Artigo de periodico

Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement (2019)

• Authors:
  • Gomes, Juliana C
  • Cianni, Lorenzo
  • Ribeiro, Jean
  • Rocho, Fernanda dos Reis
  • Silva, Samelyn da Costa Martins
  • Batista, Pedro Henrique J
  • Moraes, Carolina Borsoi
  • Franco, Caio Haddad
  • Freitas Junior, Lúcio H G
  • Kenny, Peter W
  • Leitão, Andrei
  • Burtoloso, Antonio Carlos Bender
  • Vita, Daniela de
  • Montanari, Carlos Alberto
• USP affiliated authors: LEITÃO, ANDREI - IQSC ; BURTOLOSO, ANTONIO CARLOS BENDER - IQSC ; MONTANARI, CARLOS ALBERTO - IQSC ; GOMES, JULIANA CRISTINA - IQSC ; CIANNI, LORENZO - IQSC ; RIBEIRO, JEAN FRANCISCO ROSA - IQSC ; ROCHO, FERNANDA DOS REIS - IQSC ; SILVA, SAMELYN DA COSTA MARTINS - IQSC ; BATISTA, PEDRO HENRIQUE JATAI - IQSC ; FRANCO, CAIO HADDAD - ICB ; VITA, DANIELA DE - IQSC
• Unidades: IQSC; ICB
• DOI: 10.1016/j.bmc.2019.115083
• Assunto: QUÍMICA
• Keywords: Covalent inhibitor; Cruzain; Covalent inhibitorCruzainCysteine proteaseGroup efficiencyLipophilic efficiencyNon-additivityStructure-activity relationship; Cysteine protease
• Agências de fomento:
  • Financiado pelo CNPq
  • Financiado pela FAPESP
• Language: Inglês
• Imprenta:
  • Publisher place: Oxford
  • Date published: 2019
• Source:
  • Título: Bioorganic and Medicinal Chemistry
  • ISSN: 0968-0896
  • Volume/Número/Paginação/Ano: v. 27, n. 22, p.x 115083, nov, 2019


Informações sobre a disponibilidade de versões do artigo em acesso aberto coletadas automaticamente via oaDOI API (Unpaywall).

Status:

Artigo possui versão em acesso aberto em repositório (Green Open Access)

Acessar versão aberta:

• URL de acesso aberto
• PDF de acesso aberto

Por se tratar de integração com serviço externo, podem existir diferentes versões do trabalho (como preprints ou postprints), que podem diferir da versão publicada.

---

Download do texto completo

Tipo	Nome	Link
	P18260.pdf

How to cite

A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

• ABNT

  GOMES, Juliana C et al. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorganic and Medicinal Chemistry, v. 27, n. 22, p. x 115083, 2019Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2019.115083. Acesso em: 01 abr. 2026.

• APA

  Gomes, J. C., Cianni, L., Ribeiro, J., Rocho, F. dos R., Silva, S. da C. M., Batista, P. H. J., et al. (2019). Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorganic and Medicinal Chemistry, 27( 22), x 115083. doi:10.1016/j.bmc.2019.115083

• NLM

  Gomes JC, Cianni L, Ribeiro J, Rocho F dos R, Silva S da CM, Batista PHJ, Moraes CB, Franco CH, Freitas Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, Vita D de, Montanari CA. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement [Internet]. Bioorganic and Medicinal Chemistry. 2019 ; 27( 22): x 115083.[citado 2026 abr. 01 ] Available from: https://doi.org/10.1016/j.bmc.2019.115083

• Vancouver

  Gomes JC, Cianni L, Ribeiro J, Rocho F dos R, Silva S da CM, Batista PHJ, Moraes CB, Franco CH, Freitas Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, Vita D de, Montanari CA. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement [Internet]. Bioorganic and Medicinal Chemistry. 2019 ; 27( 22): x 115083.[citado 2026 abr. 01 ] Available from: https://doi.org/10.1016/j.bmc.2019.115083

Últimas obras dos mesmos autores vinculados com a USP cadastradas na BDPI:

• N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization
• Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism
• Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB
• Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor
• Fat or flat?: The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules
• Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?
• The Effect of Dipeptidyl Nitrile Derivatives on Pancreatic Ductal Adenocarcinoma Cells In Vitro
• Predicting the affinity of halogenated reversible covalent inhibitors through relative binding free energy
• Predicting the ΔΔGbind of halogenated reversible covalent inhibitors of hCatL through computer simulation
• On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors