Synthesis and Self-Assembly of Poly(N-Vinylcaprolactam)-b-Poly(ε-Caprolactone) Block Copolymers via the Combination of RAFT/MADIX and Ring-Opening Polymerizations (2020)
- Authors:
- USP affiliated authors: SAMPAIO, SIMONE DE FÁTIMA MEDEIROS - EEL ; SANTOS, AMILTON MARTINS DOS - EEL ; CARVALHO, LAYDE TEIXEIRA DE - EEL ; MORAES, RODOLFO PACHECO DE - FM
- Unidades: EEL; FM
- DOI: 10.3390/polym12061252
- Subjects: POLÍMEROS (MATERIAIS); POLIMERIZAÇÃO
- Keywords: thermosensitive; amphiphilic; block copolymers; poly(N-vinylcaprolactam); ROP; RAFT/MADIX polymerization
- Agências de fomento:
- Language: Inglês
- Abstract: Well-defined amphiphilic, biocompatible and partially biodegradable, thermo-responsive poly(N-vinylcaprolactam)-b-poly(ε-caprolactone) (PNVCL-b-PCL) block copolymers were synthesized by combining reversible addition-fragmentation chain transfer (RAFT) and ring-opening polymerizations (ROP). Poly(N-vinylcaprolactam) containing xanthate and hydroxyl end groups (X–PNVCL–OH) was first synthesized by RAFT/macromolecular design by the interchange of xanthates (RAFT/MADIX) polymerization of NVCL mediated by a chain transfer agent containing a hydroxyl function. The xanthate-end group was then removed from PNVCL by a radical-induced process. Finally, the hydroxyl end-capped PNVCL homopolymer was used as a macroinitiator in the ROP of ε-caprolactone (ε-CL) to obtain PNVCL-b-PCL block copolymers. These (co)polymers were characterized by Size Exclusion Chromatography (SEC), Fourier-Transform Infrared spectroscopy (FTIR), Proton Nuclear Magnetic Resonance spectroscopy (1H NMR), UV–vis and Differential Scanning Calorimetry (DSC) measurements. The critical micelle concentration (CMC) of the block copolymers in aqueous solution measured by the fluorescence probe technique decreased with increasing the length of the hydrophobic block. However, dynamic light scattering (DLS) demonstrated that the size of the micelles increased with increasing the proportion of hydrophobic segments. The morphology observed by cryo-TEM demonstrated that the micelles have a pointed-oval-shape. UV–vis and DLS analyses showed that these block copolymers have a temperature-responsive behavior with a lower critical solution temperature (LCST) that could be tuned by varying the block copolymer composition.
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ABNT
MORAES, Rodolfo Minto de et al. Synthesis and Self-Assembly of Poly(N-Vinylcaprolactam)-b-Poly(ε-Caprolactone) Block Copolymers via the Combination of RAFT/MADIX and Ring-Opening Polymerizations. Polymers, v. 12, n. 1252, 2020Tradução . . Disponível em: https://doi.org/10.3390/polym12061252. Acesso em: 05 ago. 2025. -
APA
Moraes, R. M. de, Carvalho, L. T., Alves, G. M., Medeiros, S. de F., Bourgeat-Lami, E., & Santos, A. M. dos. (2020). Synthesis and Self-Assembly of Poly(N-Vinylcaprolactam)-b-Poly(ε-Caprolactone) Block Copolymers via the Combination of RAFT/MADIX and Ring-Opening Polymerizations. Polymers, 12( 1252). doi:10.3390/polym12061252 -
NLM
Moraes RM de, Carvalho LT, Alves GM, Medeiros S de F, Bourgeat-Lami E, Santos AM dos. Synthesis and Self-Assembly of Poly(N-Vinylcaprolactam)-b-Poly(ε-Caprolactone) Block Copolymers via the Combination of RAFT/MADIX and Ring-Opening Polymerizations [Internet]. Polymers. 2020 ;12( 1252):[citado 2025 ago. 05 ] Available from: https://doi.org/10.3390/polym12061252 -
Vancouver
Moraes RM de, Carvalho LT, Alves GM, Medeiros S de F, Bourgeat-Lami E, Santos AM dos. Synthesis and Self-Assembly of Poly(N-Vinylcaprolactam)-b-Poly(ε-Caprolactone) Block Copolymers via the Combination of RAFT/MADIX and Ring-Opening Polymerizations [Internet]. Polymers. 2020 ;12( 1252):[citado 2025 ago. 05 ] Available from: https://doi.org/10.3390/polym12061252 - Synthesis and Self-Assembly of Poly(N-Vinylcaprolactam)-b-Poly(ε-Caprolactone) Block Copolymers via the Combination of RAFT/MADIX and Ring-Opening Polymerizations
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Informações sobre o DOI: 10.3390/polym12061252 (Fonte: oaDOI API)
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