Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet (2022)
- Authors:
- Autor USP: FIGUEIRA, TIAGO REZENDE - EEFERP
- Unidade: EEFERP
- DOI: 10.1016/j.ejphar.2022.174750
- Subjects: FÍGADO GORDUROSO; MUTAÇÃO; GORDURAS NA DIETA
- Keywords: Liver steatosis; Non-alcoholic steatohepatitis (NASH); Pyruvate dehydrogenase kinase (PDK); Nnt mutation; C57BL/6J mouse
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: European Journal of Pharmacology
- ISSN: 0014-2999
- Volume/Número/Paginação/Ano: v. 917, art. 174750, p. 1-10, 2022
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
NAVARRO, Claudia D. C. et al. Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet. European Journal of Pharmacology, v. 917, p. 1-10, 2022Tradução . . Disponível em: https://doi.org/10.1016/j.ejphar.2022.174750. Acesso em: 15 mar. 2025. -
APA
Navarro, C. D. C., Francisco, A., Figueira, T. R., Ronchi, J. A., Oliveira, H. C. F. de, Vercesi, A. E., & Castilho, R. F. (2022). Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet. European Journal of Pharmacology, 917, 1-10. doi:10.1016/j.ejphar.2022.174750 -
NLM
Navarro CDC, Francisco A, Figueira TR, Ronchi JA, Oliveira HCF de, Vercesi AE, Castilho RF. Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet [Internet]. European Journal of Pharmacology. 2022 ; 917 1-10.[citado 2025 mar. 15 ] Available from: https://doi.org/10.1016/j.ejphar.2022.174750 -
Vancouver
Navarro CDC, Francisco A, Figueira TR, Ronchi JA, Oliveira HCF de, Vercesi AE, Castilho RF. Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet [Internet]. European Journal of Pharmacology. 2022 ; 917 1-10.[citado 2025 mar. 15 ] Available from: https://doi.org/10.1016/j.ejphar.2022.174750 - Insights on how mitochondrial NAD(P)+ transhydrogenase plays a central metabolic role in proinflammatory macrophages. [Carta]
- NADPH supply and the contribution of NAD(P)+ transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria
- Facilitation of Ca2+-induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment
- Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high‐fat diet
- Mitochondrial NAD(P)+ transhydrogenase is unevenly distributed in different brain regions, and its loss causes depressive-like behavior and motor dysfunction in mice
- Can NAD(P)+ transhydrogenase (NNT) mediate a physiologically meaningful increase in energy expenditure by mitochondria during H2O2 removal? [Carta]
- Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition
Informações sobre o DOI: 10.1016/j.ejphar.2022.174750 (Fonte: oaDOI API)
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