Antitrypanosomal Benzoxazinone series: hit-to-lead campaign and multiparametric optimization (2022)
- Authors:
- Mollo, María Cruz
- Cruz, Luiza
- Dessoy, Marco Aurélio
- Lee, Eun
- Oliveira, Ramon Guerra de
- Dutra, Francielle
- Duarte, Simone Michelan
- Andricopulo, Renata Krogh
- Ferreira, Leonardo Luiz Gomes
- Chelucci, Rafael Consolin
- Feltrin, Clarissa
- Moraes, Carolina Borsoi
- Andricopulo, Adriano Defini
- Kratz, Jadel
- Sjö, Peter
- Mowbray, Charles
- Dias, Luiz Carlos
- USP affiliated authors: ANDRICOPULO, ADRIANO DEFINI - IFSC ; ANDRICOPULO, RENATA KROGH - IFSC ; DUARTE, SIMONE MICHELAN - IFSC ; FERREIRA, LEONARDO LUIZ GOMES - IFSC ; CHELUCCI, RAFAEL CONSOLIN - IFSC ; FELTRIN, CLARISSA - ICB
- Unidades: IFSC; ICB
- Subjects: TRYPANOSOMA CRUZI; PLANEJAMENTO DE FÁRMACOS
- Keywords: Chagas disease; Benzoxazinones; Drug Discovery; SAR; Phenotypic screening
- Language: Inglês
- Imprenta:
- Source:
- Título: Anais eletrônicos
- Conference titles: Brazilian Symposium on Medicinal Chemistry - BrazMedChem
-
ABNT
MOLLO, María Cruz et al. Antitrypanosomal Benzoxazinone series: hit-to-lead campaign and multiparametric optimization. 2022, Anais.. Campinas: Galoá, 2022. Disponível em: https://proceedings.science/brazmedchem-2022/papers/antitrypanosomal-benzoxazinone-series--hit-to-lead-campaign-and-multiparametric-optimization-. Acesso em: 10 fev. 2026. -
APA
Mollo, M. C., Cruz, L., Dessoy, M. A., Lee, E., Oliveira, R. G. de, Dutra, F., et al. (2022). Antitrypanosomal Benzoxazinone series: hit-to-lead campaign and multiparametric optimization. In Anais eletrônicos. Campinas: Galoá. Recuperado de https://proceedings.science/brazmedchem-2022/papers/antitrypanosomal-benzoxazinone-series--hit-to-lead-campaign-and-multiparametric-optimization-. -
NLM
Mollo MC, Cruz L, Dessoy MA, Lee E, Oliveira RG de, Dutra F, Duarte SM, Andricopulo RK, Ferreira LLG, Chelucci RC, Feltrin C, Moraes CB, Andricopulo AD, Kratz J, Sjö P, Mowbray C, Dias LC. Antitrypanosomal Benzoxazinone series: hit-to-lead campaign and multiparametric optimization [Internet]. Anais eletrônicos. 2022 ;[citado 2026 fev. 10 ] Available from: https://proceedings.science/brazmedchem-2022/papers/antitrypanosomal-benzoxazinone-series--hit-to-lead-campaign-and-multiparametric-optimization-. -
Vancouver
Mollo MC, Cruz L, Dessoy MA, Lee E, Oliveira RG de, Dutra F, Duarte SM, Andricopulo RK, Ferreira LLG, Chelucci RC, Feltrin C, Moraes CB, Andricopulo AD, Kratz J, Sjö P, Mowbray C, Dias LC. Antitrypanosomal Benzoxazinone series: hit-to-lead campaign and multiparametric optimization [Internet]. Anais eletrônicos. 2022 ;[citado 2026 fev. 10 ] Available from: https://proceedings.science/brazmedchem-2022/papers/antitrypanosomal-benzoxazinone-series--hit-to-lead-campaign-and-multiparametric-optimization-. - Indoles hit-to-lead for chagas disease: lessons learned within the LOLA consortium
- Convergent synthesis of proline-functionalized pyrazolopyrimidines as anti-T. cruzi bioactive compounds
- Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease
- Discovery of arylpiperazines with broad-spectrum antimicrobial activity and favorable pharmacokinetic profiles
- Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum
- Novel deferasirox analogues designed as iron chelating agents for iron overload treatment
- Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents
- Antitrypanosomal aminobenzimidazoles: hit to lead expansion of new chemical entities against Trypanosoma cruzi and Leishmania infantum
- SAR studies on a series of reversible competitive inhibitors of cruzain from Trypanosoma cruzi
- Structure-activity relationships of novel N-imidazoylpiperazines with potent anti-trypanosoma cruzi activity
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