Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs (2022)
- Authors:
- USP affiliated authors: SAMPAIO, SIMONE DE FÁTIMA MEDEIROS - EEL ; SANTOS, AMILTON MARTINS DOS - EEL
- Unidade: EEL
- DOI: 10.1016/j.mseb.2021.115531
- Assunto: TERMOANÁLISE
- Keywords: Drug delivery; pH-sensitive; Themo-sensitive; Electrospinning; Fibers; Controlled release
- Agências de fomento:
- Language: Inglês
- Abstract: In this study, poly(N-vinylcaprolactam-co-acrylic acid) (poly(NVCL-co-AA)) containing 20 and 30 mol% AA, were used to prepare thermo-and-pH-sensitive fibers containing a hydrophobic drug, ketoprofen, via electrospinning. Ketoprofen entrapment efficiency was assessed via UV–visible spectroscopy and revealed high values. The interaction drug/copolymer was investigated by FTIR, which indicated the drug entrapment into the fibers. The crystallinity of the ketoprofen-loaded fibers evaluated via DSC confirmed the presence of ketoprofen in its amorphous phase. Cytotoxicity of ketoprofen-loaded fibers was evaluated by cell viability assays using MTT. The results showed that the copolymer was not cytotoxic at a low ketoprofen concentration. The ketoprofen release profile was analyzed using independent and model-dependent approaches and showed slow-release rates at high temperatures. The study of the drug release mechanism showed that the Korsmeyer–Peppas model fits to the release behavior. These findings may expand poly(NVCL-co-AA) application making them promising candidates for temperature and pH responsive drug delivery systems.
- Imprenta:
- Source:
- Título: Materials Science and Engineering B-Advanced Functional Solid-State Materials
- ISSN: 09215107
- Volume/Número/Paginação/Ano: v.276, p.115531-, 2022
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
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ABNT
STA, Marwa et al. Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs. Materials Science and Engineering B-Advanced Functional Solid-State Materials, v. 276, p. 115531-, 2022Tradução . . Disponível em: https://doi.org/10.1016/j.mseb.2021.115531. Acesso em: 02 out. 2024. -
APA
Sta, M., Tada, D. B., Medeiros, S. de F., Santos, A. M. dos, & Demarquette, N. R. (2022). Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs. Materials Science and Engineering B-Advanced Functional Solid-State Materials, 276, 115531-. doi:10.1016/j.mseb.2021.115531 -
NLM
Sta M, Tada DB, Medeiros S de F, Santos AM dos, Demarquette NR. Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs [Internet]. Materials Science and Engineering B-Advanced Functional Solid-State Materials. 2022 ;276 115531-.[citado 2024 out. 02 ] Available from: https://doi.org/10.1016/j.mseb.2021.115531 -
Vancouver
Sta M, Tada DB, Medeiros S de F, Santos AM dos, Demarquette NR. Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs [Internet]. Materials Science and Engineering B-Advanced Functional Solid-State Materials. 2022 ;276 115531-.[citado 2024 out. 02 ] Available from: https://doi.org/10.1016/j.mseb.2021.115531 - Biocompatible and multi-responsive poly(N-vinylcaprolactam)-based microgels: the role of acidic comonomers in the colloidal properties and phase transition as a function of temperature an pH
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Informações sobre o DOI: 10.1016/j.mseb.2021.115531 (Fonte: oaDOI API)
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