Artigo de periodico

Oropharyngeal Colostrum Administration and Anti-inflammatory Effects in Very Low Birth Weight Preterm Neonates (2021)

• Authors:
  • Martins, Maria Carolina de
  • Bernardino Neto, Morun
  • Goulart, Luiz Ricardo
  • Abdallah, Vânia OS
  • Ferreira, Daniela M. L. M
  • Maia, Larissa Prado
  • Alves, Patrícia Terra
  • Paula, Aline Teodoro de
  • Santiago, Fernanda Maria
  • Mineo, José Roberto
  • Sopelete, Mônica C.
  • Martinez, Francisco Eduardo
• Autor USP: BERNARDINO NETO, MORUN - EEL
• Unidade: EEL
• DOI: 10.31080/ASPE.2021.04.0479
• Subjects: COLOSTRO; IMUNOTERAPIA; BEBÊ PREMATURO
• Keywords: Colostrum; Oropharyngeal Administration; Immune Therapy; Neonatal Sepsis; Premature Infant; Biomarkers
• Agências de fomento:
  • Financiamento CNPq
  • Financiamento FAPEMIG
  • Financiamento CAPES
• Language: Inglês
• Abstract: Objective: Infections are the main causes of morbidity and mortality in very low birth weight preterm neonates (VLBW PTN) leading to systemic inflammatory imbalance. The oropharyngeal administration of own mother’s milk, particularly colostrum, has been suggested as an immunostimulatory action for protection against neonatal sepsis. As urine has been poorly evaluated in both systemic inflammation and neonatal sepsis, our purpose was to evaluate the effect of oropharyngeal administration of colostrum on the secretion of proinflammatory and anti-inflammatory cytokines in the urine of VLBW PTN. Methods: From a randomized, double blinded, placebo-controlled trial, urine samples were randomly selected from 55 preterm infants, of which 29 underwent oropharyngeal administration of own mother’s colostrum and 26 received distilled water. Urine samples were collected before and 24 hours after the end of the oropharyngeal administration and analyzed using the Milliplex-27 kit on the MagPix (Luminex) equipment. Results: A significant reduction in proinflammatory cytokines like IFN - γ (p = 0.005), TNF - α (p = 0.002), IL - 8 (p = 0.012), IL - 9 (p = 0.011), IL -15 (p = 0.012), IL - 17a (p = 0.001) and RANTES (p = 0.018) was observed in the group of children undergoing oropharyngeal administration of colostrum. However, there was no statistically significant difference in the incidence of clinical (OR 1.023; CI 95% 0.344-3.040) and confirmed sepsis (OR 1.158; CI 95% 0.344-3.899) in very low birth weight preterm neonates undergoing oropharyngeal administration of colostrum when compared to the group receiving distilled water. Conclusion: The oropharyngeal administration of colostrum promoted an anti-inflammatory state, characterized by the reduction of proinflammatory cytokines, which may contribute to the reduction of the incidence of neonatal sepsis.
• Source:
  • Título: Acta Scientific Paediatrics
  • ISSN: 2581-883X
  • Volume/Número/Paginação/Ano: v.4, n.12, p.39-47, 2021

Informações sobre o DOI: 10.31080/ASPE.2021.04.0479 (Fonte: oaDOI API)
• Este periódico é de acesso aberto
• Este artigo NÃO é de acesso aberto
  

---

How to cite

A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

• ABNT

  MARTINS, Maria Carolina de et al. Oropharyngeal Colostrum Administration and Anti-inflammatory Effects in Very Low Birth Weight Preterm Neonates. Acta Scientific Paediatrics, v. 4, n. 12, p. 39-47, 2021Tradução . . Disponível em: https://doi.org/10.31080/ASPE.2021.04.0479. Acesso em: 28 fev. 2026.

• APA

  Martins, M. C. de, Bernardino Neto, M., Goulart, L. R., Abdallah, V. O. S., Ferreira, D. M. L. M., Maia, L. P., et al. (2021). Oropharyngeal Colostrum Administration and Anti-inflammatory Effects in Very Low Birth Weight Preterm Neonates. Acta Scientific Paediatrics, 4( 12), 39-47. doi:10.31080/ASPE.2021.04.0479

• NLM

  Martins MC de, Bernardino Neto M, Goulart LR, Abdallah VOS, Ferreira DMLM, Maia LP, Alves PT, Paula AT de, Santiago FM, Mineo JR, Sopelete MC, Martinez FE. Oropharyngeal Colostrum Administration and Anti-inflammatory Effects in Very Low Birth Weight Preterm Neonates [Internet]. Acta Scientific Paediatrics. 2021 ;4( 12): 39-47.[citado 2026 fev. 28 ] Available from: https://doi.org/10.31080/ASPE.2021.04.0479

• Vancouver

  Martins MC de, Bernardino Neto M, Goulart LR, Abdallah VOS, Ferreira DMLM, Maia LP, Alves PT, Paula AT de, Santiago FM, Mineo JR, Sopelete MC, Martinez FE. Oropharyngeal Colostrum Administration and Anti-inflammatory Effects in Very Low Birth Weight Preterm Neonates [Internet]. Acta Scientific Paediatrics. 2021 ;4( 12): 39-47.[citado 2026 fev. 28 ] Available from: https://doi.org/10.31080/ASPE.2021.04.0479

Últimas obras dos mesmos autores vinculados com a USP cadastradas na BDPI:

• EGF (epidermal growth factor) receptor expression in blood: Prognostic biomarker in overall survival (OS) of patients with non-metastatic triple negative (TN) breast carcinoma.
• Epidermal growth factor receptor (EGFR) expression in the serum of patients with triple-negative breast carcinoma: prognostic value of this biomarker
• Influence of erythrocyte membrane stability in atherosclerosis
• Swimming reduces fatty acids-associated hypothalamic damage in mice
• The elusive Luminal B breast cancer and the mysterious chemokines
• Correlations of the glycemic variability with oxidative stress and erythrocytes membrane stability in patients with type 1 diabetes under intensive treatment
• How effective is the use of glycemic variability in the follow-up of type 1 diabetes under intensive care?
• Expression of epidermal growth factor receptor (EGFR) in blood and tumor in patients with breast carcinoma: Prognostic analysis.
• Aging profile, adherence to the Elderly Health Handbook and health self-perception, Ituiutaba-MG (2015 and 2018)
• Saúde Mental, Uso de Álcool e Qualidade do Sono em Estudantes de uma Universidade Pública