Treadmill running protects spinal cord contusion from secondary degeneration (2003)
- Authors:
- Autor USP: CHADI, GERSON - ICB
- Unidade: ICB
- Assunto: ANATOMIA
- Language: Português
- Abstract: Objetivo: Physical activity exerts effects on central nervous system (CNS) since exercise triggers expression of neurotrophic molecules and stimulates CNS plasticity. Furthermore, it is possible that potential protective effects promoted by physical activity on lesioned CNS depend on the injury type. Métodos e Resultados: Adult rats, trained on a treadmill for 4 weeks, and sedentary rats were submitted to a moderate spinal cord injury by dropping a 10g rod (25mm distance) using the NYU Impactor. A group of sedentary rats were submitted to a sham operation. Rats received methypredinisolone just after the contusion and 2 hours later. Trained group has continued running on treadmill after spinal cord lesion for 4 weeks. The motor behavior was evaluated by BBB score and by a computerized infrared motion sensor activity monitor. After that period, animals were sacrificed and their spinal cords sectioned. The number of remaining neurons (RN), lesion areal fraction and lesion volume were obtained by stereological analysis methods.Decreased BBB scores were found in lesioned rats at the time-points, however a spontaneous recovery occurred post surgery. BBB score was smaller in the sedentary group compared to trained rats by 7 days post lesion (p<0.001 Anova), however no further differences were found between lesioned groups after 7 days. The infrared monitor also showed significant differences between lesioned sedentary and trained rats onlyat 7 days post spinal cord lesion (p<0.001, Anova). There are no significant differences in number of remaining neurons between sedentary (39x104 ± 3.84x104) and trained groups (44x104 ± 3.85x104). However, both groups are different when compared with sham group (56x104 ± 3.55x104). The lesion volume fraction [lesion volume (LV)/ total volume (TV)] were smaller in trained group than sedentary one (p<0.01, Anova Test) as well as the lesion and fraction per section (p<0.01, Anova). ) The lesion index (LI) was calculated multiplying the number of remaining neurons by the lesion volume fraction [LI = (LV/TV) o RN] (Chadi et al., Intern. J. Neuroscience, 111:137-16, 2001) and was more pronounced in sedentary group. Conclusões: Physical activity may protect lesioned spinal cord from secondary degeneration and may be important for functional recovery
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Curitiba, Paraná
- Date published: 2003
- Source:
- Título: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
-
ABNT
ANDRADE, M. S. R. de e CHADI, Gerson. Treadmill running protects spinal cord contusion from secondary degeneration. 2003, Anais.. Curitiba, Paraná: Federação de Sociedades de Biologia Experimental, 2003. . Acesso em: 15 out. 2024. -
APA
Andrade, M. S. R. de, & Chadi, G. (2003). Treadmill running protects spinal cord contusion from secondary degeneration. In Resumos. Curitiba, Paraná: Federação de Sociedades de Biologia Experimental. -
NLM
Andrade MSR de, Chadi G. Treadmill running protects spinal cord contusion from secondary degeneration. Resumos. 2003 ;[citado 2024 out. 15 ] -
Vancouver
Andrade MSR de, Chadi G. Treadmill running protects spinal cord contusion from secondary degeneration. Resumos. 2003 ;[citado 2024 out. 15 ] - Distribution of the bfgf immunoreactivity in the spinal cord and dorsal root ganglia of the adult rat
- On the presence of the bfgf immunoreactivity in the spinal cord and dorsal root ganglia of the adult rat
- Inoculation of schwann cells pre treated or not with inflammatory cytokines in the contuse lesioned rat spinal cord promoted rats submitted to by the nyu impactor alters the open field motor score (BBB)
- Basic fibroblast growth factor immunoreactivity in neurons and satellite cells of the myenteric plexus of the rodent ileum neuroregeneration
- Fetal alcohol syndrome: the usage of the stereological rotator to evaluate neurons throughout offspring life
- Efeito do alcolismo crônico na imunereatividade do neuropeptídeo Y no núcleo do tracto solitário e no núcleo paraventricular do hipotálamo do rato
- Basic fibroblast growth factor immunoreactivity after different degress of spinal cord contusion
- Effects of treadmill training on motor behavior, inclined plane and reflex response in rats
- Efeito estimulatório dos enxertos de células de schwann em associação com o gdnf no crescimento de fibras nervosas na transecção da medula espinhal em ratos
- Efeitos da atividade fisica espontânea na arborizacao dendritica de ratos submetidos a lesao estriatal isquemica pela endotelina-1
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas