The elusive Luminal B breast cancer and the mysterious chemokines (2023)
- Authors:
- Araujo, Rogerio Agenor de
- Silva, Ana Cristina Araújo Lemos da
- Monteiro, Maria Luíza Gonçalves dos Reis
- Bernardino Neto, Morun
- Silva, Marcelo José Barbosa
- Luz, Felipe Andrés Cordero da
- Marinho, Eduarda da Costa
- Nascimento, Camila Piqui
- Mendes, Thais Rezende
- Mosca, Etelvina Rocha Tolentino
- Marques, Lara de Andrade
- Delfino, Patrícia Ferreira Ribeiro
- Antonioli, Rafael Mathias
- Araujo, Rogerio Agenor de
- Autor USP: BERNARDINO NETO, MORUN - EEL
- Unidade: EEL
- DOI: 10.1007/s00432-023-05094-2
- Subjects: IMUNOHISTOQUÍMICA; NEOPLASIAS; NEOPLASIAS MAMÁRIAS
- Keywords: Câncer de Mamas; Breast cancer; Chemokines; Luminal B; Staging; Immunohistochemistry
- Language: Inglês
- Abstract: Purpose Invasive ductal breast cancer (IDC) is heterogeneous. Staging and immunohistochemistry (IH) allow for effective therapy but are not yet ideal. Women with Luminal B tumors show an erratic response to treatment. This prospective study with 81 women with breast cancer aims to improve the prognostic stratification of Luminal B patients. Methods This is a prospective translational study with 81 women with infiltrating ductal carcinoma, grouped by TNM staging and immunohistochemistry, for survival analysis, and their correlations with the chemokines. Serum measurements of 13 chemokines were performed, including 7 CC chemokines [CCL2(MCP1), CCL3(MIP1α), CCL4(MIP1β), CCL5(Rantes), CCL11(Eotaxin), CCL17(TARC), CCL20(MIP3α)], 6 CXC chemokines [CXCL1(GroAlpha), CXCL5(ENA78), CCXCL8(IL-8), CXCL9(MIG), CXCL10(IP10), CXCL11(ITAC)]. Results Overall survival was significantly dependent on tumor staging and subtypes by immunohistochemistry, with a median follow-up time the 32.87 months (3.67–65.63 months). There were age correlations with IP10/CXCL10 chemokines (r = 0.4360; p = 0.0079) and TARC/CCL17 (Spearman + 0.2648; p = 0.0360). An inverse correlation was found between body weight and the chemokines Rantes/CCL5 (r = − 0.3098; p = 0.0169) and Eotaxin/CCL11 (r = − 0.2575; p = 0.0470). Smokers had a higher concentration of MIP3α/CCL20 (Spearman + 0.3344; p = 0.0267). Luminal B subtype patients who expressed lower concentrations of ENA78/CXCL5 (≤ 254.83 pg/ml) (Log-Rank p = 0.016) and higher expression of MIP1β/CCL4 (> 34.84 pg/ml) (Log-Rank p = 0.014) had a higher risk of metastases.
- Imprenta:
- Publisher: Springer Link
- Publisher place: Berlin
- Date published: 2023
- Source:
- Título: Journal of cancer research and clinical oncology
- ISSN: 01715216
- Volume/Número/Paginação/Ano: v.149, p.12807-12819, 2023
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
ARAUJO, Rogerio Agenor de et al. The elusive Luminal B breast cancer and the mysterious chemokines. Journal of cancer research and clinical oncology, v. 149, p. 12807-12819, 2023Tradução . . Disponível em: https://doi.org/10.1007/s00432-023-05094-2. Acesso em: 01 out. 2024. -
APA
Araujo, R. A. de, Silva, A. C. A. L. da, Monteiro, M. L. G. dos R., Bernardino Neto, M., Silva, M. J. B., Luz, F. A. C. da, et al. (2023). The elusive Luminal B breast cancer and the mysterious chemokines. Journal of cancer research and clinical oncology, 149, 12807-12819. doi:10.1007/s00432-023-05094-2 -
NLM
Araujo RA de, Silva ACAL da, Monteiro MLG dos R, Bernardino Neto M, Silva MJB, Luz FAC da, Marinho E da C, Nascimento CP, Mendes TR, Mosca ERT, Marques L de A, Delfino PFR, Antonioli RM. The elusive Luminal B breast cancer and the mysterious chemokines [Internet]. Journal of cancer research and clinical oncology. 2023 ;149 12807-12819.[citado 2024 out. 01 ] Available from: https://doi.org/10.1007/s00432-023-05094-2 -
Vancouver
Araujo RA de, Silva ACAL da, Monteiro MLG dos R, Bernardino Neto M, Silva MJB, Luz FAC da, Marinho E da C, Nascimento CP, Mendes TR, Mosca ERT, Marques L de A, Delfino PFR, Antonioli RM. The elusive Luminal B breast cancer and the mysterious chemokines [Internet]. Journal of cancer research and clinical oncology. 2023 ;149 12807-12819.[citado 2024 out. 01 ] Available from: https://doi.org/10.1007/s00432-023-05094-2 - Saúde Mental, Uso de Álcool e Qualidade do Sono em Estudantes de uma Universidade Pública
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Informações sobre o DOI: 10.1007/s00432-023-05094-2 (Fonte: oaDOI API)
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