Carbamoylimidazoles as potent cruzain inhibitors with in vitro and in vivo trypanocidal activity: a structure-based drug design approach (2019)
- Authors:
- USP affiliated authors: ANDRICOPULO, RENATA KROGH - IFSC ; OLIVA, GLAUCIUS - IFSC ; ANDRICOPULO, ADRIANO DEFINI - IFSC ; SOUZA, MARIANA LAUREANO DE - IFSC ; FERREIRA, LEONARDO LUIZ GOMES - IFSC ; MAGALHÃES, LUMA GODOY - IFSC
- Unidade: IFSC
- Subjects: DOENÇA DE CHAGAS; TRYPANOSOMA CRUZI; PLANEJAMENTO DE FÁRMACOS
- Keywords: Chagas' disease; Drug design; Structure-based drug design; Structure-activity relationships
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Anais eletrônicos
- Conference titles: Brazilian Symposium on Medicinal Chemistry - BrazMedChem
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ABNT
REZENDE JUNIOR, Celso et al. Carbamoylimidazoles as potent cruzain inhibitors with in vitro and in vivo trypanocidal activity: a structure-based drug design approach. 2019, Anais.. Campinas: Galoá, 2019. Disponível em: https://proceedings.science/p/107156. Acesso em: 13 fev. 2026. -
APA
Rezende Junior, C., Souza, M. L., Chavez, R., Ferreira, R. S., Slafer, B. W., Cruz, F. C., et al. (2019). Carbamoylimidazoles as potent cruzain inhibitors with in vitro and in vivo trypanocidal activity: a structure-based drug design approach. In Anais eletrônicos. Campinas: Galoá. Recuperado de https://proceedings.science/p/107156 -
NLM
Rezende Junior C, Souza ML, Chavez R, Ferreira RS, Slafer BW, Cruz FC, Ferreira LLG, Magalhães LG, Andricopulo RK, Oliva G, Andricopulo AD, Dias LC. Carbamoylimidazoles as potent cruzain inhibitors with in vitro and in vivo trypanocidal activity: a structure-based drug design approach [Internet]. Anais eletrônicos. 2019 ;[citado 2026 fev. 13 ] Available from: https://proceedings.science/p/107156 -
Vancouver
Rezende Junior C, Souza ML, Chavez R, Ferreira RS, Slafer BW, Cruz FC, Ferreira LLG, Magalhães LG, Andricopulo RK, Oliva G, Andricopulo AD, Dias LC. Carbamoylimidazoles as potent cruzain inhibitors with in vitro and in vivo trypanocidal activity: a structure-based drug design approach [Internet]. Anais eletrônicos. 2019 ;[citado 2026 fev. 13 ] Available from: https://proceedings.science/p/107156 - Discovery of potent, reversible, and competitive cruzain inhibitors with trypanocidal activity: a structure-based drug design approach
- Structure-based and molecular modeling studies for the discovery of cyclic imides as reversible cruzain inhibitors with potent anti-Trypanosoma cruzi activity
- Multiparameter optimization of Trypanocidal cruzain inhibitors with in vivo activity and favorable pharmacokinetics
- Synthesis and anti-trypanosoma cruzi activity of 3-cyanopyridine derivatives
- Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids
- Noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma Cruzi agents: synthesis, biological evaluation and structure-activity relationships
- Identification of carbamoylimidazoles as novel cruzain inhibitors with in vitro and in vivo trypanocidal activity
- Síntese, avaliação bioquímica e estudo das relações entre a estrutura e atividade de derivados imidazólicos inibidores da enzima cruzaína de Trypanosoma cruzi
- Virtual screening strategies for the discovery of new inhibitors of cruzain from Trypanosoma cruzi
- Avaliação da atividade tripanocida in vitro de derivados de chalconas como candidatos a agentes antichagásicos
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