Biochemical, biophysical and structural characterization of cGMPdependent protein kinase (PKG) from Plasmodium falciparum (2025)
- Authors:
- USP affiliated authors: GUIDO, RAFAEL VICTÓRIO CARVALHO - IFSC ; OLIVEIRA, GABRIELA SILVA DE - IFSC ; MARTINS, JOÃO PEDRO SALAZAR - IFSC ; MOURA, IGOR MOTA RODRIGUES DE - IFSC ; VALDES, TALITA ALVARENGA - IFSC ; BONATTO, VINÍCIUS - IFSC ; NOSKE, GABRIELA DIAS - IFSC
- Unidade: IFSC
- Subjects: PROTEÍNAS; MALÁRIA; ANTIMALÁRICOS; PLASMODIUM FALCIPARUM; BIOFÍSICA
- Keywords: Malaria; Kinase; PfPKG; Crystallography; Inhibitors; Antiplasmodial
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher: Universidade Federal do Rio de Janeiro - UFRJ
- Publisher place: Rio de Janeiro
- Date published: 2025
- Source:
- Título: Annals
- Conference titles: Brazilian Symposium on Medicinal Chemistry - BrazMedChem
-
ABNT
OLIVEIRA, Gabriela Silva de et al. Biochemical, biophysical and structural characterization of cGMPdependent protein kinase (PKG) from Plasmodium falciparum. 2025, Anais.. Rio de Janeiro: Universidade Federal do Rio de Janeiro - UFRJ, 2025. Disponível em: https://repositorio.usp.br/directbitstream/83a220f8-e966-4e96-9911-ce36bb6429bd/3290414.pdf. Acesso em: 23 fev. 2026. -
APA
Oliveira, G. S. de, Martins, J. P. S., Moura, I. M. R. de, Valdes, T. A., Bonatto, V., Noske, G. D., & Guido, R. V. C. (2025). Biochemical, biophysical and structural characterization of cGMPdependent protein kinase (PKG) from Plasmodium falciparum. In Annals. Rio de Janeiro: Universidade Federal do Rio de Janeiro - UFRJ. Recuperado de https://repositorio.usp.br/directbitstream/83a220f8-e966-4e96-9911-ce36bb6429bd/3290414.pdf -
NLM
Oliveira GS de, Martins JPS, Moura IMR de, Valdes TA, Bonatto V, Noske GD, Guido RVC. Biochemical, biophysical and structural characterization of cGMPdependent protein kinase (PKG) from Plasmodium falciparum [Internet]. Annals. 2025 ;[citado 2026 fev. 23 ] Available from: https://repositorio.usp.br/directbitstream/83a220f8-e966-4e96-9911-ce36bb6429bd/3290414.pdf -
Vancouver
Oliveira GS de, Martins JPS, Moura IMR de, Valdes TA, Bonatto V, Noske GD, Guido RVC. Biochemical, biophysical and structural characterization of cGMPdependent protein kinase (PKG) from Plasmodium falciparum [Internet]. Annals. 2025 ;[citado 2026 fev. 23 ] Available from: https://repositorio.usp.br/directbitstream/83a220f8-e966-4e96-9911-ce36bb6429bd/3290414.pdf - Biological and biophysical investigation of Plasmodium falciparum Pyruvate Kinase II (PKII) as a new molecular target for antimalarial drug discovery
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- Estudos de modelagem molecular para a descoberta de potenciais inibidores da enzima PI4KIIIβ de Plasmodium falciparum: triagem virtual e métodos de aprendizado de máquina
- Evaluation of antiplasmodial activity of atovaquone-based compounds against sensitive and multidrug-resistant Plasmodium falciparum strains
- Design, synthesis and evaluation of the antimalarial activity of chromenes obtained by Hantzsch multicomponent reactions
- Unraveling the dual inhibition of Plasmodium falciparum PI4K and PKG by sapanisertib through alchemical free energy calculations
- Fluorescent marinoquinoline derivative as inhibitors of Plasmodium falciparum: SAR analysis, mode of action and in vivo studies
- Discovery of thio-phosphoranes as P. falciparum inhibitors active against sensitive and resistant strains
- Estudos de biologia estrutural e química medicinal para descoberta de inibidores da enzima piruvato quinase II de Plasmodium falciparum
- Discovery of tannic acid as a non-competitive inhibitor of Plasmodium falciparum Pyruvate Kinase II with fast-acting inhibitory activity against the malaria parasites
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