IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells (2019)
- Authors:
- USP affiliated authors: SCHEUCHER, PRISCILA SANTOS - FMRP ; SIMOES, BELINDA PINTO - FMRP ; REGO, EDUARDO MAGALHÃES - FM ; TRAINA, FABÍOLA - FMRP ; MACHADO NETO, JOÃO AGOSTINHO - ICB ; ALVES, ANA PAULA NUNES RODRIGUES - FMRP ; FERNANDES, JAQUELINE CRISTINA - FMRP ; FENERICH, BRUNA ALVES - FMRP ; SILVA, JUAN LUIZ COELHO DA - FMRP ; MACHADO NETO, JOÃO AGOSTINHO - FMRP
- Unidades: FMRP; FM; ICB
- DOI: 10.1016/j.canlet.2019.04.030
- Subjects: LEUCEMIA; CÉLULAS SANGUINEAS; CITOTOXINAS; APOPTOSE; CÉLULAS CULTIVADAS DE TUMOR; ONCOGENES
- Keywords: Acute lymphoblastic leukemia; Cell signaling
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Cancer Letters
- ISSN: 0304-3835
- Volume/Número/Paginação/Ano: v. 456, p. 59-68, 2019
- Este periódico é de assinatura
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: hybrid
- Licença: unspecified-oa
-
ABNT
ALVES, Ana Paula Nunes Rodrigues et al. IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells. Cancer Letters, v. 456, p. 59-68, 2019Tradução . . Disponível em: https://doi.org/10.1016/j.canlet.2019.04.030. Acesso em: 31 dez. 2025. -
APA
Alves, A. P. N. R., Fernandes, J. C., Fenerich, B. A., Silva, J. L. C. da, Scheucher, P. S., Simões, B. P., et al. (2019). IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells. Cancer Letters, 456, 59-68. doi:10.1016/j.canlet.2019.04.030 -
NLM
Alves APNR, Fernandes JC, Fenerich BA, Silva JLC da, Scheucher PS, Simões BP, Rego EM, Ridley AJ, Machado Neto JA, Traina F. IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells [Internet]. Cancer Letters. 2019 ; 456 59-68.[citado 2025 dez. 31 ] Available from: https://doi.org/10.1016/j.canlet.2019.04.030 -
Vancouver
Alves APNR, Fernandes JC, Fenerich BA, Silva JLC da, Scheucher PS, Simões BP, Rego EM, Ridley AJ, Machado Neto JA, Traina F. IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells [Internet]. Cancer Letters. 2019 ; 456 59-68.[citado 2025 dez. 31 ] Available from: https://doi.org/10.1016/j.canlet.2019.04.030 - NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells
- NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia
- Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
- Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells
- Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2V617F cells
- Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2(V617F) driven cells
- A ativação da via IGF1R prediz prognóstico e representa uma estratégia terapêutica em leucemia mieloide aguda
- A inibição farmacológica de IRS1/2 induz apoptose em células BCR-ABL1 T315I
- IGF signaling predicts outcomes and is a promising target therapy for acute myeloid leukemia
- The pharmacological IGF1R-IRS1/2 inhibitor NT157 presents multiple anti-neoplastic effects in myeloproliferative neoplasms
Informações sobre o DOI: 10.1016/j.canlet.2019.04.030 (Fonte: oaDOI API)
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