Artigo de periodico

Development of pullulan-based carriers for controlled release of hydrophobic ingredients (2021)

• Authors:
  • Carvalho, Layde T.
  • Moraes, Rodolfo Minto de
  • Teixeira, Ana Julia R. M.
  • Tada, Dayane Batista
  • Alves, Gizelda Maria
  • Lacerda, Talita Martins
  • Santos, Julio Cesar dos
  • Santos, Amilton Martins dos
  • Medeiros, Simone de Fátima
• USP affiliated authors: LACERDA, TALITA MARTINS - EEL ; SANTOS, JÚLIO CÉSAR DOS - EEL ; SANTOS, AMILTON MARTINS DOS - EEL ; SAMPAIO, SIMONE DE FÁTIMA MEDEIROS - EEL ; TEIXEIRA, ANA JÚLIA ROMAIN MARCONDES - EEL ; CARVALHO, LAYDE TEIXEIRA DE - EEL ; MORAES, RODOLFO MINTO DE - EEL
• Unidade: EEL
• DOI: 10.1002/app.51344
• Subjects: POLISSACARÍDEOS; NANOPARTÍCULAS; POLÍMEROS (QUÍMICA ORGÂNICA)
• Keywords: polysaccharides; self-assembly; biocompatibility; drug delivery systems; nanoparticles; nanowires; nanocrystals
• Agências de fomento:
  • Financiamento CAPES
  • Financiamento FAPESP
• Language: Inglês
• Abstract: Polymeric nanoparticles have great potential for targeted and controlled delivery of drugs for several health treatments. In this work, pullulan-graft-poly(ε-caprolactone) (Pull-g-PCL) nanoparticles were prepared and used to encapsulate indomethacin via dialysis. The nanoparticles were characterized with respect to size, size distribution, and morphology, using dynamic light scattering and transmission electron microscopy. The average diameter of nanoparticles was 220.0 and 273.7 nm, with and without indomethacin, respectively. Encapsulation of indomethacin and its release from the nanoparticles were studied, and the calculated value of indomethacin efficiency encapsulation was 35.05 wt%. The ensuing release kinetics were evaluated in vitro at 37°C and pH 7.4 and evidenced the efficiency of polymer nanoparticles in reducing the release rate of the ingredient. Pull-g-PCL nanoparticles represent, therefore, promising materials with potential for application in controlled release systems of hydrophobic substances.
• Imprenta:
  • Publisher place: Wiley
  • Date published: 2021
• Source:
  • Título: Journal of applied polymer science
  • ISSN: 0021-8995
  • Volume/Número/Paginação/Ano: v.138, n.45, art. n. 51344, p.1-12, 2021

Informações sobre o DOI: 10.1002/app.51344 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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How to cite

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• ABNT

  CARVALHO, Layde T. et al. Development of pullulan-based carriers for controlled release of hydrophobic ingredients. Journal of applied polymer science, v. 138, n. art. 51344, p. 1-12, 2021Tradução . . Disponível em: https://doi.org/10.1002/app.51344. Acesso em: 29 dez. 2025.

• APA

  Carvalho, L. T., Moraes, R. M. de, Teixeira, A. J. R. M., Tada, D. B., Alves, G. M., Lacerda, T. M., et al. (2021). Development of pullulan-based carriers for controlled release of hydrophobic ingredients. Journal of applied polymer science, 138( art. 51344), 1-12. doi:10.1002/app.51344

• NLM

  Carvalho LT, Moraes RM de, Teixeira AJRM, Tada DB, Alves GM, Lacerda TM, Santos JC dos, Santos AM dos, Medeiros S de F. Development of pullulan-based carriers for controlled release of hydrophobic ingredients [Internet]. Journal of applied polymer science. 2021 ;138( art. 51344): 1-12.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1002/app.51344

• Vancouver

  Carvalho LT, Moraes RM de, Teixeira AJRM, Tada DB, Alves GM, Lacerda TM, Santos JC dos, Santos AM dos, Medeiros S de F. Development of pullulan-based carriers for controlled release of hydrophobic ingredients [Internet]. Journal of applied polymer science. 2021 ;138( art. 51344): 1-12.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1002/app.51344

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