Investigation of novel antitrypanosomal compounds through experimental and in silico medicinal chemistry approaches (2025)
- Authors:
- USP affiliated authors: DUARTE, SIMONE MICHELAN - IFSC ; FERREIRA, LEONARDO LUIZ GOMES - IFSC ; ANDRICOPULO, ADRIANO DEFINI - IFSC ; AFONSO, MAYNARA - IFSC ; COSTA, ANALU ROCHA - IFSC ; SILVA, JOÃO VICTOR DA SILVA E - IFSC ; CHELUCCI, RAFAEL CONSOLIN - IFSC ; DÖRING, THIAGO HENRIQUE - IFSC
- Unidade: IFSC
- Subjects: DOENÇA DE CHAGAS; PLANEJAMENTO DE FÁRMACOS
- Keywords: NTDs; Chagas disease; Drug discovery
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher: Universidade Federal do Rio de Janeiro - UFRJ
- Publisher place: Rio de Janeiro
- Date published: 2025
- Source:
- Título: Annals
- Conference titles: Brazilian Symposium on Medicinal Chemistry - BrazMedChem
-
ABNT
AFONSO, Maynara et al. Investigation of novel antitrypanosomal compounds through experimental and in silico medicinal chemistry approaches. 2025, Anais.. Rio de Janeiro: Universidade Federal do Rio de Janeiro - UFRJ, 2025. Disponível em: https://repositorio.usp.br/directbitstream/51000f8f-7a74-4b44-a2e7-82d81e77adda/3289854.pdf. Acesso em: 18 fev. 2026. -
APA
Afonso, M., Costa, A. R., Silva-Silva, J. V., Duarte, S. M., Chelucci, R. C., Döring, T. H., et al. (2025). Investigation of novel antitrypanosomal compounds through experimental and in silico medicinal chemistry approaches. In Annals. Rio de Janeiro: Universidade Federal do Rio de Janeiro - UFRJ. Recuperado de https://repositorio.usp.br/directbitstream/51000f8f-7a74-4b44-a2e7-82d81e77adda/3289854.pdf -
NLM
Afonso M, Costa AR, Silva-Silva JV, Duarte SM, Chelucci RC, Döring TH, Ferreira LLG, Andricopulo AD. Investigation of novel antitrypanosomal compounds through experimental and in silico medicinal chemistry approaches [Internet]. Annals. 2025 ;[citado 2026 fev. 18 ] Available from: https://repositorio.usp.br/directbitstream/51000f8f-7a74-4b44-a2e7-82d81e77adda/3289854.pdf -
Vancouver
Afonso M, Costa AR, Silva-Silva JV, Duarte SM, Chelucci RC, Döring TH, Ferreira LLG, Andricopulo AD. Investigation of novel antitrypanosomal compounds through experimental and in silico medicinal chemistry approaches [Internet]. Annals. 2025 ;[citado 2026 fev. 18 ] Available from: https://repositorio.usp.br/directbitstream/51000f8f-7a74-4b44-a2e7-82d81e77adda/3289854.pdf - Identification of a novel antileishmanial compound through combined in vitro and in silico approaches
- Avaliação e planejamento de novos candidatos à fármacos para a leishmaniose visceral e doença de chagas
- Avaliação biológica e in silico de candidatos a novos fármacos para doenças de chagas
- Phenotypic screening of H1-antihistamines identifies promethazine and rupatadine as active compounds against Toxocara canis infective larvae
- Leishmanicidal benzodiazepines as DHFR-TS inhibitors: in vitro and in silico analysis
- Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease
- Discovery of arylpiperazines with broad-spectrum antimicrobial activity and favorable pharmacokinetic profiles
- Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum
- Novel deferasirox analogues designed as iron chelating agents for iron overload treatment
- Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents
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