Artigo de periodico

Discovery of new Zika protease and polymerase inhibitors through the open science collaboration Project OpenZika (2022)

• Authors:
  • Mottin, Melina
  • Sousa, Bruna Katiele de Paula
  • Mesquita, Nathalya Cristina de Moraes Roso
  • Oliveira, Ketllyn Irene Zagato de
  • Noske, Gabriela Dias
  • Sartori, Geraldo Rodrigues
  • Albuquerque, Aline de Oliveira
  • Urbina, Fabio
  • Puhl, Ana C.
  • Moreira Filho, José Teófilo
  • Souza, Guilherme Eduardo de
  • Guido, Rafael Victorio Carvalho
  • Muratov, Eugene
  • Neves, Bruno Junior
  • Silva, João Hermínio Martins da
  • Clark, Alex E.
  • Siqueira Neto, Jair L.
  • Perryman, Alexander L.
  • Oliva, Glaucius
  • Ekins, Sean
  • Andrade, Carolina Horta
• USP affiliated authors: GUIDO, RAFAEL VICTÓRIO CARVALHO - IFSC ; OLIVA, GLAUCIUS - IFSC ; MESQUITA, NATHALYA CRISTINA DE MORAES ROSO - IFSC ; OLIVEIRA, KETLLYN IRENE ZAGATO DE - IFSC ; NOSKE, GABRIELA DIAS - IFSC ; SOUZA, GUILHERME EDUARDO DE - IFSC
• Unidade: IFSC
• DOI: 10.1021/acs.jcim.2c00596
• Subjects: ZIKA VÍRUS; PLANEJAMENTO DE FÁRMACOS; ANTIVIRAIS
• Agências de fomento:
  • Financiamento CNPq
  • Financiamento FAPEG
  • Financiamento FAPESP
  • Financiamento CAPES
  • Financiamento NIH
• Language: Inglês
• Imprenta:
  • Publisher place: Washington, DC
  • Date published: 2022
• Source:
  • Título: Journal of Chemical Information and Modeling
  • ISSN: 1549-9596
  • Volume/Número/Paginação/Ano: v. 62, n. 24, p. 6825-6843, Dec. 2022

Informações sobre o DOI: 10.1021/acs.jcim.2c00596 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo é de acesso aberto
• URL de acesso aberto
• Cor do Acesso Aberto: green

---

Download do texto completo

Tipo	Nome	Link
	3113061.pdf

How to cite

A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

• ABNT

  MOTTIN, Melina et al. Discovery of new Zika protease and polymerase inhibitors through the open science collaboration Project OpenZika. Journal of Chemical Information and Modeling, v. 62, n. 24, p. 6825-6843, 2022Tradução . . Disponível em: https://doi.org/10.1021/acs.jcim.2c00596. Acesso em: 28 dez. 2025.

• APA

  Mottin, M., Sousa, B. K. de P., Mesquita, N. C. de M. R., Oliveira, K. I. Z. de, Noske, G. D., Sartori, G. R., et al. (2022). Discovery of new Zika protease and polymerase inhibitors through the open science collaboration Project OpenZika. Journal of Chemical Information and Modeling, 62( 24), 6825-6843. doi:10.1021/acs.jcim.2c00596

• NLM

  Mottin M, Sousa BK de P, Mesquita NC de MR, Oliveira KIZ de, Noske GD, Sartori GR, Albuquerque A de O, Urbina F, Puhl AC, Moreira Filho JT, Souza GE de, Guido RVC, Muratov E, Neves BJ, Silva JHM da, Clark AE, Siqueira Neto JL, Perryman AL, Oliva G, Ekins S, Andrade CH. Discovery of new Zika protease and polymerase inhibitors through the open science collaboration Project OpenZika [Internet]. Journal of Chemical Information and Modeling. 2022 ; 62( 24): 6825-6843.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1021/acs.jcim.2c00596

• Vancouver

  Mottin M, Sousa BK de P, Mesquita NC de MR, Oliveira KIZ de, Noske GD, Sartori GR, Albuquerque A de O, Urbina F, Puhl AC, Moreira Filho JT, Souza GE de, Guido RVC, Muratov E, Neves BJ, Silva JHM da, Clark AE, Siqueira Neto JL, Perryman AL, Oliva G, Ekins S, Andrade CH. Discovery of new Zika protease and polymerase inhibitors through the open science collaboration Project OpenZika [Internet]. Journal of Chemical Information and Modeling. 2022 ; 62( 24): 6825-6843.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1021/acs.jcim.2c00596

Últimas obras dos mesmos autores vinculados com a USP cadastradas na BDPI:

• Natural compounds as non-nucleoside inhibitors of zika virus polymerase through integration of in silico and in vitro approaches
• Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins
• Total synthesis of Licochalcone G, enzymatic assays, and molecular docking studies against the Zika virus
• Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors
• Synthesis and evaluation of new ligands of the Zika virus NS3 helicase protein
• Regioselective total synthesis and broad antiviral effects of Licochalcone C
• Licochalcone H and analogs as Zika virus NS2B-NS3 protease inhibitors: molecular docking and phenotypic assay
• The GA-hecate peptide inhibits the ZIKV replicative cycle in different steps and can inhibit the flavivirus NS2B-NS3 protease after cell infection
• High-throughput antiviral assays to screen for inhibitors of Zika virus replication
• Structural biology and ligand search for the NS5 protein of the Zika virus