Development of a novel nano-biomaterial for biomedical applications (2018)
- Authors:
- Machado, Vagner de Oliveira
- Santos, Cláudio Teodoro dos
- Motta, Adriana Cristina
- Duek, Eliana Aparecida de Rezende
- Silva, Messias Borges
- Gomes, Alaelson Vieira
- Cabral, Lucio M
- Carmo, Flávia Almada
- Elias, Carlos Nelson
- Andrade, Ângela Leão
- Simon, Alice
- Fernandéz, Daniel Ernesto Rodríguez
- Fabris, Jose Domingos
- Domingues, Rosana Zacarias
- Silva, Raphael Ferreira
- Silva, Thamiris Caroline Esteves
- Peixoto, Thainá Lopes
- Autor USP: SILVA, MESSIAS BORGES - EEL
- Unidade: EEL
- Sigla do Departamento: LOQ
- DOI: 10.1088/2053-1591/aae11b
- Assunto: NANOPARTÍCULAS
- Keywords: nanoprecipitation; nanoparticle; PLDLA-co-TMC; PEO-PPO-PEO; box-behnken; finasteride
- Agências de fomento:
- Language: Inglês
- Abstract: The technological development of biodegradable nanoparticlesfor drug delivery in medical diagnostics and therapies is addressing increasing efforts to make safer, affordable and more bio-efficient polymeric materials. The preparation via the solvent displacement method of a novel polymeric nanomaterial with new spherical and narrow sizes dispersion is described. It was achieved by choosing the best amount of PLDLA-co-TMC, PEO-PPO-PEO and an adequate acetone:methanol volume ratio, using thefactorial design 23 and Box-Behnken experiment design. This new material was loaded with finasteride, the chosen drug model, and its delivery dynamic was determined by the HPLC method. Results revealed that an optimal formulation of PLDLA-co-TMC nanoparticles was found to be composed of 20 mg PLDLA-co-TMC; 37.5 mg PEO-PPO-PEO and a volume acetone:methanol ratio 2.2:0.3. The formulation of this novel biomaterial showed a high encapsulation efficiency of finasteride, controlled release profile along 24 h, without burst effect in the first 4 h, nanometric sizes, spherical shapes, close polydispersity, negative surface charge, unimodal particle size distribution and relatively high thermal stability of the polymer matrix PEO-PPO-PEO/PLDLA-co-TMC. These results support thefabrication of technologically advanced nanoparticles based on high molecular weight PLDLA-co-TMC and their use in the nano-controlled drug release in biomedical applications.
- Imprenta:
- Publisher: IOP Science
- Publisher place: Kansas
- Date published: 2018
- Source:
- Título: Materials Research Express
- ISSN: 2053-1591
- Volume/Número/Paginação/Ano: v. 5, n. 12, p. 1-18, 2018
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
-
ABNT
MACHADO, Vagner de Oliveira et al. Development of a novel nano-biomaterial for biomedical applications. Materials Research Express, v. 5, n. 12, p. 1-18, 2018Tradução . . Disponível em: https://doi.org/10.1088/2053-1591/aae11b. Acesso em: 25 jan. 2026. -
APA
Machado, V. de O., Santos, C. T. dos, Motta, A. C., Duek, E. A. de R., Silva, M. B., Gomes, A. V., et al. (2018). Development of a novel nano-biomaterial for biomedical applications. Materials Research Express, 5( 12), 1-18. doi:10.1088/2053-1591/aae11b -
NLM
Machado V de O, Santos CT dos, Motta AC, Duek EA de R, Silva MB, Gomes AV, Cabral LM, Carmo FA, Elias CN, Andrade ÂL, Simon A, Fernandéz DER, Fabris JD, Domingues RZ, Silva RF, Silva TCE, Peixoto TL. Development of a novel nano-biomaterial for biomedical applications [Internet]. Materials Research Express. 2018 ; 5( 12): 1-18.[citado 2026 jan. 25 ] Available from: https://doi.org/10.1088/2053-1591/aae11b -
Vancouver
Machado V de O, Santos CT dos, Motta AC, Duek EA de R, Silva MB, Gomes AV, Cabral LM, Carmo FA, Elias CN, Andrade ÂL, Simon A, Fernandéz DER, Fabris JD, Domingues RZ, Silva RF, Silva TCE, Peixoto TL. Development of a novel nano-biomaterial for biomedical applications [Internet]. Materials Research Express. 2018 ; 5( 12): 1-18.[citado 2026 jan. 25 ] Available from: https://doi.org/10.1088/2053-1591/aae11b - Comparison of Different Types of Active Learning in a Course of Industrial Engineering
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Informações sobre o DOI: 10.1088/2053-1591/aae11b (Fonte: oaDOI API)
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