Deficiency of mTORC1 accelerates, while deficiency of mTORC2 blocks the development and progression of steatosis to steatohepatitis and hepatocellular carcinoma induced by PTEN-deletion in hepatocytes (2023)
- Authors:
- Peixoto, Albert Souza
- Castro, Érique de
- Leonardi, Bianca Franco
- Gilio, Gustavo Renan
- Silva, Tiago Eugênio Oliveira da
- Tomazelli, Caroline Aparecida
- Vieira, Thayna dos Santos
- Moreno, Mayara Franzoi
- Silva Junior, Luciano Pedro da
- Pires, Ana Brandão
- Pessoa, Natália Monteiro
- Pessoa, Érika Vicência Monteiro
- Chaves Filho, Adriano de Britto
- Shida, Marcos Yukio
- Miyamoto, Sayuri
- Festuccia, William Tadeu Lara
- Peixoto, Albert Souza
- USP affiliated authors: MIYAMOTO, SAYURI - IQ ; FESTUCCIA, WILLIAM TADEU LARA - ICB ; PEIXOTO, ÁLBERT SOUZA - ICB ; CASTRO, ÉRIQUE DE - ICB ; LEONARDI, BIANCA FRANCO - ICB ; GILIO, GUSTAVO RENAN - ICB ; SILVA, TIAGO EUGÊNIO OLIVEIRA DA - ICB ; TOMAZELLI, CAROLINE APARECIDA - ICB ; VIEIRA, THAYNA DOS SANTOS - ICB ; SILVA JUNIOR, LUCIANO PEDRO DA - ICB ; PIRES, ANA BRANDÃO - ICB ; PESSOA, NATÁLIA MONTEIRO - ICB ; PESSOA, ÉRIKA VICÊNCIA MONTEIRO - ICB ; CHAVES FILHO, ADRIANO DE BRITTO - IQ
- Unidades: IQ; ICB
- Subjects: HEPATITE; CARCINOMA HEPATOCELULAR
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher: Sociedade Brasileira de Biociências Nucleares/SBBN
- Publisher place: São Paulo
- Date published: 2023
- Source:
- Conference titles: Reunião Anual da Federação de Sociedade de Biologia Experimental/FeSBE
-
ABNT
PEIXOTO, Albert Souza et al. Deficiency of mTORC1 accelerates, while deficiency of mTORC2 blocks the development and progression of steatosis to steatohepatitis and hepatocellular carcinoma induced by PTEN-deletion in hepatocytes. 2023, Anais.. São Paulo: Sociedade Brasileira de Biociências Nucleares/SBBN, 2023. Disponível em: https://proceedings.science/fesbe-2023/trabalhos?lang=pt-br. Acesso em: 27 dez. 2025. -
APA
Peixoto, A. S., Castro, É. de, Leonardi, B. F., Gilio, G. R., Silva, T. E. O. da, Tomazelli, C. A., et al. (2023). Deficiency of mTORC1 accelerates, while deficiency of mTORC2 blocks the development and progression of steatosis to steatohepatitis and hepatocellular carcinoma induced by PTEN-deletion in hepatocytes. In Anais. São Paulo: Sociedade Brasileira de Biociências Nucleares/SBBN. Recuperado de https://proceedings.science/fesbe-2023/trabalhos?lang=pt-br -
NLM
Peixoto AS, Castro É de, Leonardi BF, Gilio GR, Silva TEO da, Tomazelli CA, Vieira T dos S, Moreno MF, Silva Junior LP da, Pires AB, Pessoa NM, Pessoa ÉVM, Chaves Filho A de B, Shida MY, Miyamoto S, Festuccia WTL. Deficiency of mTORC1 accelerates, while deficiency of mTORC2 blocks the development and progression of steatosis to steatohepatitis and hepatocellular carcinoma induced by PTEN-deletion in hepatocytes [Internet]. Anais. 2023 ;[citado 2025 dez. 27 ] Available from: https://proceedings.science/fesbe-2023/trabalhos?lang=pt-br -
Vancouver
Peixoto AS, Castro É de, Leonardi BF, Gilio GR, Silva TEO da, Tomazelli CA, Vieira T dos S, Moreno MF, Silva Junior LP da, Pires AB, Pessoa NM, Pessoa ÉVM, Chaves Filho A de B, Shida MY, Miyamoto S, Festuccia WTL. Deficiency of mTORC1 accelerates, while deficiency of mTORC2 blocks the development and progression of steatosis to steatohepatitis and hepatocellular carcinoma induced by PTEN-deletion in hepatocytes [Internet]. Anais. 2023 ;[citado 2025 dez. 27 ] Available from: https://proceedings.science/fesbe-2023/trabalhos?lang=pt-br - UCP1-independent mechanisms involved in the increased energy expenditure and protection against obesity induced by fish oil in mice
- Fish oil and EPA improve insulin sensitivity, in part through adipocyte mTORC2 activation in diet-induced obese male mice
- Rictor/mTORC2 is a major mediator of hepatic steatosis, steatohepatitis and hepatocellular carcinoma progression induced by PTEN deletion in hepatocytes
- Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy
- PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity
- Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning
- Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy
- Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in coldacclimated mice
- Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis
- Liver lipidome signature and metabolic pathways in non-alcoholic fatty liver disease induced by a high-sugar diet
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