Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach (2020)
- Authors:
- USP affiliated authors: MARCHIONI, DIRCE MARIA LOBO - FSP ; FISBERG, REGINA MARA - FSP ; ALENCAR, GIZELTON PEREIRA - FSP ; TEIXEIRA, JULIANA ARAUJO - FSP ; GORGULHO, BARTIRA MENDES - FSP ; STELUTI, JOSIANE - FSP
- Unidade: FSP
- DOI: 10.1007/s00394-018-1886-8
- Subjects: HOMOCISTEÍNA; CARBONO; METABOLISMO; COMPORTAMENTO ALIMENTAR
- Agências de fomento:
- Language: Inglês
- Abstract: Purpose A structural equation model (SEM) was used to test multiple and simultaneous relationships between socio-demo-graphic factors, dietary patterns, biochemical levels of folate, vitamin B12, docosahexaenoic acid (DHA), and its effects on homocysteine (Hcy) level.Methods Socio-demographic and lifestyle characteristics, blood sample, anthropometric measurements, and a food-frequency questionnaire (FFQ) were obtained from 281 individuals of ISA-Capital study (Sao Paulo, Brazil). The dietary patterns (DP) were estimated using factor analysis with principal component’s estimation based on the frequency of daily intake derived from the 38-item FFQ. The SEM considered a theoretical model where the DP were expected to be directly associated with Hcy level, and indirectly via biochemical levels of folate, vitamin B12, and DHA. The variables sex, age, ethnicity, and MTHFR C677T polymorphism were included in the model.Results The Prudent DP (− 0.12, p = 0.04) had a negative effect, while MTHFR C677T polymorphism (0.16, p = 0.01), age (0.22, p < 0.01), and being man (0.16, p = 0.01) had a positive effect on Hcy level. There were no indirect effects of any dietary patterns on Hcy level, neither via folate, vitamin B12, nor DHA. DHA was negatively associated with the Modern DP (− 0.12, p = 0.04) and positively associated with the Prudent DP (0.19, p < 0.01).Conclusions The DP mainly composed of fruits and vegetables, natural juices, potato/cassava/cooked cornmeal, fish, and chicken, which was negatively associated with the Hcy level in this population. These findings support the role of a healthy dietary pattern in health outcomes, rather than promoting specific foods or nutrients, for policy-based health promotion strategies
- Imprenta:
- Source:
- Título: European Journal of Nutrition
- ISSN: 1436-6215
- Volume/Número/Paginação/Ano: v.59, n.1, p. 81-91, 2020
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
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ABNT
TEIXEIRA, Juliana Araujo et al. Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach. European Journal of Nutrition, v. 59, n. 1, p. 81-91, 2020Tradução . . Disponível em: https://doi.org/10.1007/s00394-018-1886-8. Acesso em: 14 fev. 2026. -
APA
Teixeira, J. A., Steluti, J., Gorgulho, B., Carioca, A. A. F., Alencar, G. P., Fisberg, R. M., & Marchioni, D. M. L. (2020). Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach. European Journal of Nutrition, 59( 1), 81-91. doi:10.1007/s00394-018-1886-8 -
NLM
Teixeira JA, Steluti J, Gorgulho B, Carioca AAF, Alencar GP, Fisberg RM, Marchioni DML. Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach [Internet]. European Journal of Nutrition. 2020 ;59( 1): 81-91.[citado 2026 fev. 14 ] Available from: https://doi.org/10.1007/s00394-018-1886-8 -
Vancouver
Teixeira JA, Steluti J, Gorgulho B, Carioca AAF, Alencar GP, Fisberg RM, Marchioni DML. Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach [Internet]. European Journal of Nutrition. 2020 ;59( 1): 81-91.[citado 2026 fev. 14 ] Available from: https://doi.org/10.1007/s00394-018-1886-8 - Presence of circulating folic acid in plasma and its relation with dietary intake, vitamin B complex concentrations and genetic variants
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Informações sobre o DOI: 10.1007/s00394-018-1886-8 (Fonte: oaDOI API)
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