Biological and biophysical investigation of Plasmodium falciparum Pyruvate Kinase II (PKII) as a new molecular target for antimalarial drug discovery (2025)
- Authors:
- USP affiliated authors: GUIDO, RAFAEL VICTÓRIO CARVALHO - IFSC ; MARTINS, JOÃO PEDRO SALAZAR - IFSC ; OLIVEIRA, GABRIELA SILVA DE - IFSC ; MOURA, IGOR MOTA RODRIGUES DE - IFSC ; BONATTO, VINÍCIUS - IFSC
- Unidade: IFSC
- Subjects: PROTEÍNAS; MALÁRIA; ANTIMALÁRICOS; PLASMODIUM FALCIPARUM; BIOFÍSICA
- Keywords: Malaria; P. falciparum; Pyruvate Kinase
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher: Universidade Federal do Rio de Janeiro - UFRJ
- Publisher place: Rio de Janeiro
- Date published: 2025
- Source:
- Título: Annals
- Conference titles: Brazilian Symposium on Medicinal Chemistry - BrazMedChem
-
ABNT
MARTINS, João Pedro Salazar et al. Biological and biophysical investigation of Plasmodium falciparum Pyruvate Kinase II (PKII) as a new molecular target for antimalarial drug discovery. 2025, Anais.. Rio de Janeiro: Universidade Federal do Rio de Janeiro - UFRJ, 2025. Disponível em: https://repositorio.usp.br/directbitstream/66910171-c5b3-4cee-98ca-4564dffc9015/3290527.pdf. Acesso em: 23 fev. 2026. -
APA
Martins, J. P. S., Oliveira, G. S. de, Moura, I. M. R. de, Bonatto, V., & Guido, R. V. C. (2025). Biological and biophysical investigation of Plasmodium falciparum Pyruvate Kinase II (PKII) as a new molecular target for antimalarial drug discovery. In Annals. Rio de Janeiro: Universidade Federal do Rio de Janeiro - UFRJ. Recuperado de https://repositorio.usp.br/directbitstream/66910171-c5b3-4cee-98ca-4564dffc9015/3290527.pdf -
NLM
Martins JPS, Oliveira GS de, Moura IMR de, Bonatto V, Guido RVC. Biological and biophysical investigation of Plasmodium falciparum Pyruvate Kinase II (PKII) as a new molecular target for antimalarial drug discovery [Internet]. Annals. 2025 ;[citado 2026 fev. 23 ] Available from: https://repositorio.usp.br/directbitstream/66910171-c5b3-4cee-98ca-4564dffc9015/3290527.pdf -
Vancouver
Martins JPS, Oliveira GS de, Moura IMR de, Bonatto V, Guido RVC. Biological and biophysical investigation of Plasmodium falciparum Pyruvate Kinase II (PKII) as a new molecular target for antimalarial drug discovery [Internet]. Annals. 2025 ;[citado 2026 fev. 23 ] Available from: https://repositorio.usp.br/directbitstream/66910171-c5b3-4cee-98ca-4564dffc9015/3290527.pdf - Biochemical, biophysical and structural characterization of cGMPdependent protein kinase (PKG) from Plasmodium falciparum
- Estudos de modelagem molecular para a descoberta de potenciais inibidores da enzima PI4KIIIβ de Plasmodium falciparum: triagem virtual e métodos de aprendizado de máquina
- Unraveling the dual inhibition of Plasmodium falciparum PI4K and PKG by sapanisertib through alchemical free energy calculations
- Discovery of thio-phosphoranes as P. falciparum inhibitors active against sensitive and resistant strains
- Estudos de biologia estrutural e química medicinal para descoberta de inibidores da enzima piruvato quinase II de Plasmodium falciparum
- Discovery of tannic acid as a non-competitive inhibitor of Plasmodium falciparum Pyruvate Kinase II with fast-acting inhibitory activity against the malaria parasites
- Expressão heteróloga e caracterização biofísica da proteína PKG de P. falciparum
- Tandem mass spectrometry and bio-guided isolation of secondary metabolites with antiplasmodial activity from Dalbergia miscolobium bark
- Mode-of-action investigation of a new generation of acridine/acridonebased antimalarials
- Clonagem e expressão da quinase plasmodial CLK3
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