The immunosuppressive activity of myeloid-derived suppressor cells in murine Paracoccidioidomycosis relies on Indoleamine 2,3-dioxygenase activity and Dectin-1 and TLRs signaling (2023)
- Authors:
- Autor USP: CALICH, VERA LUCIA GARCIA - ICB
- Unidade: ICB
- DOI: 10.1038/s41598-023-39262-8
- Subjects: CAMUNDONGOS; FÁRMACOS IMUNOSSUPRESSORES; PARACOCCIDIOIDOMICOSE; SEROTONINA; RECEPTORES DE SEROTONINA; CÉLULAS SANGUÍNEAS; PROLIFERAÇÃO CELULAR; DOENÇAS AUTOIMUNES; ATIVAÇÃO ENZIMÁTICA
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher: Nature Publishing Group
- Publisher place: London
- Date published: 2023
- Source:
- Título: Scientific Reports
- ISSN: 2045-2322
- Volume/Número/Paginação/Ano: v. 13, n. 1, p. 1-15, art. 12391, 2023
- Status:
- Artigo publicado em periódico de acesso aberto (Gold Open Access)
- Versão do Documento:
- Versão publicada (Published version)
- Acessar versão aberta:
-
ABNT
KAMINSK, Valéria de Lima et al. The immunosuppressive activity of myeloid-derived suppressor cells in murine Paracoccidioidomycosis relies on Indoleamine 2,3-dioxygenase activity and Dectin-1 and TLRs signaling. Scientific Reports, v. 13, n. 1, p. 1-15, 2023Tradução . . Disponível em: https://doi.org/10.1038/s41598-023-39262-8. Acesso em: 31 mar. 2026. -
APA
Kaminsk, V. de L., Preite, N. W., Borges, B. M., Santos, B. V. dos, Loures, F. V., & Calich, V. L. G. (2023). The immunosuppressive activity of myeloid-derived suppressor cells in murine Paracoccidioidomycosis relies on Indoleamine 2,3-dioxygenase activity and Dectin-1 and TLRs signaling. Scientific Reports, 13( 1), 1-15. doi:10.1038/s41598-023-39262-8 -
NLM
Kaminsk V de L, Preite NW, Borges BM, Santos BV dos, Loures FV, Calich VLG. The immunosuppressive activity of myeloid-derived suppressor cells in murine Paracoccidioidomycosis relies on Indoleamine 2,3-dioxygenase activity and Dectin-1 and TLRs signaling [Internet]. Scientific Reports. 2023 ; 13( 1): 1-15.[citado 2026 mar. 31 ] Available from: https://doi.org/10.1038/s41598-023-39262-8 -
Vancouver
Kaminsk V de L, Preite NW, Borges BM, Santos BV dos, Loures FV, Calich VLG. The immunosuppressive activity of myeloid-derived suppressor cells in murine Paracoccidioidomycosis relies on Indoleamine 2,3-dioxygenase activity and Dectin-1 and TLRs signaling [Internet]. Scientific Reports. 2023 ; 13( 1): 1-15.[citado 2026 mar. 31 ] Available from: https://doi.org/10.1038/s41598-023-39262-8 - cd28 costimulatory molecule deficiency in more severe paracoccidioides brasiliensis infection but protects mice from life-threatening immunopathology
- Paracoccidioides brasiliensis infection determines dentric cells to diferentiate to the plasmacytoid subpopulation which induces a more severe pulmonary infection when transfered to resistant mice
- The IDO-AhR axis controls Th17/Treg immunity in a pulmonary model of fungal infection
- TLR-2 is a negative regulator of TH17 cells and tissue pathology in a pulmonary model of fungal infection
- Absence of TLR2 results in less severe paracoccidioidomycosis but increased inflammatory response caused by PMN & TH17 cells
- Toll like receptors and the adaptor molecule MYD88 play an important role in pulmonary paracoccidioidomycosis
- TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection
- Human alfa / beta and gama / delta t cells respond to proteins of the yeast form of paracoccidioides brasiliensis
- The immune response of high (H) and low responders (L) mice (selection III) and F1 (HIII x LIII) hybrids to paracoccidioides brasiliensis infection
- PMN leukocytes play a more prominent role in natural immunity of susceptible than resistant mice to pulmonary paracoccidiodomycosis
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