Correlations of the glycemic variability with oxidative stress and erythrocytes membrane stability in patients with type 1 diabetes under intensive treatment (2018)
- Authors:
- Autor USP: BERNARDINO NETO, MORUN - EEL
- Unidade: EEL
- DOI: 10.1016/j.diabres.2018.01.031
- Subjects: DIABETES MELLITUS; GLICEMIA; ERITRÓCITOS
- Keywords: Type 1 diabetes; Glycemic variability; Erythrocytes; Membrane stability; Oxidative stress
- Language: Inglês
- Abstract: Objectives This study aimed to evaluate the correlations of glycemic variability with erythrocyte membrane stability parameters and oxidative stress markers in patients with type 1 diabetes mellitus (T1DM) under intensive treatment. Material and methods 90 patients with T1DM and under intensive treatment of the disease were evaluated in relation to anthropometric indices, records of glycemic averages and parameters of glycemic variability, biochemical dosages (glucose, uric acid, lipidogram, glycated hemoglobin, microalbuminuria, creatinine and iron) reticulocyte count, erythrocyte membrane stability parameters and oxidative stress markers (thiobarbituric acid reactive substances, TBARS, and glutathione reductase, GR). Results Indicators of glycemic variability in the short and long term showed correlations with parameters of membrane stability and markers of oxidative stress (GR). In addition, the comparison of these same parameters between the subgroups consisting of quartiles of GV or glycemic control also showed significant differences. Conclusion In the T1DM patients studied here, glycemic variability showed correlations with oxidative stress and erythrocyte membrane stability variables. This corroborates the hypothesis that glycemic fluctuations interfere with lipid peroxidation and cell membrane behavior, emphasizing its participation in mechanisms related to the development of chronic complications of diabetes.
- Imprenta:
- Source:
- Título: Diabetes research and clinical practice
- ISSN: 0168-8227
- Volume/Número/Paginação/Ano: v.144, p. 31610-31618, 2018
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
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ABNT
RODRIGUES, Ricardo et al. Correlations of the glycemic variability with oxidative stress and erythrocytes membrane stability in patients with type 1 diabetes under intensive treatment. Diabetes research and clinical practice, v. 144, p. 31610-31618, 2018Tradução . . Disponível em: https://doi.org/10.1016/j.diabres.2018.01.031. Acesso em: 09 jan. 2026. -
APA
Rodrigues, R., Medeiros, L. A., Cunha, L. M., Garrote-Filho, M. da S., Bernardino Neto, M., Jorge, P. T., et al. (2018). Correlations of the glycemic variability with oxidative stress and erythrocytes membrane stability in patients with type 1 diabetes under intensive treatment. Diabetes research and clinical practice, 144, 31610-31618. doi:10.1016/j.diabres.2018.01.031 -
NLM
Rodrigues R, Medeiros LA, Cunha LM, Garrote-Filho M da S, Bernardino Neto M, Jorge PT, Resende ES, Silva NP. Correlations of the glycemic variability with oxidative stress and erythrocytes membrane stability in patients with type 1 diabetes under intensive treatment [Internet]. Diabetes research and clinical practice. 2018 ;144 31610-31618.[citado 2026 jan. 09 ] Available from: https://doi.org/10.1016/j.diabres.2018.01.031 -
Vancouver
Rodrigues R, Medeiros LA, Cunha LM, Garrote-Filho M da S, Bernardino Neto M, Jorge PT, Resende ES, Silva NP. Correlations of the glycemic variability with oxidative stress and erythrocytes membrane stability in patients with type 1 diabetes under intensive treatment [Internet]. Diabetes research and clinical practice. 2018 ;144 31610-31618.[citado 2026 jan. 09 ] Available from: https://doi.org/10.1016/j.diabres.2018.01.031 - Effects of acute and chronic exercise on the osmotic stability of erythrocyte membrane of competitive swimmers
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Informações sobre o DOI: 10.1016/j.diabres.2018.01.031 (Fonte: oaDOI API)
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