Artigo de periodico

Recent advances in the production of biomedical systems based on polyhydroxyalkanoates and exopolysaccharides (2023)

• Authors:
  • Carvalho, Layde T.
  • Vieira, Thiago A.
  • Zhao, Yanjun
  • Medeiros, Simone de Fátima
  • Celli, Annamaria
  • Lacerda, Talita Martins
• USP affiliated authors: SAMPAIO, SIMONE DE FÁTIMA MEDEIROS - EEL ; LACERDA, TALITA MARTINS - EEL ; CARVALHO, LAYDE TEIXEIRA DE - EEL ; VIEIRA, THIAGO ANTONIO - EEL
• Unidade: EEL
• DOI: 10.1016/j.ijbiomac.2021.05.025
• Assunto: ENGENHARIA QUÍMICA
• Keywords: Biomedical devices; Exopolysaccharides; Polyhydroxyalkanoates; Drug delivery
• Agências de fomento:
  • Financiamento CNPq
  • Financiamento FAPESP
• Language: Inglês
• Abstract: In recent years, growing attention has been devoted to naturally occurring biological macromolecules and their ensuing application in agriculture, cosmetics, food and pharmaceutical industries. They inherently have antigenicity, low immunogenicity, excellent biocompatibility and cytocompatibility, which are ideal properties for the design of biomedical devices, especially for the controlled delivery of active ingredients in the most diverse contexts. Furthermore, these properties can be modulated by chemical modification via the incorporation of other (macro)molecules in a random or controlled way, aiming at improving their functionality for each specific application. Among the wide variety of natural polymers, microbial polyhydroxyalkanoates (PHAs) and exopolysaccharides (EPS) are often considered for the development of original biomaterials due to their unique physicochemical and biological features. Here, we aim to fullfil a gap on the present associated literature, bringing an up-to-date overview of ongoing research strategies that make use of PHAs (poly (3-hydroxybutyrate), poly (3-hydroxybutyrate-co-3-hydroxyvalerate), poly (3-hydroxyoctanoate), poly(3-hydroxypropionate), poly (3-hydroxyhexanoate-co-3-hydroxyoctanoate), and poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)) and EPS (bacterial cellulose, alginates, curdlan, pullulan, xanthan gum, dextran, hyaluronan, and schizophyllan) as sources of interesting and versatile biomaterials. For the first time, a monograph addressing the properties, pros and cons, status, challenges, and recent progresses regarding the application of these two important classes of biopolymers in biomedicine is presented.
• Imprenta:
  • Publisher: Elsevier
  • Publisher place: Wells
  • Date published: 2023
• Source:
  • Título: International journal of biological macromolecules
  • ISSN: 0141-8130
  • Volume/Número/Paginação/Ano: v.183, p.1514-1539, 2021

Informações sobre o DOI: 10.1016/j.ijbiomac.2021.05.025 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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How to cite

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• ABNT

  CARVALHO, Layde T. et al. Recent advances in the production of biomedical systems based on polyhydroxyalkanoates and exopolysaccharides. International journal of biological macromolecules, v. 183, p. 1514-1539, 2023Tradução . . Disponível em: https://doi.org/10.1016/j.ijbiomac.2021.05.025. Acesso em: 30 dez. 2025.

• APA

  Carvalho, L. T., Vieira, T. A., Zhao, Y., Medeiros, S. de F., Celli, A., & Lacerda, T. M. (2023). Recent advances in the production of biomedical systems based on polyhydroxyalkanoates and exopolysaccharides. International journal of biological macromolecules, 183, 1514-1539. doi:10.1016/j.ijbiomac.2021.05.025

• NLM

  Carvalho LT, Vieira TA, Zhao Y, Medeiros S de F, Celli A, Lacerda TM. Recent advances in the production of biomedical systems based on polyhydroxyalkanoates and exopolysaccharides [Internet]. International journal of biological macromolecules. 2023 ;183 1514-1539.[citado 2025 dez. 30 ] Available from: https://doi.org/10.1016/j.ijbiomac.2021.05.025

• Vancouver

  Carvalho LT, Vieira TA, Zhao Y, Medeiros S de F, Celli A, Lacerda TM. Recent advances in the production of biomedical systems based on polyhydroxyalkanoates and exopolysaccharides [Internet]. International journal of biological macromolecules. 2023 ;183 1514-1539.[citado 2025 dez. 30 ] Available from: https://doi.org/10.1016/j.ijbiomac.2021.05.025

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