Um novo modelo de camundongos geneticamente selecionados que apresentam alta resposta inflamatória aguda e o gene NAMP-1 de resistência, na ausência de C5 (2003)
- Authors:
- Autor USP: ISAAC, LOURDES - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Português
- Abstract: Two outbred mouse lines were selected according to a strong (AIRmax) or weak (AIRmin) acute inflammatory response. Considering that several mediators are derived from complement activation,our aim was to investigate if the intensity of the inflammatory response observed in AIRmax and AIRmin could be attributed to differences in the functionality of this system. Measuring the AP50 in each serum we observed significant differences between sera from male and female animals. However, no significant difference was observed between the two lines. AIRmax were shown to be more resistant than AIRmin to infection caused by [S. typhimurium]. Since the susceptibility to [S. typhimurium] is dependent on the [Nramp-1] gene and the resistant allele [(r)] is more frequent in AIRmax mice whereas the susceptible allele [(s)] is in AIRmin, we decided to analyse complement activity in sera from AIRmax and AIRmin homozygous for each allele of [Nramp-1] gene. Surprisingly, no hemolytic activity was found in any serum from AIRmax [r/r] mice and no C5 was detected by immunodiffusion against anti-C5. However, C5 was detected in AIRmax [s/s], AIRmin [r/r] and [s/s] serum and they presented normal hemolytic activity. In this manner, we have created a genetically selected group of outbred mice which have a strong acute inflammatory response, with a genotype for resistance to [S. thyphimurium] and lack of the component C5
- Imprenta:
- Publisher: Universidade de São Paulo
- Publisher place: São Paulo
- Date published: 2003
- Source:
- Título do periódico: Resumos
- Conference titles: Simpósio International de Iniciação Científica da Universidade de São Paulo, SIICUSP
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ABNT
AMANO, Mariane Tami et al. Um novo modelo de camundongos geneticamente selecionados que apresentam alta resposta inflamatória aguda e o gene NAMP-1 de resistência, na ausência de C5. 2003, Anais.. São Paulo: Universidade de São Paulo, 2003. . Acesso em: 20 abr. 2024. -
APA
Amano, M. T., Isaac, L., Carneiro, A. dos S., Starobinas, N., Ribeiro Filho, O. G., Ibañez, O. C. M., & Franco, M. de. (2003). Um novo modelo de camundongos geneticamente selecionados que apresentam alta resposta inflamatória aguda e o gene NAMP-1 de resistência, na ausência de C5. In Resumos. São Paulo: Universidade de São Paulo. -
NLM
Amano MT, Isaac L, Carneiro A dos S, Starobinas N, Ribeiro Filho OG, Ibañez OCM, Franco M de. Um novo modelo de camundongos geneticamente selecionados que apresentam alta resposta inflamatória aguda e o gene NAMP-1 de resistência, na ausência de C5. Resumos. 2003 ;[citado 2024 abr. 20 ] -
Vancouver
Amano MT, Isaac L, Carneiro A dos S, Starobinas N, Ribeiro Filho OG, Ibañez OCM, Franco M de. Um novo modelo de camundongos geneticamente selecionados que apresentam alta resposta inflamatória aguda e o gene NAMP-1 de resistência, na ausência de C5. Resumos. 2003 ;[citado 2024 abr. 20 ] - Ultrastructural aspects of alpha - 2 - macroglobulin activited mouse macrophages
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