Absence of CD28 leads to increased susceptibility to experimental Trypanosoma cruzi infection (2001)
- Authors:
- USP affiliated authors: RIZZO, LUIZ VICENTE - ICB ; SILVA, JOÃO SANTANA DA - FMRP
- Unidades: ICB; FMRP
- Assunto: IMUNOLOGIA
- Language: Inglês
- Abstract: In the present work we used mice deficient in the costimulatory molecule CD28 to study the implication of co-stimulation in the immune response against the Chagas disease causative parasite, Trypanosoma cruzi. Infection with this parasite causes many immunological disturbances in human and murine hosts, including a profound T cell unresponsiveness. The results showed that mice deficient in CD28 (CD28-/-) is highly susceptible to the infection with T. cruzi (Y and Colombian strains). As compared to the C57Bl/6 wild type mice (WT), the C57Bl/6CD28-/- mice (CD28-/-) presented about 8 fold higher parasitemia. Importantly, while all of the infected WT mice survived acute infection, 100% of the CD28-/- mice died until day 20 post infection. Kinetic analysis of nitric oxide (NO) production after infection showed that absence of CD28 renders a decreased ability to produce NO in the acute phase of infection. In addition, production of IFN-gamma in response to anti-CD3 or parasite soluble antigens was significantly decreased in spleen cells from CD28-/- infected mice as compared to the WT infected mice. Taken together, our findings suggest that CD28 is required for the establishment of a protective response to T. cruzi, by participating in the modulation of IFN-gamma and NO production after infection
- Imprenta:
- Publisher: Comissão de Cultura e Extensão Universitária do ICB-USP
- Publisher place: São Paulo
- Date published: 2001
- Source:
- Título: Resumos
- Conference titles: Congresso do Instituto de Ciências Biomédicas
-
ABNT
MARTINS, G. A. et al. Absence of CD28 leads to increased susceptibility to experimental Trypanosoma cruzi infection. 2001, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB-USP, 2001. . Acesso em: 29 dez. 2025. -
APA
Martins, G. A., Campanelli, A. P., Tadokoro, C. E., Vallochi, A., Rizzo, L. V., & Silva, J. S. da. (2001). Absence of CD28 leads to increased susceptibility to experimental Trypanosoma cruzi infection. In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB-USP. -
NLM
Martins GA, Campanelli AP, Tadokoro CE, Vallochi A, Rizzo LV, Silva JS da. Absence of CD28 leads to increased susceptibility to experimental Trypanosoma cruzi infection. Resumos. 2001 ;[citado 2025 dez. 29 ] -
Vancouver
Martins GA, Campanelli AP, Tadokoro CE, Vallochi A, Rizzo LV, Silva JS da. Absence of CD28 leads to increased susceptibility to experimental Trypanosoma cruzi infection. Resumos. 2001 ;[citado 2025 dez. 29 ] - Absence of CD28 leads to increased susceptibility to experimental Trypanosoma cruzi infections
- CD28 is requered for protective immunity against the intracellular protozoan Trypanosoma cruzi
- CTLA-4 blockage increases reistance to infection with the intracellular protozaon Trypanossoma cruzi
- Mice deficient in (CD28-/-) are highly susceptible to Trypanosoma cruzi infection
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- Involvement of nitric oxide (NO) and TNF-A in the anemia and in the oxidative stress in erythrocytes from mice susceptible and resistant to Tripanossoma Cruzi infection
- Análise da sobrevida do transplante de limbo e conjuntiva e membrana amniótica para a reconstrução da superfície ocular na deficiência límbica total
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