NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells (2020)
- Authors:
- USP affiliated authors: SCHEUCHER, PRISCILA SANTOS - FMRP ; REGO, EDUARDO MAGALHÃES - FM ; MACHADO NETO, JOÃO AGOSTINHO - ICB ; TRAINA, FABÍOLA - FMRP ; FENERICH, BRUNA ALVES - FMRP ; FERNANDES, JAQUELINE CRISTINA - FMRP ; ALVES, ANA PAULA NUNES RODRIGUES - FMRP ; SILVA, JUAN LUIZ COELHO DA - FMRP ; RIBEIRO, RENATA SCOPIM - FMRP
- Unidades: FMRP; FM; ICB
- DOI: 10.1038/s41392-019-0102-5
- Subjects: FARMACOLOGIA; TRANSDUÇÃO DE SINAL CELULAR; CÉLULAS CULTIVADAS DE TUMOR; ANTINEOPLÁSICOS; PROLIFERAÇÃO CELULAR; ERITROPOIETINA; APOPTOSE; MUTAÇÃO GENÉTICA
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Signal Transduction and Targeted Therapy
- ISSN: 2059-3635
- Volume/Número/Paginação/Ano: art. 5, 10 p., 2020
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by
-
ABNT
FENERICH, Bruna Alves et al. NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells. Signal Transduction and Targeted Therapy, p. 10 , 2020Tradução . . Disponível em: https://doi.org/10.1038/s41392-019-0102-5. Acesso em: 31 dez. 2025. -
APA
Fenerich, B. A., Fernandes, J. C., Alves, A. P. N. R., Silva, J. L. C. da, Ribeiro, R. S., Scheucher, P. S., et al. (2020). NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells. Signal Transduction and Targeted Therapy, 10 . doi:10.1038/s41392-019-0102-5 -
NLM
Fenerich BA, Fernandes JC, Alves APNR, Silva JLC da, Ribeiro RS, Scheucher PS, Eide CA, Tognon CE, Druker BJ, Rego EM, Machado Neto JA, Traina F. NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells [Internet]. Signal Transduction and Targeted Therapy. 2020 ; 10 .[citado 2025 dez. 31 ] Available from: https://doi.org/10.1038/s41392-019-0102-5 -
Vancouver
Fenerich BA, Fernandes JC, Alves APNR, Silva JLC da, Ribeiro RS, Scheucher PS, Eide CA, Tognon CE, Druker BJ, Rego EM, Machado Neto JA, Traina F. NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells [Internet]. Signal Transduction and Targeted Therapy. 2020 ; 10 .[citado 2025 dez. 31 ] Available from: https://doi.org/10.1038/s41392-019-0102-5 - Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
- IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells
- Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2(V617F) driven cells
- NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia
- Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2V617F cells
- A ativação da via IGF1R prediz prognóstico e representa uma estratégia terapêutica em leucemia mieloide aguda
- A inibição farmacológica de IRS1/2 induz apoptose em células BCR-ABL1 T315I
- IGF signaling predicts outcomes and is a promising target therapy for acute myeloid leukemia
- Metformin reduces tumor burden and splenomegaly in JAK2V617F murine models
- Stathmin 1 is highly expressed in acute promyelocytic leukemia and microtubule dynamics is a potential target for ATRA-resistant APL cells
Informações sobre o DOI: 10.1038/s41392-019-0102-5 (Fonte: oaDOI API)
Download do texto completo
| Tipo | Nome | Link | |
|---|---|---|---|
 |
NT157 has antineoplastic ... | Direct link |
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
