Artigo de periodico

Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs (2019)

• Authors:
  • Sta, Marwa
  • Aguiar, Graziele A. J.
  • Forni, Abilio J. A.
  • Medeiros, Simone de Fátima
  • Santos, Amilton Martins dos
  • Demarquette, Nicole Raymonde
• USP affiliated authors: SAMPAIO, SIMONE DE FÁTIMA MEDEIROS - EEL ; SANTOS, AMILTON MARTINS DOS - EEL ; FORNI, ABILIO AUGUSTO JOSÉ - EEL
• Unidade: EEL
• DOI: 10.1002/app.48472
• Subjects: NANOTECNOLOGIA; POLÍMEROS (QUÍMICA ORGÂNICA)
• Agências de fomento:
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
• Language: Inglês
• Abstract: In this work, nanofiber scaffolds for surface drug delivery applications were obtained by electrospinning poly(N-vinylcaprolactam) (PNVCL) and its blends with poly(ε-caprolactone) and poly(N-vinylcaprolactam)-b-poly(ε-caprolactone). The process parameters to obtain smooth and beadless PNVCL fibers were optimized. The average fibers diameter was less than 1 μm, and it was determined by scanning electron microscopy analyses. Their affinity toward water was evaluated by measuring the contact angle with water. The ketoprofen release behavior from the fibers was analyzed using independent and model-dependent approaches. The low values of the release exponent (n < 0.5) obtained for 20 and 42 °C, indicating a Fickian diffusion mechanism for all formulations. Dissolution efficiencies (DEs) revealed the effect of polymer composition, methodology used in the electrospinning process, and temperature on the release rate of ketoprofen. PNVCL/poly(N-vinylcaprolactam)-b-poly(ε-caprolactone)-based nanofibers showed greater ability to control the in vitro release of ketoprofen, in view of reduced kinetic constant and DE, making this material promising system for controlling release of hydrophobic drugs.
• Imprenta:
  • Publisher place: Quebec
  • Date published: 2019
• Source:
  • Título: Journal of applied polymer science (online)
  • ISSN: 10974628
  • Volume/Número/Paginação/Ano: v.137, n.11, p.1-14, 2019

Informações sobre o DOI: 10.1002/app.48472 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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• ABNT

  STA, Marwa et al. Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs. Journal of applied polymer science (online), v. 137, n. 11, p. 1-14, 2019Tradução . . Disponível em: https://doi.org/10.1002/app.48472. Acesso em: 30 dez. 2025.

• APA

  Sta, M., Aguiar, G. A. J., Forni, A. J. A., Medeiros, S. de F., Santos, A. M. dos, & Demarquette, N. R. (2019). Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs. Journal of applied polymer science (online), 137( 11), 1-14. doi:10.1002/app.48472

• NLM

  Sta M, Aguiar GAJ, Forni AJA, Medeiros S de F, Santos AM dos, Demarquette NR. Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs [Internet]. Journal of applied polymer science (online). 2019 ;137( 11): 1-14.[citado 2025 dez. 30 ] Available from: https://doi.org/10.1002/app.48472

• Vancouver

  Sta M, Aguiar GAJ, Forni AJA, Medeiros S de F, Santos AM dos, Demarquette NR. Design and characterization of PNVCL-based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs [Internet]. Journal of applied polymer science (online). 2019 ;137( 11): 1-14.[citado 2025 dez. 30 ] Available from: https://doi.org/10.1002/app.48472

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