Artigo de periodico

Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock (2018)

• Authors:
  • Costa, Nara Aline - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Rogero, Marcelo Macedo
  • Norde, Marina Maintinguer
  • Minicucci, Marcos Ferreira - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Cunha, Natália Baraldi - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Gut, Ana Lúcia - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Azevedo, Paula Schmidt - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Polegato, Bertha Furlan - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Zornoff, Leonardo Antonio Mamede - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Paiva, Sérgio Alberto Rupp de - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
  • Reis, Bruna Zavarize
  • Fernandes, Ana Angelica Henrique - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
• USP affiliated authors: ROGERO, MARCELO MACEDO - FSP ; NORDE, MARINA MAINTINGUER - FSP ; REIS, BRUNA ZAVARIZE - FCF
• Unidades: FSP; FCF
• DOI: 10.1016/j.freeradbiomed.2018.06.013
• Subjects: CHOQUE SÉPTICO; MORTALIDADE; UNIDADES DE TERAPIA INTENSIVA; ESTRESSE OXIDATIVO
• Agências de fomento:
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
    Processo FAPESP: 2014/17262-0
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
    Processo FAPESP: 2014/07988-4
• Language: Inglês
• Abstract: The objective of our study was to evaluate the influence of the superoxide dismutase 1 (SOD1)polymorphismson erythrocyte SOD1 activity and the mortality of patients with septic shock. We prospectively evaluated 175patients aged over 18 years with septic shock upon ICU admission. However, 38 patients were excluded. Thus,137 patients were enrolled in the study. Blood samples were taken within thefirst 24 h of the patient's admissionto determine erythrocyte SOD1 activity and nineSOD1gene polymorphisms. The mean patient age was 63 ± 16years, 58% were men, and ICU mortality rate was 66%. The patients who died were older and more severely ill,with higher Acute Physiology and Chronic Health Evaluation (APACHE II) and Sequential Organ FailureAssessment (SOFA) scores, as well as higher lactate, urea, and protein carbonyl levels. In the logistic regressionmodel, erythrocyte SOD1 activity was associated with ICU mortality. This relationship was also maintained inthe highest tertile of SOD1 activity (odds ratio [OR]: 0.02; 95% confidence interval [CI]: 0.00–0.78; p = 0.037).Only SNP rs2070424 of theSOD1gene influenced erythrocyte SOD1 activity. For patients with the AA allele, theactivity of SOD1 was lower in relation to G-carriers (A/G+G/G genotype) (p = 0.019). None of the nineSOD1SNPs were associated with ICU mortality. In conclusion, the SNP rs2070424 of theSOD1gene interferes witherythrocyte SOD1 activity, and higher activity of SOD1 was associated with decreased mortality in patients withseptic shock
• Imprenta:
  • Publisher place: New York
  • Date published: 2018
• Source:
  • Título do periódico: Free Radical Biology and Medicine
  • ISSN: 0891-5849
  • Volume/Número/Paginação/Ano: v.124, p.199-204, 2018

Informações sobre o DOI: 10.1016/j.freeradbiomed.2018.06.013 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo é de acesso aberto
• URL de acesso aberto
• Cor do Acesso Aberto: hybrid
• Licença: unspecified-oa

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How to cite

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• ABNT

  COSTA, Nara Aline et al. Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock. Free Radical Biology and Medicine, v. 124, p. 199-204, 2018Tradução . . Disponível em: https://doi.org/10.1016/j.freeradbiomed.2018.06.013. Acesso em: 18 set. 2024.

• APA

  Costa, N. A., Rogero, M. M., Norde, M. M., Minicucci, M. F., Cunha, N. B., Gut, A. L., et al. (2018). Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock. Free Radical Biology and Medicine, 124, 199-204. doi:10.1016/j.freeradbiomed.2018.06.013

• NLM

  Costa NA, Rogero MM, Norde MM, Minicucci MF, Cunha NB, Gut AL, Azevedo PS, Polegato BF, Zornoff LAM, Paiva SAR de, Reis BZ, Fernandes AAH. Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock [Internet]. Free Radical Biology and Medicine. 2018 ;124 199-204.[citado 2024 set. 18 ] Available from: https://doi.org/10.1016/j.freeradbiomed.2018.06.013

• Vancouver

  Costa NA, Rogero MM, Norde MM, Minicucci MF, Cunha NB, Gut AL, Azevedo PS, Polegato BF, Zornoff LAM, Paiva SAR de, Reis BZ, Fernandes AAH. Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock [Internet]. Free Radical Biology and Medicine. 2018 ;124 199-204.[citado 2024 set. 18 ] Available from: https://doi.org/10.1016/j.freeradbiomed.2018.06.013

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