Artigo de periodico

Extracellular L-asparaginase production in solid-state fermentation by using sugarcane bagasse as support material (2019)

• Authors:
  • Cachumba, Jorge Javier Muso
  • Hilares, Ruly Terán
  • Santos, Julio Cesar dos
  • Brumano, Larissa Pereira
  • Marcelino, Paulo Ricardo Franco
  • Antunes, Felipe Antônio Fernandes
  • Silva, Silvio Silverio da
• USP affiliated authors: SILVA, SILVIO SILVERIO DA - EEL ; SANTOS, JÚLIO CÉSAR DOS - EEL ; CACHUMBA, JORGE JAVIER MUSO - FCF ; HILARES, RULY TERÁN - EEL ; BRUMANO, LARISSA PEREIRA - FCF ; MARCELINO, PAULO RICARDO FRANCO - EEL
• Unidades: EEL; FCF
• DOI: 10.1080/10826068.2019.1566152
• Assunto: BIOTECNOLOGIA
• Keywords: Columnbioreactor; Aspergillus terreus; L-asparaginase; Solid state fermentation; Sugarcane bagasse
• Agências de fomento:
  • Financiamento PEC-PG
  • Financiamento CNPq
  • Financiamento FAPESP
• Language: Inglês
• Abstract: L-asparaginase is an important enzyme used in the pharmaceutical and food industry, which can be produced by different microorganisms using low cost feedstocks. In this work, sugarcane bagasse (SCB) was used as support for enzyme production in solid-state fermentation (SSF) by A. terreus. Initially, the influence of the variables carbon and nitrogen sources on the enzyme production was studied following an experimental design carried out in Erlenmeyer flasks. Statistical analysis indicated the use of 0.54% of starch, 0% of maltose, 0.44% of asparagine, and 1.14% of glutamine in the medium, resulting in enzyme activity per volume of produced extract of 120.723 U/L. Then, these conditions were applied in a horizontal column reactor filled with SCB, producing 105.3 U/L of enzyme activity. Therefore, the potential of extracellular L-asparaginase enzyme production in the column reactor using sugarcane bagasse as support was demonstrated and it represents a system that can favor large scale production.
• Imprenta:
  • Publisher: Taylor & Francis
  • Publisher place: Delhi
  • Date published: 2019
• Source:
  • Título: Preparative biochemistry & biotechnology
  • ISSN: 1082-6068
  • Volume/Número/Paginação/Ano: v.49, n.4, p.1-6, 2019

Informações sobre o DOI: 10.1080/10826068.2019.1566152 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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How to cite

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• ABNT

  CACHUMBA, Jorge Javier Muso et al. Extracellular L-asparaginase production in solid-state fermentation by using sugarcane bagasse as support material. Preparative biochemistry & biotechnology, v. 49, n. 4, p. 1-6, 2019Tradução . . Disponível em: https://doi.org/10.1080/10826068.2019.1566152. Acesso em: 29 dez. 2025.

• APA

  Cachumba, J. J. M., Hilares, R. T., Santos, J. C. dos, Brumano, L. P., Marcelino, P. R. F., Antunes, F. A. F., & Silva, S. S. da. (2019). Extracellular L-asparaginase production in solid-state fermentation by using sugarcane bagasse as support material. Preparative biochemistry & biotechnology, 49( 4), 1-6. doi:10.1080/10826068.2019.1566152

• NLM

  Cachumba JJM, Hilares RT, Santos JC dos, Brumano LP, Marcelino PRF, Antunes FAF, Silva SS da. Extracellular L-asparaginase production in solid-state fermentation by using sugarcane bagasse as support material [Internet]. Preparative biochemistry & biotechnology. 2019 ;49( 4): 1-6.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1080/10826068.2019.1566152

• Vancouver

  Cachumba JJM, Hilares RT, Santos JC dos, Brumano LP, Marcelino PRF, Antunes FAF, Silva SS da. Extracellular L-asparaginase production in solid-state fermentation by using sugarcane bagasse as support material [Internet]. Preparative biochemistry & biotechnology. 2019 ;49( 4): 1-6.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1080/10826068.2019.1566152

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