Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil (2019)
- Authors:
- USP affiliated authors: FISBERG, REGINA MARA - FSP ; MARCHIONI, DIRCE MARIA LOBO - FSP ; ROGERO, MARCELO MACEDO - FSP ; FUJII, TATIANE MIEKO DE MENESES - FSP ; NORDE, MARINA MAINTINGUER - FSP
- Unidade: FSP
- DOI: 10.1177/0260106019830844
- Subjects: LIPÍDEOS; DOENÇAS CARDIOVASCULARES; METABOLISMO DE GORDURA; NUTRIGENÔMICA
- Agências de fomento:
- Language: Inglês
- Abstract: Background:Dyslipidemia can be influenced by genetic and dietary risk factors.Aim:This study set out to investigatediet and genetic variations in Brazilian people in a cross-sectional population-based survey and to analyze the relationshipbetween single nucleotide polymorphisms (SNPs) of genes involved in lipid metabolism and cardiometabolic-relatedphenotypes using a genetic risk score (GRS).Methods:We recruited 228 adults (mean age 36.5 years) who partici-pated in the Health Survey of Sa ̃o Paulo (HS-SP), Brazil. Clinical and anthropometric parameters, as well as the interactionbetween the GRS and the Brazilian Healthy Eating Index Revised (BHEI-R) were evaluated. We analyzed the relationshipbetween SNPs inAPOA5(rs662799),APOB(rs693, rs1367117),LDLR(rs688, rs5925) andLIPC(rs2070895, rs1800588) andcardiometabolic-related phenotypes using a GRS.Results:High-density lipoprotein cholesterol (HDLC) levels wereassociated with the BHEI-R (p¼0.026;b¼ 0.183) and with its SoFAAS component (solid fats, alcoholic beverages andadded sugars) (p¼0.007;b¼0.279). Non-HDL cholesterol levels were associated with the BHEI-R vegetable component(p¼0.015;b¼0.002) and the meat, eggs and beans component (p¼0.003;b¼0.007). Triacylglycerol levels were associatedwith the BHEI-R vegetable component (p¼0.027;b¼0.003); the meat, eggs and beans component (p¼0.041;b¼0.001);and the total protein component (p¼0.013;b¼0.032). Significant effects were observed for the interactions between theGRS and both the BHEI-R oils component (p¼0.019) and the SoFAAS component (p<0.001) on the dyslipidemia risk.Conclusions:The evaluation of dietary quality, especially fat quality, together with the lipid metabolism GRS could be auseful tool to manage cardiometabolic risk
- Imprenta:
- Source:
- Título: Nutrition And Health
- ISSN: 0260-1060
- Volume/Número/Paginação/Ano: v.25, n.2, p. 119-126, 2019
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
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ABNT
FUJII, Tatiane Mieko de Meneses et al. Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil. Nutrition And Health, v. 25, n. 2, p. 119-126, 2019Tradução . . Disponível em: https://doi.org/10.1177/0260106019830844. Acesso em: 29 dez. 2025. -
APA
Fujii, T. M. de M., Norde, M. M., Fisberg, R. M., Marchioni, D. M. L., & Rogero, M. M. (2019). Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil. Nutrition And Health, 25( 2), 119-126. doi:10.1177/0260106019830844 -
NLM
Fujii TM de M, Norde MM, Fisberg RM, Marchioni DML, Rogero MM. Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil [Internet]. Nutrition And Health. 2019 ;25( 2): 119-126.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1177/0260106019830844 -
Vancouver
Fujii TM de M, Norde MM, Fisberg RM, Marchioni DML, Rogero MM. Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil [Internet]. Nutrition And Health. 2019 ;25( 2): 119-126.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1177/0260106019830844 - FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women
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Informações sobre o DOI: 10.1177/0260106019830844 (Fonte: oaDOI API)
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