Artigo de periodico

Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs (2022)

• Authors:
  • Sta, Marwa
  • Tada, Dayane Batista
  • Medeiros, Simone de Fátima
  • Santos, Amilton Martins dos
  • Demarquette, Nicole Raymonde
• USP affiliated authors: SAMPAIO, SIMONE DE FÁTIMA MEDEIROS - EEL ; SANTOS, AMILTON MARTINS DOS - EEL
• Unidade: EEL
• DOI: 10.1016/j.mseb.2021.115531
• Assunto: TERMOANÁLISE
• Keywords: Drug delivery; pH-sensitive; Themo-sensitive; Electrospinning; Fibers; Controlled release
• Agências de fomento:
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Financiamento NSERC
• Language: Inglês
• Abstract: In this study, poly(N-vinylcaprolactam-co-acrylic acid) (poly(NVCL-co-AA)) containing 20 and 30 mol% AA, were used to prepare thermo-and-pH-sensitive fibers containing a hydrophobic drug, ketoprofen, via electrospinning. Ketoprofen entrapment efficiency was assessed via UV–visible spectroscopy and revealed high values. The interaction drug/copolymer was investigated by FTIR, which indicated the drug entrapment into the fibers. The crystallinity of the ketoprofen-loaded fibers evaluated via DSC confirmed the presence of ketoprofen in its amorphous phase. Cytotoxicity of ketoprofen-loaded fibers was evaluated by cell viability assays using MTT. The results showed that the copolymer was not cytotoxic at a low ketoprofen concentration. The ketoprofen release profile was analyzed using independent and model-dependent approaches and showed slow-release rates at high temperatures. The study of the drug release mechanism showed that the Korsmeyer–Peppas model fits to the release behavior. These findings may expand poly(NVCL-co-AA) application making them promising candidates for temperature and pH responsive drug delivery systems.
• Imprenta:
  • Publisher: Elsevier
  • Date published: 2022
• Source:
  • Título: Materials Science and Engineering B-Advanced Functional Solid-State Materials
  • ISSN: 09215107
  • Volume/Número/Paginação/Ano: v.276, p.115531-, 2022

Informações sobre o DOI: 10.1016/j.mseb.2021.115531 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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• ABNT

  STA, Marwa et al. Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs. Materials Science and Engineering B-Advanced Functional Solid-State Materials, v. 276, p. 115531-, 2022Tradução . . Disponível em: https://doi.org/10.1016/j.mseb.2021.115531. Acesso em: 29 dez. 2025.

• APA

  Sta, M., Tada, D. B., Medeiros, S. de F., Santos, A. M. dos, & Demarquette, N. R. (2022). Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs. Materials Science and Engineering B-Advanced Functional Solid-State Materials, 276, 115531-. doi:10.1016/j.mseb.2021.115531

• NLM

  Sta M, Tada DB, Medeiros S de F, Santos AM dos, Demarquette NR. Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs [Internet]. Materials Science and Engineering B-Advanced Functional Solid-State Materials. 2022 ;276 115531-.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1016/j.mseb.2021.115531

• Vancouver

  Sta M, Tada DB, Medeiros S de F, Santos AM dos, Demarquette NR. Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs [Internet]. Materials Science and Engineering B-Advanced Functional Solid-State Materials. 2022 ;276 115531-.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1016/j.mseb.2021.115531

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