Upconverting Nanocarriers Enable Triggered Microtubule Inhibition and Concurrent Ferroptosis Induction for Selective Treatment of Triple-Negative Breast Cancer (2020)
- Authors:
- Autor USP: SAMPAIO, SIMONE DE FÁTIMA MEDEIROS - EEL
- Unidade: EEL
- DOI: 10.1021/acs.nanolett.0c00502
- Subjects: FÁRMACOS; NEOPLASIAS
- Keywords: Upconverting nanocarriers; microtubule inhibitor; ferroptosis; triple-negative breast cancer; drug delivery
- Agências de fomento:
- Language: Inglês
- Abstract: Despite the resistance of triple-negative breast cancer (TNBC) to targeted hormone therapy, the discovery of azobenzene combretastatin A4 (Azo-CA4) provides therapeutic opportunities for TNBC. Here, Azo-CA4 was loaded in upconverting nanocarriers that could convert near-infrared (NIR) light to UV light to activate Azo-CA4. Upon irradiation, Azo-CA4-loaded nanocarriers significantly reduced the viability of TNBC cells via both apoptosis and ferroptosis. The former was induced by photoisomerization of Azo-CA4, accompanied by microtubule breakdown and cell cycle arrest at G2/M phase. The latter was caused by the UV light-induced reduction of Fe3+ to Fe2+ that facilitates the peroxidation of tailored lipids. The cooperation between apoptosis and ferroptosis in eliminating TNBC was demonstrated in a xenograft mice model in terms of histological staining, tumor growth inhibition, and animal survival. Since the NIR light is only applied to the tumor site, the adverse effects of such triggered nanocarriers to the healthy organs are negligible.
- Imprenta:
- Publisher: ACS Publications
- Publisher place: Washington-DC
- Date published: 2020
- Source:
- Título: Nano Letters
- ISSN: 1530-6984
- Volume/Número/Paginação/Ano: v. 20, n. 9, p.6235-6245, 2020
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
ZHU, Jundong et al. Upconverting Nanocarriers Enable Triggered Microtubule Inhibition and Concurrent Ferroptosis Induction for Selective Treatment of Triple-Negative Breast Cancer. Nano Letters, v. 20, n. 9, p. 6235-6245, 2020Tradução . . Disponível em: https://doi.org/10.1021/acs.nanolett.0c00502. Acesso em: 30 dez. 2025. -
APA
Zhu, J., Wang, Z., Zhao, Y., Dai, P., Liu, F., Li, Y., et al. (2020). Upconverting Nanocarriers Enable Triggered Microtubule Inhibition and Concurrent Ferroptosis Induction for Selective Treatment of Triple-Negative Breast Cancer. Nano Letters, 20( 9), 6235-6245. doi:10.1021/acs.nanolett.0c00502 -
NLM
Zhu J, Wang Z, Zhao Y, Dai P, Liu F, Li Y, Qin Y, Yang Q, Tian R, Fan A, Medeiros S de F. Upconverting Nanocarriers Enable Triggered Microtubule Inhibition and Concurrent Ferroptosis Induction for Selective Treatment of Triple-Negative Breast Cancer [Internet]. Nano Letters. 2020 ; 20( 9): 6235-6245.[citado 2025 dez. 30 ] Available from: https://doi.org/10.1021/acs.nanolett.0c00502 -
Vancouver
Zhu J, Wang Z, Zhao Y, Dai P, Liu F, Li Y, Qin Y, Yang Q, Tian R, Fan A, Medeiros S de F. Upconverting Nanocarriers Enable Triggered Microtubule Inhibition and Concurrent Ferroptosis Induction for Selective Treatment of Triple-Negative Breast Cancer [Internet]. Nano Letters. 2020 ; 20( 9): 6235-6245.[citado 2025 dez. 30 ] Available from: https://doi.org/10.1021/acs.nanolett.0c00502 - A promising sustainable PHB-ZnO composite for development of biodegradable filaments
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Informações sobre o DOI: 10.1021/acs.nanolett.0c00502 (Fonte: oaDOI API)
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