Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in coldacclimated mice (2021)
- Authors:
- Castro, Érique de
- Vieira, Thayna dos Santos
- Oliveira, Tiago E.
- Silva, Milene Ortiz
- Andrade, Maynara Lucca
- Tomazelli, Caroline Aparecida
- Peixoto, Albert Souza
- Sobrinho, Cleyton Roberto
- Moreno, Mayara Franzoi
- Gilio, Gustavo Renan
- Moreira, Rafael Junges
- Guimarães, Raphael Campos
- Perandini, Luiz Augusto Buoro
- Chimin, Patricia
- Reckziegel, Patricia
- Moretti, Eduardo Hermógenes
- Steiner, Alexandre Alarcon
- Laplante, Mathieu
- Festuccia, William Tadeu Lara
- Castro, Érique de
- USP affiliated authors: STEINER, ALEXANDRE ALARCON - ICB ; FESTUCCIA, WILLIAM TADEU LARA - ICB ; CASTRO, ÉRIQUE DE - ICB ; VIEIRA, THAYNA DOS SANTOS - ICB ; SILVA, MILENE ORTIZ - ICB ; TOMAZELLI, CAROLINE APARECIDA - ICB ; PEIXOTO, ÁLBERT SOUZA - ICB ; GILIO, GUSTAVO RENAN - ICB ; MOREIRA, RAFAEL JUNGES - ICB ; GUIMARÃES, RAPHAEL CAMPOS - ICB ; PERANDINI, LUIZ AUGUSTO BUORO - ICB ; MORETTI, EDUARDO HERMÓGENES - ICB
- Unidade: ICB
- DOI: 10.1152/ajpendo.00587.2020
- Subjects: IMUNOLOGIA; FISIOLOGIA; FÁRMACOS IMUNOSSUPRESSORES; TECIDO ADIPOSO; METABOLISMO ENERGÉTICO; EXPRESSÃO GÊNICA; GLICOSE; CAMUNDONGOS; TERMOGÊNESE; GENES; GORDURAS
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: AJP: Endocrinology and Metabolism
- ISSN: 1522-1555
- Volume/Número/Paginação/Ano: v. 321, p. E592–E605, 2021
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
CASTRO, Érique de et al. Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in coldacclimated mice. AJP: Endocrinology and Metabolism, v. 321, p. E592–E605, 2021Tradução . . Disponível em: https://doi.org/10.1152/ajpendo.00587.2020. Acesso em: 27 dez. 2025. -
APA
Castro, É. de, Vieira, T. dos S., Oliveira, T. E., Silva, M. O., Andrade, M. L., Tomazelli, C. A., et al. (2021). Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in coldacclimated mice. AJP: Endocrinology and Metabolism, 321, E592–E605. doi:10.1152/ajpendo.00587.2020 -
NLM
Castro É de, Vieira T dos S, Oliveira TE, Silva MO, Andrade ML, Tomazelli CA, Peixoto AS, Sobrinho CR, Moreno MF, Gilio GR, Moreira RJ, Guimarães RC, Perandini LAB, Chimin P, Reckziegel P, Moretti EH, Steiner AA, Laplante M, Festuccia WTL. Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in coldacclimated mice [Internet]. AJP: Endocrinology and Metabolism. 2021 ; 321 E592–E605.[citado 2025 dez. 27 ] Available from: https://doi.org/10.1152/ajpendo.00587.2020 -
Vancouver
Castro É de, Vieira T dos S, Oliveira TE, Silva MO, Andrade ML, Tomazelli CA, Peixoto AS, Sobrinho CR, Moreno MF, Gilio GR, Moreira RJ, Guimarães RC, Perandini LAB, Chimin P, Reckziegel P, Moretti EH, Steiner AA, Laplante M, Festuccia WTL. Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in coldacclimated mice [Internet]. AJP: Endocrinology and Metabolism. 2021 ; 321 E592–E605.[citado 2025 dez. 27 ] Available from: https://doi.org/10.1152/ajpendo.00587.2020 - Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning
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- Rictor/mTORC2 is a major mediator of hepatic steatosis, steatohepatitis and hepatocellular carcinoma progression induced by PTEN deletion in hepatocytes
- Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy
- A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation
- Mild-cold water swimming does not exacerbate white adipose tissue browning and brown adipose tissue activation in mice
- Interplay between brain oxygenation and the development of hypothermia in endotoxic shock
- Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy
- Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis
- UCP1-independent mechanisms involved in the increased energy expenditure and protection against obesity induced by fish oil in mice
Informações sobre o DOI: 10.1152/ajpendo.00587.2020 (Fonte: oaDOI API)
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