Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs (2019)
- Authors:
- USP affiliated authors: SAMPAIO, SIMONE DE FÁTIMA MEDEIROS - EEL ; SANTOS, AMILTON MARTINS DOS - EEL ; FORNI, ABILIO AUGUSTO JOSÉ - EEL
- Unidade: EEL
- DOI: 10.1002/app.48472
- Subjects: NANOTECNOLOGIA; POLÍMEROS (QUÍMICA ORGÂNICA)
- Agências de fomento:
- Language: Inglês
- Abstract: In this work, nanofiber scaffolds for surface drug delivery applications were obtained by electrospinning poly(N-vinylcaprolactam) (PNVCL) and its blends with poly(ε-caprolactone) and poly(N-vinylcaprolactam)-b-poly(ε-caprolactone). The process parameters to obtain smooth and beadless PNVCL fibers were optimized. The average fibers diameter was less than 1 μm, and it was determined by scanning electron microscopy analyses. Their affinity toward water was evaluated by measuring the contact angle with water. The ketoprofen release behavior from the fibers was analyzed using independent and model-dependent approaches. The low values of the release exponent (n < 0.5) obtained for 20 and 42 °C, indicating a Fickian diffusion mechanism for all formulations. Dissolution efficiencies (DEs) revealed the effect of polymer composition, methodology used in the electrospinning process, and temperature on the release rate of ketoprofen. PNVCL/poly(N-vinylcaprolactam)-b-poly(ε-caprolactone)-based nanofibers showed greater ability to control the in vitro release of ketoprofen, in view of reduced kinetic constant and DE, making this material promising system for controlling release of hydrophobic drugs.
- Imprenta:
- Source:
- Título: Journal of applied polymer science (online)
- ISSN: 10974628
- Volume/Número/Paginação/Ano: v.137, n.11, p.1-14, 2019
- Este artigo NÃO possui versão em acesso aberto
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Status: Nenhuma versão em acesso aberto identificada -
ABNT
STA, Marwa et al. Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs. Journal of applied polymer science (online), v. 137, n. 11, p. 1-14, 2019Tradução . . Disponível em: https://doi.org/10.1002/app.48472. Acesso em: 17 mar. 2026. -
APA
Sta, M., Aguiar, G. A. J., Forni, A. J. A., Medeiros, S. de F., Santos, A. M. dos, & Demarquette, N. R. (2019). Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs. Journal of applied polymer science (online), 137( 11), 1-14. doi:10.1002/app.48472 -
NLM
Sta M, Aguiar GAJ, Forni AJA, Medeiros S de F, Santos AM dos, Demarquette NR. Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs [Internet]. Journal of applied polymer science (online). 2019 ;137( 11): 1-14.[citado 2026 mar. 17 ] Available from: https://doi.org/10.1002/app.48472 -
Vancouver
Sta M, Aguiar GAJ, Forni AJA, Medeiros S de F, Santos AM dos, Demarquette NR. Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs [Internet]. Journal of applied polymer science (online). 2019 ;137( 11): 1-14.[citado 2026 mar. 17 ] Available from: https://doi.org/10.1002/app.48472 - Electrospun poly(NVCL-co-AA) fibers as potential thermo-and pH-sensitive agents for controlled release of hydrophobic drugs
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