Fish oil and EPA improve insulin sensitivity, in part through adipocyte mTORC2 activation in diet-induced obese male mice (2025)
- Authors:
- Castro, Érique de
- Vieira, Thayna dos Santos
- Peixoto, Albert Souza
- Leonardi, Bianca Franco
- Tomazelli, Caroline Aparecida
- Lino, Caroline Antunes
- Oliveira, Tiago E.
- Pessoa, Natália M.
- Pessoa, Érika Vicencia Monteiro
- Abe-Honda, Marina Akemi
- Corte, Natália Pontara
- Silva Junior, Luciano Pedro da
- Pires, Ana Brandão
- Chaves Filho, Adriano de Britto
- Moustaid-Moussa, Naima
- Festuccia, William Tadeu Lara
- Castro, Érique de
- USP affiliated authors: FESTUCCIA, WILLIAM TADEU LARA - ICB ; CASTRO, ÉRIQUE DE - ICB ; VIEIRA, THAYNA DOS SANTOS - ICB ; PEIXOTO, ÁLBERT SOUZA - ICB ; LEONARDI, BIANCA FRANCO - ICB ; TOMAZELLI, CAROLINE APARECIDA - ICB ; LINO, CAROLINE ANTUNES - ICB ; SILVA, TIAGO EUGÊNIO OLIVEIRA DA - IQ ; PESSOA, NATÁLIA MONTEIRO - ICB ; PESSOA, ÉRIKA VICÊNCIA MONTEIRO - ICB ; HONDA, MARINA AKEMI ABE - ICB ; CORTE, NATÁLIA PONTARA - ICB ; SILVA JUNIOR, LUCIANO PEDRO DA - ICB ; PIRES, ANA BRANDÃO - ICB ; CHAVES FILHO, ADRIANO DE BRITTO - IQ
- Unidades: ICB; IQ
- DOI: 10.1002/mnfr.70001
- Subjects: FISIOLOGIA; OBESIDADE; TECIDO ADIPOSO; ADIPOSIDADE; CAMUNDONGOS; FÍGADO GORDUROSO; PROTEÍNAS PROTO-ONCOGÊNICAS; ÓLEOS DE PEIXE; RESISTÊNCIA À INSULINA; ÁCIDOS GRAXOS OMEGA 3; MÚSCULO ESQUELÉTICO
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Molecular Nutrition & Food Research
- ISSN: 1613-4133
- Volume/Número/Paginação/Ano: v. 69, n. 6, art. e70001,
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
-
ABNT
CASTRO, Érique de et al. Fish oil and EPA improve insulin sensitivity, in part through adipocyte mTORC2 activation in diet-induced obese male mice. Molecular Nutrition & Food Research, v. 69, n. 6, 2025Tradução . . Disponível em: https://doi.org/10.1002/mnfr.70001. Acesso em: 09 fev. 2026. -
APA
Castro, É. de, Vieira, T. dos S., Peixoto, A. S., Leonardi, B. F., Tomazelli, C. A., Lino, C. A., et al. (2025). Fish oil and EPA improve insulin sensitivity, in part through adipocyte mTORC2 activation in diet-induced obese male mice. Molecular Nutrition & Food Research, 69( 6). doi:10.1002/mnfr.70001 -
NLM
Castro É de, Vieira T dos S, Peixoto AS, Leonardi BF, Tomazelli CA, Lino CA, Oliveira TE, Pessoa NM, Pessoa ÉVM, Abe-Honda MA, Corte NP, Silva Junior LP da, Pires AB, Chaves Filho A de B, Moustaid-Moussa N, Festuccia WTL. Fish oil and EPA improve insulin sensitivity, in part through adipocyte mTORC2 activation in diet-induced obese male mice [Internet]. Molecular Nutrition & Food Research. 2025 ; 69( 6):[citado 2026 fev. 09 ] Available from: https://doi.org/10.1002/mnfr.70001 -
Vancouver
Castro É de, Vieira T dos S, Peixoto AS, Leonardi BF, Tomazelli CA, Lino CA, Oliveira TE, Pessoa NM, Pessoa ÉVM, Abe-Honda MA, Corte NP, Silva Junior LP da, Pires AB, Chaves Filho A de B, Moustaid-Moussa N, Festuccia WTL. Fish oil and EPA improve insulin sensitivity, in part through adipocyte mTORC2 activation in diet-induced obese male mice [Internet]. Molecular Nutrition & Food Research. 2025 ; 69( 6):[citado 2026 fev. 09 ] Available from: https://doi.org/10.1002/mnfr.70001 - Deficiency of mTORC1 accelerates, while deficiency of mTORC2 blocks the development and progression of steatosis to steatohepatitis and hepatocellular carcinoma induced by PTEN-deletion in hepatocytes
- UCP1-independent mechanisms involved in the increased energy expenditure and protection against obesity induced by fish oil in mice
- Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning
- Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy
- Rictor/mTORC2 is a major mediator of hepatic steatosis, steatohepatitis and hepatocellular carcinoma progression induced by PTEN deletion in hepatocytes
- A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss
- PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity
- Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy
- Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in coldacclimated mice
- Deficiência da proteína peroxissomal Peroxina 5 (PEX5) em células mielóides reduz a inflamação e intolerância à glicose em camundongos alimentados com dieta hiperlipídica
Informações sobre o DOI: 10.1002/mnfr.70001 (Fonte: oaDOI API)
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