Indoles hit-to-lead for chagas disease: lessons learned within the LOLA consortium (2022)
- Authors:
- Cruz, Luiza
- Silva, Adriana Corrêa da
- Feltrin, Clarissa
- Dichiara, Maria
- Ferrins, Lori
- Moraes, Carolina Borsoi
- Sjo, Peter
- Andricopulo, Adriano Defini
- Mowbray, Charles
- Oliveira, Ramon Guerra de
- Dessoy, Marco Aurélio
- Santos, Deborah Araújo dos
- Oliveira, Luiz Fernando Nascimento de
- Mollo, María Cruz
- Lee, Eun
- Duarte, Simone Michelan
- Andricopulo, Renata Krogh
- Chelucci, Rafael Consolin
- Ferreira, Leonardo Luiz Gomes
- Kratz, Jadel Muller
- Dias, Luiz Carlos
- USP affiliated authors: ANDRICOPULO, ADRIANO DEFINI - IFSC ; DUARTE, SIMONE MICHELAN - IFSC ; ANDRICOPULO, RENATA KROGH - IFSC ; CHELUCCI, RAFAEL CONSOLIN - IFSC ; FERREIRA, LEONARDO LUIZ GOMES - IFSC
- Unidade: IFSC
- Subjects: DOENÇAS NEGLIGENCIADAS; DOENÇA DE CHAGAS
- Keywords: Phenotypic screening; Drug Discovery; Medicinal Chemistry; Indoles; CYP51 inhibition
- Language: Inglês
- Imprenta:
- Source:
- Título: Anais eletrônicos
- Conference titles: Brazilian Symposium on Medicinal Chemistry - BrazMedChem
-
ABNT
CRUZ, Luiza et al. Indoles hit-to-lead for chagas disease: lessons learned within the LOLA consortium. 2022, Anais.. Campinas: Galoá, 2022. Disponível em: https://proceedings.science/brazmedchem-2022/papers/indoles-hit-to-lead-for-chagas-disease---lessons-learned-within-the-lola-consortium. Acesso em: 10 fev. 2026. -
APA
Cruz, L., Silva, A. C. da, Feltrin, C., Dichiara, M., Ferrins, L., Moraes, C. B., et al. (2022). Indoles hit-to-lead for chagas disease: lessons learned within the LOLA consortium. In Anais eletrônicos. Campinas: Galoá. Recuperado de https://proceedings.science/brazmedchem-2022/papers/indoles-hit-to-lead-for-chagas-disease---lessons-learned-within-the-lola-consortium. -
NLM
Cruz L, Silva AC da, Feltrin C, Dichiara M, Ferrins L, Moraes CB, Sjo P, Andricopulo AD, Mowbray C, Oliveira RG de, Dessoy MA, Santos DA dos, Oliveira LFN de, Mollo MC, Lee E, Duarte SM, Andricopulo RK, Chelucci RC, Ferreira LLG, Kratz JM, Dias LC. Indoles hit-to-lead for chagas disease: lessons learned within the LOLA consortium [Internet]. Anais eletrônicos. 2022 ;[citado 2026 fev. 10 ] Available from: https://proceedings.science/brazmedchem-2022/papers/indoles-hit-to-lead-for-chagas-disease---lessons-learned-within-the-lola-consortium. -
Vancouver
Cruz L, Silva AC da, Feltrin C, Dichiara M, Ferrins L, Moraes CB, Sjo P, Andricopulo AD, Mowbray C, Oliveira RG de, Dessoy MA, Santos DA dos, Oliveira LFN de, Mollo MC, Lee E, Duarte SM, Andricopulo RK, Chelucci RC, Ferreira LLG, Kratz JM, Dias LC. Indoles hit-to-lead for chagas disease: lessons learned within the LOLA consortium [Internet]. Anais eletrônicos. 2022 ;[citado 2026 fev. 10 ] Available from: https://proceedings.science/brazmedchem-2022/papers/indoles-hit-to-lead-for-chagas-disease---lessons-learned-within-the-lola-consortium. - Convergent synthesis of proline-functionalized pyrazolopyrimidines as anti-T. cruzi bioactive compounds
- Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease
- Discovery of arylpiperazines with broad-spectrum antimicrobial activity and favorable pharmacokinetic profiles
- Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum
- Novel deferasirox analogues designed as iron chelating agents for iron overload treatment
- Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents
- Antitrypanosomal aminobenzimidazoles: hit to lead expansion of new chemical entities against Trypanosoma cruzi and Leishmania infantum
- Antitrypanosomal Benzoxazinone series: hit-to-lead campaign and multiparametric optimization
- SAR studies on a series of reversible competitive inhibitors of cruzain from Trypanosoma cruzi
- Structure-activity relationships of novel N-imidazoylpiperazines with potent anti-trypanosoma cruzi activity
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