Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L (2021)
- Authors:
- USP affiliated authors: LEITÃO, ANDREI - IQSC ; MONTANARI, CARLOS ALBERTO - IQSC ; CIANNI, LORENZO - IQSC ; ROCHO, FERNANDA DOS REIS - IQSC ; BONATTO, VINÍCIUS - IQSC ; MARTINS, FELIPE CARDOSO PRADO - IQSC ; SHAMIM, ANWAR - IQSC
- Unidade: IQSC
- DOI: 10.1016/j.bmc.2020.115827
- Subjects: QUÍMICA MÉDICA; NEOPLASIAS; INIBIDORES DE ENZIMAS
- Keywords: human cysteine proteases; cathepsin B; cathepsin L; nitrile inhibitors
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Bioorganic and Medicinal Chemistry
- ISSN: 0968-0896
- Volume/Número/Paginação/Ano: v. 29, p. 115827,
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
CIANNI, Lorenzo et al. Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L. Bioorganic and Medicinal Chemistry, v. 29, p. 115827, 2021Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2020.115827. Acesso em: 27 dez. 2025. -
APA
Cianni, L., Rocho, F. dos R., Bonatto, V., Martins, F. C. P., Lameira, J., Leitão, A., et al. (2021). Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L. Bioorganic and Medicinal Chemistry, 29, 115827. doi:10.1016/j.bmc.2020.115827 -
NLM
Cianni L, Rocho F dos R, Bonatto V, Martins FCP, Lameira J, Leitão A, Montanari CA, Shamim A. Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L [Internet]. Bioorganic and Medicinal Chemistry. 2021 ; 29 115827.[citado 2025 dez. 27 ] Available from: https://doi.org/10.1016/j.bmc.2020.115827 -
Vancouver
Cianni L, Rocho F dos R, Bonatto V, Martins FCP, Lameira J, Leitão A, Montanari CA, Shamim A. Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L [Internet]. Bioorganic and Medicinal Chemistry. 2021 ; 29 115827.[citado 2025 dez. 27 ] Available from: https://doi.org/10.1016/j.bmc.2020.115827 - Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations
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Informações sobre o DOI: 10.1016/j.bmc.2020.115827 (Fonte: oaDOI API)
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