Optimized HDAC inhibitors induce robust γ-globin gene expression and exhibit superior efficacy to hydroxyurea in Sickle Cell Disease models (2025)
- Authors:
- USP affiliated authors: FERREIRA, LEONARDO LUIZ GOMES - IFSC ; DUARTE, SIMONE MICHELAN - IFSC ; ANDRICOPULO, ADRIANO DEFINI - IFSC ; CHELUCCI, RAFAEL CONSOLIN - IFSC
- Unidade: IFSC
- Subjects: DOENÇA DE CHAGAS; PLANEJAMENTO DE FÁRMACOS
- Keywords: Chagas disease; Sickle cell disease; Histone deacetylase; Fetal hemoglobin inducers
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher: Universidade Federal do Rio de Janeiro - UFRJ
- Publisher place: Rio de Janeiro
- Date published: 2025
- Source:
- Título: Annals
- Conference titles: Brazilian Symposium on Medicinal Chemistry - BrazMedChem
-
ABNT
PAVAN, Aline Renata et al. Optimized HDAC inhibitors induce robust γ-globin gene expression and exhibit superior efficacy to hydroxyurea in Sickle Cell Disease models. 2025, Anais.. Rio de Janeiro: Universidade Federal do Rio de Janeiro - UFRJ, 2025. . Acesso em: 15 fev. 2026. -
APA
Pavan, A. R., Pastre, V. G. de F., Lanaro, C., Albuquerque, D. M. de, Chelucci, R. C., Duarte, S. M., et al. (2025). Optimized HDAC inhibitors induce robust γ-globin gene expression and exhibit superior efficacy to hydroxyurea in Sickle Cell Disease models. In Annals. Rio de Janeiro: Universidade Federal do Rio de Janeiro - UFRJ. -
NLM
Pavan AR, Pastre VG de F, Lanaro C, Albuquerque DM de, Chelucci RC, Duarte SM, Ferreira LLG, Andricopulo AD, Costa FF, Santos JL dos. Optimized HDAC inhibitors induce robust γ-globin gene expression and exhibit superior efficacy to hydroxyurea in Sickle Cell Disease models. Annals. 2025 ;[citado 2026 fev. 15 ] -
Vancouver
Pavan AR, Pastre VG de F, Lanaro C, Albuquerque DM de, Chelucci RC, Duarte SM, Ferreira LLG, Andricopulo AD, Costa FF, Santos JL dos. Optimized HDAC inhibitors induce robust γ-globin gene expression and exhibit superior efficacy to hydroxyurea in Sickle Cell Disease models. Annals. 2025 ;[citado 2026 fev. 15 ] - Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease
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