Fragment screening reveals novel scaffolds against sirtuin-2-related Protein 1 from Trypanosoma brucei (2025)
- Authors:
- USP affiliated authors: MARANA, SANDRO ROBERTO - IQ ; EMERY, FLAVIO DA SILVA - FCFRP ; TROSSINI, GUSTAVO HENRIQUE GOULART - FCF ; GODOI, BRUNA FLECK - FCFRP
- Unidades: IQ; FCFRP; FCF
- DOI: 10.1021/acsomega.4c09231
- Subjects: TRYPANOSOMA; LIGANTES; PEPTÍDEOS; PROTEÍNAS
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher place: Washington
- Date published: 2025
- Source:
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
-
ABNT
GOMES, Renan Augusto et al. Fragment screening reveals novel scaffolds against sirtuin-2-related Protein 1 from Trypanosoma brucei. ACS Omega, v. 10, n. 4, p. 3808–3819, 2025Tradução . . Disponível em: https://dx.doi.org/10.1021/acsomega.4c09231. Acesso em: 10 fev. 2026. -
APA
Gomes, R. A., Polêto, M. D., Verli, H., Almeida, V. M., Marana, S. R., Bender, A., et al. (2025). Fragment screening reveals novel scaffolds against sirtuin-2-related Protein 1 from Trypanosoma brucei. ACS Omega, 10( 4), 3808–3819. doi:10.1021/acsomega.4c09231 -
NLM
Gomes RA, Polêto MD, Verli H, Almeida VM, Marana SR, Bender A, Godoi BF, Rodrigues VTL, Emery F da S, Trossini GHG. Fragment screening reveals novel scaffolds against sirtuin-2-related Protein 1 from Trypanosoma brucei [Internet]. ACS Omega. 2025 ; 10( 4): 3808–3819.[citado 2026 fev. 10 ] Available from: https://dx.doi.org/10.1021/acsomega.4c09231 -
Vancouver
Gomes RA, Polêto MD, Verli H, Almeida VM, Marana SR, Bender A, Godoi BF, Rodrigues VTL, Emery F da S, Trossini GHG. Fragment screening reveals novel scaffolds against sirtuin-2-related Protein 1 from Trypanosoma brucei [Internet]. ACS Omega. 2025 ; 10( 4): 3808–3819.[citado 2026 fev. 10 ] Available from: https://dx.doi.org/10.1021/acsomega.4c09231 - Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry
- Synthesis and docking study for compounds analogs of LSD1 inhibitor
- Virtual screening applied in hit identification as LSD1 inhibitors, a epigenetic target for cancer treatment
- Construction and validation of the 3D-structure of T. Cruzi sirtuin-2 by modeling threading
- QSAR studies on the human sirtuin 2 inhibition by non-covalent 7,5,2-anilinobenzamide derivatives
- Hologram quantitative structure–activity relationship and comparative molecular interaction field analysis of aminothiazole and thiazolesulfonamide as reversible LSD1 inhibitors
- Trypanosoma cruzi Sirtuin 2 as a relevant druggable target: new inhibitors developed by computer-aided drug design
- Human sirtuin 2 inhibitors, their mechanisms and binding modes
- β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders
- Insights into newly approved drugs from a medicinal chemistry perspective
Informações sobre o DOI: 10.1021/acsomega.4c09231 (Fonte: oaDOI API)
Download do texto completo
| Tipo | Nome | Link | |
|---|---|---|---|
 |
3233758.pdf | Direct link |
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
