Trabalho de evento-resumo

Genome sequencing of emphLeptospira inerogans serovar Copenhageni and comparative genome analysis (2004)

• Authors:
  • Nascimento, Ana L. T. O.
  • Martins, E. A. L.
  • Ho, P. L.
  • Leite, L. C. C.
  • Haake, D. A.
  • Verjovski-Almeida, Sergio
  • Hartskeerl, R. A.
  • Marques, Marilis do Valle
  • Menck, Carlos Frederico Martins
  • Ko, A. I.
  • Gamberini, M.
  • Junqueira-de-Azevedo, Inácio de Loiola Meirelles
  • Degrave, W. M.
  • Dellagostin, O. A.
  • Góes Neto, A.
  • Jerrônimo, S. M. B.
  • Schriefer, A.
  • Sommer, P.
  • Reis, M. S.
  • Simpson, A. J. G.
  • Ferro, J. A.
  • Kitajima, J. P.
  • Setubal, João Carlos
  • Consortium, A. E. G.
• USP affiliated authors: MARQUES, MARILIS DO VALLE - ICB ; MENCK, CARLOS FREDERICO MARTINS - ICB
• Unidade: ICB
• Assunto: MICROBIOLOGIA
• Language: Inglês
• Abstract: emphLeptospira species colonize a signi_cant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans (Faine et al.,1999, Leptospira and leptospirosis. MediSci, Melbourne, Australia). Complete genome sequencing of Leptospira interrogans serovar Copenhageni, and comparative analysis with the available Leptospira interrogans serovar Lai genome, reveal that despite overall genetic similarity there are signi_cant structural di_erences, including a large chromosomal inversion and extensive variation in number and distribution of insertion sequence elements (Nascimento, ALTO, et al., J. Bacteriol., 2004, in press). Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis. A broad array of transcriptional regulation proteins and two new families of a_mbrial adhesins were identi_- ed, which contribute to host tissue colonization in the early steps of infection. Di_erences between the Copenhageni and Lai serovars in genes involved in the biosynthesis of lipopolysaccharide O-side chains were identi_ed o_ering an important starting point for the elucidation of the organism _complex polysaccharide surface antigens. Hundreds of genes encoding surface-exposed lipoproteins and transmembrane outer membrane proteins were identi_ed as candidates fordevelopment as vaccines for prevention of leptospirosis
• Imprenta:
  • Publisher place: Caxambu
  • Date published: 2004
• Source:
  • Título do periódico: Programa e resumos
• Conference titles: Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq

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How to cite

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• ABNT

  NASCIMENTO, Ana L. T. O. et al. Genome sequencing of emphLeptospira inerogans serovar Copenhageni and comparative genome analysis. 2004, Anais.. Caxambu: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 09 dez. 2023.

• APA

  Nascimento, A. L. T. O., Martins, E. A. L., Ho, P. L., Leite, L. C. C., Haake, D. A., Verjovski-Almeida, S., et al. (2004). Genome sequencing of emphLeptospira inerogans serovar Copenhageni and comparative genome analysis. In Programa e resumos. Caxambu: Instituto de Ciências Biomédicas, Universidade de São Paulo.

• NLM

  Nascimento ALTO, Martins EAL, Ho PL, Leite LCC, Haake DA, Verjovski-Almeida S, Hartskeerl RA, Marques M do V, Menck CFM, Ko AI, Gamberini M, Junqueira-de-Azevedo I de LM, Degrave WM, Dellagostin OA, Góes Neto A, Jerrônimo SMB, Schriefer A, Sommer P, Reis MS, Simpson AJG, Ferro JA, Kitajima JP, Setubal JC, Consortium AEG. Genome sequencing of emphLeptospira inerogans serovar Copenhageni and comparative genome analysis. Programa e resumos. 2004 ;[citado 2023 dez. 09 ]

• Vancouver

  Nascimento ALTO, Martins EAL, Ho PL, Leite LCC, Haake DA, Verjovski-Almeida S, Hartskeerl RA, Marques M do V, Menck CFM, Ko AI, Gamberini M, Junqueira-de-Azevedo I de LM, Degrave WM, Dellagostin OA, Góes Neto A, Jerrônimo SMB, Schriefer A, Sommer P, Reis MS, Simpson AJG, Ferro JA, Kitajima JP, Setubal JC, Consortium AEG. Genome sequencing of emphLeptospira inerogans serovar Copenhageni and comparative genome analysis. Programa e resumos. 2004 ;[citado 2023 dez. 09 ]

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