Systemic low-grade inflammation associated lifestyle, diet, andgenetic factors: a population-based cross-sectional study (2020)
- Authors:
- USP affiliated authors: ROGERO, MARCELO MACEDO - FSP ; MARCHIONI, DIRCE MARIA LOBO - FSP ; FISBERG, REGINA MARA - FSP ; NORDE, MARINA MAINTINGUER - FSP
- Unidade: FSP
- DOI: 10.1016/j.nut.2019.110596
- Subjects: POLIMORFISMO; DOENÇA CRÔNICA; MODO DE VIDA; DIETA; ESTUDOS TRANSVERSAIS
- Agências de fomento:
- Language: Inglês
- Abstract: Objectives:Systemic low-grade inflammation (SLGI) is an intermediary common condition to the physiopa-thology of chronic noncommunicable diseases and targeting its determinants could lead to more efficientpublic health strategies. We aimed to investigate SLGI-independent associations with lifestyle, diet, andgenetic factors in a population-based sample of adults using a systemic low-grade inflammation score (SIS).Methods:The study sample is composed of 269 participants from the cross-sectional population-basedHealth Survey of Sao Paulo (2008-2010), ages 20 to 59 y, whose data on socioeconomic variables, lifestyle,health parameters, and blood samples were available. Diet was assessed by two 24-h recalls, and the Brazil-ian Health Eating Index-Revised (BHEI-R) was scored. From blood samples, 30 single nucleotide polymor-phisms on inflammatory genes were genotyped, and plasma eleven inflammatory biomarkers levels thatcomposed the SIS were determined. A multiple, stepwise, linear regression was used to investigate SIS-inde-pendent associated factors.Results:Factors independently associated with SIS were BHEI-R score (partial R2= 5.1;b= -0.13;P= 0.003),body mass index (partial R2= 3.4;b= 0.19;P= 0.001),TLR4rs5030728 GA + AA genotype (partial R2= 3.1;b= -1.37;P= 0.008), age 50 to 59 y (partial R2= 2.5;b= 1.93;P= 0.029) in comparison with the reference cat-egory (20 to 29 y), and commuting physical activity>150 min/wk (partial R2= 2.2;b= -1.29;P= 0.043) afteradjustment for current smoking status, medication use, and dietary misreporting.Conclusions:Eating a lower quality diet, having a higher body mass index score and age, being GG homozy-gous forTLR4rs5030728, and spending<150 min/wk in transportation physical activity are independentdeterminants of SLGI
- Imprenta:
- Source:
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ABNT
NORDE, Marina Maintinguer et al. Systemic low-grade inflammation associated lifestyle, diet, andgenetic factors: a population-based cross-sectional study. Nutrition, v. 70, p. [6], 2020Tradução . . Disponível em: https://doi.org/10.1016/j.nut.2019.110596. Acesso em: 13 fev. 2026. -
APA
Norde, M. M., Fisberg, R. M., Marchioni, D. M. L., & Rogero, M. M. (2020). Systemic low-grade inflammation associated lifestyle, diet, andgenetic factors: a population-based cross-sectional study. Nutrition, 70, [6]. doi:10.1016/j.nut.2019.110596 -
NLM
Norde MM, Fisberg RM, Marchioni DML, Rogero MM. Systemic low-grade inflammation associated lifestyle, diet, andgenetic factors: a population-based cross-sectional study [Internet]. Nutrition. 2020 ;70 [6].[citado 2026 fev. 13 ] Available from: https://doi.org/10.1016/j.nut.2019.110596 -
Vancouver
Norde MM, Fisberg RM, Marchioni DML, Rogero MM. Systemic low-grade inflammation associated lifestyle, diet, andgenetic factors: a population-based cross-sectional study [Internet]. Nutrition. 2020 ;70 [6].[citado 2026 fev. 13 ] Available from: https://doi.org/10.1016/j.nut.2019.110596 - Systemic low-grade inflammation-associated lifestyle, diet, and genetic factors: A population-based cross-sectional study
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Informações sobre o DOI: 10.1016/j.nut.2019.110596 (Fonte: oaDOI API)
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