Artigo de periodico

Comprehensive review on biotechnological production of hyaluronic acid: status, innovation, market and applications (2022)

• Authors:
  • Ruschoni, Uirajá Cayowa Magalhães
  • Mera, Alain Eduard Monsalve
  • Zamudio, Luz Haydee Bravo
  • Kumar, Vinod
  • Taherzadeh, Mohammad J.
  • Garlapati, Vijay Kumar
  • Chandel, Anuj Kumar
• USP affiliated authors: KUMAR, ANUJ - EEL ; MERA, ALAIN EDUARD MONSALVE - EEL ; ZAMUDIO, LUZ HAYDEE BRAVO - EEL ; RUSCHONI, UIRAJÁ CAYOWA MAGALHÃES - EEL
• Unidade: EEL
• DOI: 10.1080/21655979.2022.2057760
• Subjects: BIOTECNOLOGIA; FERMENTAÇÃO
• Keywords: Hyaluronic acid; industrial scenario; streptococcus zooepidemicus; fermentation; downstream processing
• Language: Inglês
• Abstract: The growing, existing demand for low-cost and high-quality hyaluronic acid (HA) needs an outlook of different possible production strategies from renewable resources with the reduced possibility of cross-infections. Recently, the possibility of producing HA from harmless microorganisms appeared, which offers the opportunity to make HA more economical, without raw material limitations, and environmentally friendly. HA production is mainly reported with Lancefield Streptococci A and C, particularly from S. equi and S. zooepidemicus. Various modes of fermentation such as batch, repeated batch, fed-batch, and continuous culture have been investigated to optimize HA production, particularly from S. zooepidemicus, obtaining a HA yield of 2.5 g L−1 – 7.0 g L−1. Among the different utilized DSP approaches of HA production, recovery with cold ethanol (4°C) and cetylpyridinium chloride is the ideal strategy for lab-scale HA production. On the industrial scale, besides using isopropanol, filtration (0.22 um), ultrafiltration (100 kDa), and activated carbon absorption are employed to obtain HA of low molecular weight and additional ultrafiltration to purify HA of higher MW. Even though mature technologies have already been developed for the industrial production of HA, the projections of increased sales volume and the expansion of application possibilities require new processes to obtain HA with higher productivity, purity, and specific molecular weights. In this review, we have put forth the progress of HA technological research by discussing the microbial biosynthetic aspects, fermentation and downstream strategies, industrial-scale scenarios of HA, and the prospects of HA production to meet the current and ongoing market demands.
• Imprenta:
  • Publisher place: Londres
  • Date published: 2022
• Source:
  • Título: Bioengineered
  • ISSN: 21655979
  • Volume/Número/Paginação/Ano: v.13, n.4, p.9645-9661, 2022

Informações sobre a disponibilidade de versões do artigo em acesso aberto coletadas automaticamente via oaDOI API (Unpaywall).
• Este artigo possui versão em acesso aberto
• URL de acesso aberto
• PDF de acesso aberto
• Versão do Documento: Versão publicada (Published version)
• Status: Artigo publicado em periódico de acesso aberto (Gold Open Access)

---

How to cite

A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

• ABNT

  RUSCHONI, Uirajá Cayowa Magalhães et al. Comprehensive review on biotechnological production of hyaluronic acid: status, innovation, market and applications. Bioengineered, v. 13, n. 4, p. 9645-9661, 2022Tradução . . Disponível em: https://doi.org/10.1080/21655979.2022.2057760. Acesso em: 14 mar. 2026.

• APA

  Ruschoni, U. C. M., Mera, A. E. M., Zamudio, L. H. B., Kumar, V., Taherzadeh, M. J., Garlapati, V. K., & Chandel, A. K. (2022). Comprehensive review on biotechnological production of hyaluronic acid: status, innovation, market and applications. Bioengineered, 13( 4), 9645-9661. doi:10.1080/21655979.2022.2057760

• NLM

  Ruschoni UCM, Mera AEM, Zamudio LHB, Kumar V, Taherzadeh MJ, Garlapati VK, Chandel AK. Comprehensive review on biotechnological production of hyaluronic acid: status, innovation, market and applications [Internet]. Bioengineered. 2022 ;13( 4): 9645-9661.[citado 2026 mar. 14 ] Available from: https://doi.org/10.1080/21655979.2022.2057760

• Vancouver

  Ruschoni UCM, Mera AEM, Zamudio LHB, Kumar V, Taherzadeh MJ, Garlapati VK, Chandel AK. Comprehensive review on biotechnological production of hyaluronic acid: status, innovation, market and applications [Internet]. Bioengineered. 2022 ;13( 4): 9645-9661.[citado 2026 mar. 14 ] Available from: https://doi.org/10.1080/21655979.2022.2057760

Últimas obras dos mesmos autores vinculados com a USP cadastradas na BDPI:

• Lignin Conversion though Biological and Chemical Routes and Potential Chemicals
• Structural and enzymatic features of a recombinant &beta;-fructofuranosidase from <i>Bifidobacterium adolescentis</i>
• Effect of Biosurfactants and non-catalytic proteins on the enzymatic hydrolysis of cellulignin
• Circular economy aspects of lignin: Towards a lignocellulose biorefinery
• Coronavirus disease 2019
• Bioengineering to Accelerate Biodiesel Production for a Sustainable Biorefinery
• Integrated Fermentative Production and Downstream Processing of 2,3-Butanediol from Sugarcane Bagasse-Derived Xylose by Mutant Strain of
• Pernicious parthenium weed: an insight into its biogenic control and transformation to organic fertilizer
• Lignocellulose derived functional oligosaccharides: production, properties, and health benefits
• Sustainable Biotechnology- Enzymatic resources of Renewable Energy