2024.

    • APA

      Cianni, L., Sartori, G., Vita, D. de, Rosini, F., Leitão, A., & Montanari, C. A. (2017). On the study of halogen bond interaction to increase cruzain affinity of covalently boundd reversible inhibitors. In Proceedings. Durham: IUPAC. Recuperado de https://repositorio.usp.br/directbitstream/da742f21-6f52-4436-9709-ea8a58a5d735/P16976.pdf

    • NLM

      Cianni L, Sartori G, Vita D de, Rosini F, Leitão A, Montanari CA. On the study of halogen bond interaction to increase cruzain affinity of covalently boundd reversible inhibitors [Internet]. Proceedings. 2017 ;[citado 2024 nov. 05 ] Available from: https://repositorio.usp.br/directbitstream/da742f21-6f52-4436-9709-ea8a58a5d735/P16976.pdf

    • Vancouver

      Cianni L, Sartori G, Vita D de, Rosini F, Leitão A, Montanari CA. On the study of halogen bond interaction to increase cruzain affinity of covalently boundd reversible inhibitors [Internet]. Proceedings. 2017 ;[citado 2024 nov. 05 ] Available from: https://repositorio.usp.br/directbitstream/da742f21-6f52-4436-9709-ea8a58a5d735/P16976.pdf

  • Trabalho de evento-resumo

    Planjemaneto, síntese e atividade tripanossomicida de inibidores covalentes reversíveis da enzima cruzaína (2017)

    Santos, Juliana Jarussi dos; De Vita, Daniela; Cianni, Lorenzo; Montanari, Carlos Alberto

    Source: Anais. Conference titles: Simpósio Internacional de Iniciação Científica e Tecnológica da USP - SIICUSP. Unidade: IQSC

    Assunto: DOENÇA DE CHAGAS

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    • ABNT

      SANTOS, Juliana Jarussi dos et al. Planjemaneto, síntese e atividade tripanossomicida de inibidores covalentes reversíveis da enzima cruzaína. 2017, Anais.. São Paulo: Instituto de Química de São Carlos, Universidade de São Paulo, 2017. Disponível em: http://siicusp.prp.usp.br/pt/programacao/. Acesso em: 05 nov. 2024.

    • APA

      Santos, J. J. dos, De Vita, D., Cianni, L., & Montanari, C. A. (2017). Planjemaneto, síntese e atividade tripanossomicida de inibidores covalentes reversíveis da enzima cruzaína. In Anais. São Paulo: Instituto de Química de São Carlos, Universidade de São Paulo. Recuperado de http://siicusp.prp.usp.br/pt/programacao/

    • NLM

      Santos JJ dos, De Vita D, Cianni L, Montanari CA. Planjemaneto, síntese e atividade tripanossomicida de inibidores covalentes reversíveis da enzima cruzaína [Internet]. Anais. 2017 ;[citado 2024 nov. 05 ] Available from: http://siicusp.prp.usp.br/pt/programacao/

    • Vancouver

      Santos JJ dos, De Vita D, Cianni L, Montanari CA. Planjemaneto, síntese e atividade tripanossomicida de inibidores covalentes reversíveis da enzima cruzaína [Internet]. Anais. 2017 ;[citado 2024 nov. 05 ] Available from: http://siicusp.prp.usp.br/pt/programacao/

  • Artigo de periodico

    A comparative study of warheads for design of cysteine protease inhibitors (2017)

    Silva, Daniel G da; Ribeiro, Jean Francisco Rosa; De Vita, Daniela; Cianni, Lorenzo; Franco, Caio Haddad; Freitas Junior, Lucio H; Moraes, Carolina Borsoi; Rocha, Josmar R; Burtoloso, Antonio Carlos Bender ; Kenny, Peter W; Leitão, Andrei ; Montanari, Carlos Alberto

    Source: Bioorganic & Medicinal Chemistry Letters. Unidade: IQSC

    Assunto: ALDEÍDOS

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      SILVA, Daniel G da et al. A comparative study of warheads for design of cysteine protease inhibitors. Bioorganic & Medicinal Chemistry Letters, v. 27, n. 22, p. 5031-5035, 2017Tradução . . Disponível em: https://doi.org/10.1016/j.bmcl.2017.10.002. Acesso em: 05 nov. 2024.

    • APA

      Silva, D. G. da, Ribeiro, J. F. R., De Vita, D., Cianni, L., Franco, C. H., Freitas Junior, L. H., et al. (2017). A comparative study of warheads for design of cysteine protease inhibitors. Bioorganic & Medicinal Chemistry Letters, 27( 22), 5031-5035. doi:10.1016/j.bmcl.2017.10.002

    • NLM

      Silva DG da, Ribeiro JFR, De Vita D, Cianni L, Franco CH, Freitas Junior LH, Moraes CB, Rocha JR, Burtoloso ACB, Kenny PW, Leitão A, Montanari CA. A comparative study of warheads for design of cysteine protease inhibitors [Internet]. Bioorganic & Medicinal Chemistry Letters. 2017 ; 27( 22): 5031-5035.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmcl.2017.10.002

    • Vancouver

      Silva DG da, Ribeiro JFR, De Vita D, Cianni L, Franco CH, Freitas Junior LH, Moraes CB, Rocha JR, Burtoloso ACB, Kenny PW, Leitão A, Montanari CA. A comparative study of warheads for design of cysteine protease inhibitors [Internet]. Bioorganic & Medicinal Chemistry Letters. 2017 ; 27( 22): 5031-5035.[citado 2024 nov. 05 ] Available from: https://doi.org/10.1016/j.bmcl.2017.10.002
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