Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy (2023)
- Authors:
- Ortiz-Silva, Milene

- Leonardi, Bianca Franco

- Castro, Érique de

- Peixoto, Albert Souza

- Gilio, Gustavo Renan

- Oliveira, Tiago E.

- Tomazelli, Caroline Aparecida

- Andrade, Maynara Lucca
- Moreno, Mayara Franzoi

- Belchior, Thiago

- Magdalon, Juliana

- Vieira, Tayana S.
- Donado-Pestana, Carlos Mario

- Festuccia, William T.

- Ortiz-Silva, Milene
- USP affiliated authors: FESTUCCIA, WILLIAM TADEU LARA - ICB ; SILVA, MILENE ORTIZ - ICB ; LEONARDI, BIANCA FRANCO - ICB ; CASTRO, ÉRIQUE DE - ICB ; PEIXOTO, ÁLBERT SOUZA - ICB ; GILIO, GUSTAVO RENAN - ICB ; SILVA, TIAGO EUGÊNIO OLIVEIRA DA - ICB ; TOMAZELLI, CAROLINE APARECIDA - ICB ; MORENO, MAYARA FRANZOI - ICB ; OLIVEIRA, THIAGO BELCHIOR DE - ICB ; PESTANA, CARLOS MARIO DONADO - FCF
- Unidades: ICB; FCF
- DOI: 10.1016/j.mce.2023.112074
- Subjects: FISIOLOGIA; HOMEOSTASE; GLICOSE; LIPÍDEOS; ROEDORES; OBESIDADE; CAMUNDONGOS; DIETA ANIMAL; GORDURAS NA DIETA; ADIPOSIDADE; PESOS E MEDIDAS CORPORAIS; INSULINA; FIBROBLASTOS
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher: Elsevier Ireland Ltd.
- Publisher place: Amsterdam
- Date published: 2023
- Source:
- Título: Molecular and Cellular Endocrinology
- ISSN: 1872-8057
- Volume/Número/Paginação/Ano: v. 578, art. 112074, 11 p., 2023
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
ORTIZ-SILVA, Milene et al. Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy. Molecular and Cellular Endocrinology, v. 578, p. 11 , 2023Tradução . . Disponível em: https://doi.org/10.1016/j.mce.2023.112074. Acesso em: 27 dez. 2025. -
APA
Ortiz-Silva, M., Leonardi, B. F., Castro, É. de, Peixoto, A. S., Gilio, G. R., Oliveira, T. E., et al. (2023). Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy. Molecular and Cellular Endocrinology, 578, 11 . doi:10.1016/j.mce.2023.112074 -
NLM
Ortiz-Silva M, Leonardi BF, Castro É de, Peixoto AS, Gilio GR, Oliveira TE, Tomazelli CA, Andrade ML, Moreno MF, Belchior T, Magdalon J, Vieira TS, Donado-Pestana CM, Festuccia WT. Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy [Internet]. Molecular and Cellular Endocrinology. 2023 ; 578 11 .[citado 2025 dez. 27 ] Available from: https://doi.org/10.1016/j.mce.2023.112074 -
Vancouver
Ortiz-Silva M, Leonardi BF, Castro É de, Peixoto AS, Gilio GR, Oliveira TE, Tomazelli CA, Andrade ML, Moreno MF, Belchior T, Magdalon J, Vieira TS, Donado-Pestana CM, Festuccia WT. Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy [Internet]. Molecular and Cellular Endocrinology. 2023 ; 578 11 .[citado 2025 dez. 27 ] Available from: https://doi.org/10.1016/j.mce.2023.112074 - UCP1-independent mechanisms involved in the increased energy expenditure and protection against obesity induced by fish oil in mice
- Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning
- Fish oil protects wild type and uncoupling protein 1-deficient mice from obesity and glucose intolerance byIncreasing energy expenditure
- Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in coldacclimated mice
- Deficiency of mTORC1 accelerates, while deficiency of mTORC2 blocks the development and progression of steatosis to steatohepatitis and hepatocellular carcinoma induced by PTEN-deletion in hepatocytes
- Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis
- Rictor/mTORC2 is a major mediator of hepatic steatosis, steatohepatitis and hepatocellular carcinoma progression induced by PTEN deletion in hepatocytes
- PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity
- Lipoatrophy-associated insulin resistance and hepatic steatosis are attenuated by intake of diet rich in omega 3 fatty acids
- Jaboticaba (Plinia jaboticaba (Vell.) Berg) polyphenols alleviate skeletal muscle insulin resistance by modulating PI3K/Akt/GLUT‑4 and AMPK signaling pathways in diet‑induced obese mice
Informações sobre o DOI: 10.1016/j.mce.2023.112074 (Fonte: oaDOI API)
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas