Natural compounds as non-nucleoside inhibitors of zika virus polymerase through integration of in silico and in vitro approaches (2022)
- Authors:
- Ramos, Paulo Ricardo Pimenta da Silva
- Mottin, Melina
- Lima, Caroline Sprengel
- Assis, Letícia R.
- Oliveira, Ketllyn Zagato de
- Mesquita, Nathalya Cristina de Moraes Roso
- Cassani, Natasha Marques
- Santos, Igor Andrade
- Borba, Joyce Villa Verde Bastos
- Costa, Vinícius Alexandre Fiaia
- Junior Neves, Bruno
- Guido, Rafael Victorio Carvalho
- Oliva, Glaucius
- Jardim, Ana Carolina Gomes
- Regasini, Luis Octávio
- Andrade, Carolina Horta
- Ramos, Paulo Ricardo Pimenta da Silva
- USP affiliated authors: GUIDO, RAFAEL VICTÓRIO CARVALHO - IFSC ; OLIVA, GLAUCIUS - IFSC ; OLIVEIRA, KETLLYN IRENE ZAGATO DE - IFSC ; MESQUITA, NATHALYA CRISTINA DE MORAES ROSO - IFSC
- Unidade: IFSC
- DOI: 10.3390/ph15121493
- Subjects: ZIKA VÍRUS; PLANEJAMENTO DE FÁRMACOS; QUÍMICA MÉDICA
- Keywords: Zika virus; Antiviral; Polymerase; Docking; Drug discovery; NS5 RdRp protein; Flavonoid; Pedalitin; Quercetin; Non-nucleoside inhibitor
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Pharmaceuticals
- ISSN: 1424-8247
- Volume/Número/Paginação/Ano: v. 15, n. 12, p. 1493-1-1493-17, Dec. 2022
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
-
ABNT
RAMOS, Paulo Ricardo Pimenta da Silva et al. Natural compounds as non-nucleoside inhibitors of zika virus polymerase through integration of in silico and in vitro approaches. Pharmaceuticals, v. 15, n. 12, p. 1493-1-1493-17, 2022Tradução . . Disponível em: https://doi.org/10.3390/ph15121493. Acesso em: 14 fev. 2026. -
APA
Ramos, P. R. P. da S., Mottin, M., Lima, C. S., Assis, L. R., Oliveira, K. Z. de, Mesquita, N. C. de M. R., et al. (2022). Natural compounds as non-nucleoside inhibitors of zika virus polymerase through integration of in silico and in vitro approaches. Pharmaceuticals, 15( 12), 1493-1-1493-17. doi:10.3390/ph15121493 -
NLM
Ramos PRP da S, Mottin M, Lima CS, Assis LR, Oliveira KZ de, Mesquita NC de MR, Cassani NM, Santos IA, Borba JVVB, Costa VAF, Junior Neves B, Guido RVC, Oliva G, Jardim ACG, Regasini LO, Andrade CH. Natural compounds as non-nucleoside inhibitors of zika virus polymerase through integration of in silico and in vitro approaches [Internet]. Pharmaceuticals. 2022 ; 15( 12): 1493-1-1493-17.[citado 2026 fev. 14 ] Available from: https://doi.org/10.3390/ph15121493 -
Vancouver
Ramos PRP da S, Mottin M, Lima CS, Assis LR, Oliveira KZ de, Mesquita NC de MR, Cassani NM, Santos IA, Borba JVVB, Costa VAF, Junior Neves B, Guido RVC, Oliva G, Jardim ACG, Regasini LO, Andrade CH. Natural compounds as non-nucleoside inhibitors of zika virus polymerase through integration of in silico and in vitro approaches [Internet]. Pharmaceuticals. 2022 ; 15( 12): 1493-1-1493-17.[citado 2026 fev. 14 ] Available from: https://doi.org/10.3390/ph15121493 - Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins
- Synthesis and evaluation of new ligands of the Zika virus NS3 helicase protein
- Total synthesis of Licochalcone G, enzymatic assays, and molecular docking studies against the Zika virus
- Licochalcone H and analogs as Zika virus NS2B-NS3 protease inhibitors: molecular docking and phenotypic assay
- Regioselective total synthesis and broad antiviral effects of Licochalcone C
- Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors
- Discovery of new Zika protease and polymerase inhibitors through the open science collaboration Project OpenZika
- Discovery of new Zika virus candidates: natural products from Angelica keiskei with activity against NS2B-NS3 protease
- Discovery of flavonoids from Pterogyne nitens with potent activity against Zika virus protease and helicase
- Metiltransferase de flavivírus como obtê-las?
Informações sobre o DOI: 10.3390/ph15121493 (Fonte: oaDOI API)
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