Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells (2022)
- Authors:
- USP affiliated authors: REGO, EDUARDO MAGALHÃES - FM ; PONTES, LORENA LÔBO DE FIGUEIREDO - FMRP ; MACHADO NETO, JOÃO AGOSTINHO - ICB ; TRAINA, FABÍOLA - FMRP ; FENERICH, BRUNA ALVES - FMRP ; SILVA, ANTONIO BRUNO ALVES DA - FMRP ; FONSECA, NATASHA PEIXOTO - FMRP ; FERNANDES, JAQUELINE CRISTINA - FMRP ; SILVA, JUAN LUIZ COELHO DA - FMRP
- Unidades: FM; FMRP; ICB
- DOI: 10.1016/j.tiv.2022.105384
- Subjects: FARMACOLOGIA; ANTINEOPLÁSICOS; INIBIDORES QUÍMICOS; MEDULA ÓSSEA; CÉLULAS-TRONCO; PROLIFERAÇÃO CELULAR; APOPTOSE; MUTAÇÃO; CÉLULAS MIELOIDES; FATORES DE CRESCIMENTO
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título do periódico: Toxicology in Vitro
- ISSN: 1879-3177
- Volume/Número/Paginação/Ano: v. 83, art. 105384, p. 1-7, 2022
- Este periódico é de assinatura
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: bronze
- Licença: publisher-specific-oa
-
ABNT
FERNANDES, Jaqueline Cristina et al. Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells. Toxicology in Vitro, v. 83, p. 1-7, 2022Tradução . . Disponível em: https://doi.org/10.1016/j.tiv.2022.105384. Acesso em: 19 set. 2024. -
APA
Fernandes, J. C., Fenerich, B. A., Silva, A. B. A., Fonseca, N. P., Silva, J. L. C., Scheucher, P. S., et al. (2022). Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells. Toxicology in Vitro, 83, 1-7. doi:10.1016/j.tiv.2022.105384 -
NLM
Fernandes JC, Fenerich BA, Silva ABA, Fonseca NP, Silva JLC, Scheucher PS, Rego EM, Pontes LLF, Machado Neto JA, Traina F. Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells [Internet]. Toxicology in Vitro. 2022 ; 83 1-7.[citado 2024 set. 19 ] Available from: https://doi.org/10.1016/j.tiv.2022.105384 -
Vancouver
Fernandes JC, Fenerich BA, Silva ABA, Fonseca NP, Silva JLC, Scheucher PS, Rego EM, Pontes LLF, Machado Neto JA, Traina F. Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells [Internet]. Toxicology in Vitro. 2022 ; 83 1-7.[citado 2024 set. 19 ] Available from: https://doi.org/10.1016/j.tiv.2022.105384 - Irs1S57X heterozygous mutant mice display normal hematopoiesis and phenotypic features, while homozygous knockout exhibit high fetal or postnatal lethality
- Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2(V617F) driven cells
- NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia
- Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model
- IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells
- Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
- NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells
- Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2V617F cells
- Padronização de modelo xenográfico sistêmico de leucemia linfoide aguda
- A inibição farmacológica de IRS1/2 induz apoptose em células BCR-ABL1 T315I
Informações sobre o DOI: 10.1016/j.tiv.2022.105384 (Fonte: oaDOI API)
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