Selection and Control of Process Conditions Enable the Preparation of Curcumin-Loaded Poly(lactic-co-glycolic acid) Nanoparticles of Superior Performance (2023)
- Authors:
- Autor USP: LOPES, ANDRÉ MORENI - EEL
- Unidade: EEL
- DOI: 10.1021/acsami.3c05560
- Subjects: NANOPARTÍCULAS; BIOMATERIAIS
- Keywords: curcumin (CUR); nanoparticles (NPs); biomaterial; controlled release; process optimization; drug delivery systems (DDS)
- Agências de fomento:
- Language: Inglês
- Abstract: Curcumin(CUR) is one natural bioactive compound acknowledged for diverse therapeutic activities, but its use is hindered by its poor bioavailability, fast metabolism, and susceptibility to pH variations and light exposure.Thus, the encapsulation in poly (lactic-co-glycolicacid), or PLGA, has been successfully used to protectand enhance CUR absorptionin the organism, making CUR-loaded PLGA nanoparticles (NPs) promising drug delivery systems. However,few studies have focused beyond CUR bioavailability, on the environmental variables involved in the encapsulation process, and whether they could help obtain NPs of superior performance. Our stud yevaluated pH (3.0 or 7.0), temperature (15 or 35°C), light exposure, and inert atmosphere (N2) incidence in the encapsulation of CUR. The best outcome was at pH 3.0, 15°C, without light incidence,and without N2 usage. This best nanoformulation showed NP size, zeta potential, and encapsulation efficiency (EE) of 297 nm,−21 mV, and 72%, respectively. Moreover, the CUR in vitro release at pH values 5.5 and 7.4 suggested different potential applications for these NPs, one of which was demonstratedby the effective inhibition of multiplebacteria (i.e., Gram-negative, Gram-positive, and multi-resistant) in the minimal inhibition concentration assay. Besides, statistical analyses confirmed a significant impact of temperature on the NP size; in addition, temperature, light, and N2 affected the EE of CUR. Thus, the selectionand controlof process variables resulted in higher CUR encapsulation and customizable outcomes, ultimately enablingmore economical processes and providing future scale-up guidelines.
- Imprenta:
- Publisher: ACS
- Publisher place: Washington, DC
- Date published: 2023
- Source:
- Título: Acs applied materials & interfaces (online)
- ISSN: 1944-8252
- Volume/Número/Paginação/Ano: v.15, n.22, p.26496–26509, 2023
- Status:
- Nenhuma versão em acesso aberto identificada
-
ABNT
FELTRIN, Felipe da Silva et al. Selection and Control of Process Conditions Enable the Preparation of Curcumin-Loaded Poly(lactic-co-glycolic acid) Nanoparticles of Superior Performance. Acs applied materials & interfaces (online), v. 15, n. 22, p. 26496–26509, 2023Tradução . . Disponível em: https://doi.org/10.1021/acsami.3c05560. Acesso em: 09 abr. 2026. -
APA
Feltrin, F. da S., D'Angelo, N. A., Guarnieri, J. P. de O., Lopes, A. M., Lancellotti, M., & Lona, L. M. F. (2023). Selection and Control of Process Conditions Enable the Preparation of Curcumin-Loaded Poly(lactic-co-glycolic acid) Nanoparticles of Superior Performance. Acs applied materials & interfaces (online), 15( 22), 26496–26509. doi:10.1021/acsami.3c05560 -
NLM
Feltrin F da S, D'Angelo NA, Guarnieri JP de O, Lopes AM, Lancellotti M, Lona LMF. Selection and Control of Process Conditions Enable the Preparation of Curcumin-Loaded Poly(lactic-co-glycolic acid) Nanoparticles of Superior Performance [Internet]. Acs applied materials & interfaces (online). 2023 ;15( 22): 26496–26509.[citado 2026 abr. 09 ] Available from: https://doi.org/10.1021/acsami.3c05560 -
Vancouver
Feltrin F da S, D'Angelo NA, Guarnieri JP de O, Lopes AM, Lancellotti M, Lona LMF. Selection and Control of Process Conditions Enable the Preparation of Curcumin-Loaded Poly(lactic-co-glycolic acid) Nanoparticles of Superior Performance [Internet]. Acs applied materials & interfaces (online). 2023 ;15( 22): 26496–26509.[citado 2026 abr. 09 ] Available from: https://doi.org/10.1021/acsami.3c05560 - Influence of Choline Chloride on the Phase Equilibria and Partition Performance of Polymer/Polymer Aqueous Biphasic Systems
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