Artigo de periodico

Isopropyl myristate continuous synthesis in a packed-bed reactor using lipase immobilized on magnetic polymer matrix (2018)

• Authors:
  • Silva, Mateus Vinicius Casagrande da
  • Souza, Caio Augusto P.
  • Oliveira, Pedro Carlos de
  • Castro, Heizir Ferreira de
  • Freitas, Larissa de
• USP affiliated authors: CASTRO, HEIZIR FERREIRA DE - EEL ; FREITAS, LARISSA DE - EEL ; SOUZA, CAIO AUGUSTO PRUDENTE DE - EEL ; SILVA, MATEUS VINICIUS CASAGRANDE DA - EEL
• Unidade: EEL
• Sigla do Departamento: LOQ
• DOI: 10.5281/zenodo.1474108
• Subjects: ESTERIFICAÇÃO; LIPASE
• Keywords: esterification; isopropyl myristate; lipase immobilized; magnetic particles; packed-bed reactor
• Agências de fomento:
  • Financiamento CAPES
  • Financiamento FAPESP
• Language: Inglês
• Abstract: The aim of this study was to synthesize isopropyl myristate, an emollient ester, in a continuous-flow packed-bed reactor using Candida antarctica lipase immobilized on poly(styrene-co-divinylbenzene) matrix prepared by suspension polymerization and magnetized by co-precipitation of Fe2+ and Fe3+ in alkaline medium. To determine the best esterification conditions, we investigated the effects of acid/alcohol molar ratio (1:5, 1:10, and 1:15) on reaction yield in shake flasks. The three tested conditions provided similar results, esterification yields of approximately 80%. An acid/alcohol molar ratio of 1:15 was chosen for further experiments because it allowed for better operability of the bioreactor. Subsequently, we compared the reactor performance in up flow and down flow modes. This experiment showed that greater ease of operation was achieved with down flow operation. We also evaluated the influence of space time (8 and 20 h) on reaction yield and productivity. A space time of 8 h provided better results. An experimental system consisting of two bioreactors and a molecular sieve packed column was used to remove the water formed during esterification and thus increase the yield of isopropyl myristate. There was a significant improvement in performance with the use of the two-stage system, which resulted in almost complete conversion of reagents, an increase of about 150% in biocatalyst half-life, and an isopropyl myristate productivity of 25 g L−1 h−1, confirming the beneficial effect of adding a water extraction column to the experimental system.
• Imprenta:
  • Publisher: IJOER
  • Publisher place: Bikaner
  • Date published: 2018
• Source:
  • Título: International journal of engineering research & science
  • ISSN: 2395-6992
  • Volume/Número/Paginação/Ano: v. 4, n. 10, p.12-20, 2018

Informações sobre o DOI: 10.5281/zenodo.1474108 (Fonte: oaDOI API)
• Este periódico é de acesso aberto
• Este artigo NÃO é de acesso aberto
  

---

How to cite

A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

• ABNT

  SILVA, Mateus Vinicius Casagrande da et al. Isopropyl myristate continuous synthesis in a packed-bed reactor using lipase immobilized on magnetic polymer matrix. International journal of engineering research & science, v. 4, n. 10, p. 12-20, 2018Tradução . . Disponível em: https://doi.org/10.5281/zenodo.1474108. Acesso em: 04 ago. 2025.

• APA

  Silva, M. V. C. da, Souza, C. A. P., Oliveira, P. C. de, Castro, H. F. de, & Freitas, L. de. (2018). Isopropyl myristate continuous synthesis in a packed-bed reactor using lipase immobilized on magnetic polymer matrix. International journal of engineering research & science, 4( 10), 12-20. doi:10.5281/zenodo.1474108

• NLM

  Silva MVC da, Souza CAP, Oliveira PC de, Castro HF de, Freitas L de. Isopropyl myristate continuous synthesis in a packed-bed reactor using lipase immobilized on magnetic polymer matrix [Internet]. International journal of engineering research & science. 2018 ; 4( 10): 12-20.[citado 2025 ago. 04 ] Available from: https://doi.org/10.5281/zenodo.1474108

• Vancouver

  Silva MVC da, Souza CAP, Oliveira PC de, Castro HF de, Freitas L de. Isopropyl myristate continuous synthesis in a packed-bed reactor using lipase immobilized on magnetic polymer matrix [Internet]. International journal of engineering research & science. 2018 ; 4( 10): 12-20.[citado 2025 ago. 04 ] Available from: https://doi.org/10.5281/zenodo.1474108

Últimas obras dos mesmos autores vinculados com a USP cadastradas na BDPI:

• Síntese de éster emoliente empregando lipase imobilizada em suporte polimérico magnetizado em biorreator de leito fixo operado continuamente
• Estudo cinético e termodinâmico da síntese do oleato de 2-etilhexila catalisada por lipase B de Candida antarctica imobilizada em copolímeros magnéticos
• Synthesis of 2-ethylhexyl oleate catalyzed by lipase immobilized on a magnetic support in packed-bed bioreactor
• Kinetic and Thermodynamic Study of 2-Ethylhexyl Oleate Synthesis Catalyzed by Candida antarctica Lipase Immobilized on a Magnetic Hybrid Support
• Síntese e caracterização do poli(estireno-co-triacrilato de trimetilolpropano) magnetizado para utilização como suporte de imobilização de enzimas
• Síntese de partículas poliméricas de estireno/TEGDMA com propriedades magnéticas para utilização como matriz de imobilização de lipases
• Síntese do palmitato de isopropila empregando lipase de Penicillium camemberti imobilizada em poli(estireno-co-divinilbenzeno) magnetizado
• Optimization of the parameters that affect the synthesis of magnetic copolymer styrene-divinilbezene to be used as efficient matrix for immobilizing lipases
• A fluidized bed reactor as an approach to enzymatic biodiesel production in a process with simultaneous glycerol removal
• Síntese do oleato de 2-etilhexila catalisada pela lipase imobilizada em suporte magnético conduzida em biorreator de leito fluidizado