Artigo de periodico

Design and synthesis of novel 3-nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted analogs as promising antitrypanosomatid agents: evaluation of in vitro activity against chagas disease and leishmaniasis (2024)

• Authors:
  • Pelizaro, Bruno I
  • Batista, Jaqueline C. Z
  • Portapilla, Gisele Bulhões
  • Neves, Amarith R. das
  • Silva, Fernanda
  • Carvalho, Diego B
  • Shiguemoto, Cristiane Y. K
  • Pessatto, Lucas R
  • Paredes-Gamero, Edgar J
  • Cardoso, Iara Aimê
  • Luccas, Pedro Henrique
  • Nonato, Maria Cristina
  • Lopes, Norberto Peporine
  • Galvão, Fernanda
  • Oliveira, Kelly M. P
  • Cassemiro, Nadla S
  • Silva, Denise B
  • Piranda, Eliane M
  • Arruda, Carla C. P
  • Albuquerque, Sérgio de
  • Baroni, Adriano C. M
• USP affiliated authors: CARDOSO, IARA AIMÊ - FCFRP ; NONATO, MARIA CRISTINA - FCFRP ; LOPES, NORBERTO PEPORINE - FCFRP ; ALBUQUERQUE, SÉRGIO DE - PUSP-RP ; LUCCAS, PEDRO HENRIQUE - FCFRP ; PORTAPILLA, GISELE BULHÕES - FCFRP
• Unidades: FCFRP; PUSP-RP
• DOI: 10.1021/acs.jmedchem.3c01745
• Subjects: DOENÇA DE CHAGAS; LEISHMANIOSE CUTÂNEA; TRIPANOSSOMOSE; EPIDEMIOLOGIA EXPERIMENTAL
• Agências de fomento:
  • Financiamento CNPq
  • Financiamento FUNDECT
  • Financiamento CAPES
• Language: Inglês
• Imprenta:
  • Publisher place: Washington
  • Date published: 2024
• Source:
  • Título: Journal of Medicinal Chemistry
  • ISSN: 0022-2623
  • Volume/Número/Paginação/Ano: v. 67, n. 4, p. 2584-2601, 2024

Informações sobre o DOI: 10.1021/acs.jmedchem.3c01745 (Fonte: oaDOI API)
• Este periódico é de acesso aberto
• Este artigo NÃO é de acesso aberto
  

---

How to cite

A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

• ABNT

  PELIZARO, Bruno I et al. Design and synthesis of novel 3-nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted analogs as promising antitrypanosomatid agents: evaluation of in vitro activity against chagas disease and leishmaniasis. Journal of Medicinal Chemistry, v. 67, n. 4, p. 2584-2601, 2024Tradução . . Disponível em: https://doi.org/10.1021/acs.jmedchem.3c01745. Acesso em: 22 jan. 2026.

• APA

  Pelizaro, B. I., Batista, J. C. Z., Portapilla, G. B., Neves, A. R. das, Silva, F., Carvalho, D. B., et al. (2024). Design and synthesis of novel 3-nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted analogs as promising antitrypanosomatid agents: evaluation of in vitro activity against chagas disease and leishmaniasis. Journal of Medicinal Chemistry, 67( 4), 2584-2601. doi:10.1021/acs.jmedchem.3c01745

• NLM

  Pelizaro BI, Batista JCZ, Portapilla GB, Neves AR das, Silva F, Carvalho DB, Shiguemoto CYK, Pessatto LR, Paredes-Gamero EJ, Cardoso IA, Luccas PH, Nonato MC, Lopes NP, Galvão F, Oliveira KMP, Cassemiro NS, Silva DB, Piranda EM, Arruda CCP, Albuquerque S de, Baroni ACM. Design and synthesis of novel 3-nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted analogs as promising antitrypanosomatid agents: evaluation of in vitro activity against chagas disease and leishmaniasis [Internet]. Journal of Medicinal Chemistry. 2024 ; 67( 4): 2584-2601.[citado 2026 jan. 22 ] Available from: https://doi.org/10.1021/acs.jmedchem.3c01745

• Vancouver

  Pelizaro BI, Batista JCZ, Portapilla GB, Neves AR das, Silva F, Carvalho DB, Shiguemoto CYK, Pessatto LR, Paredes-Gamero EJ, Cardoso IA, Luccas PH, Nonato MC, Lopes NP, Galvão F, Oliveira KMP, Cassemiro NS, Silva DB, Piranda EM, Arruda CCP, Albuquerque S de, Baroni ACM. Design and synthesis of novel 3-nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted analogs as promising antitrypanosomatid agents: evaluation of in vitro activity against chagas disease and leishmaniasis [Internet]. Journal of Medicinal Chemistry. 2024 ; 67( 4): 2584-2601.[citado 2026 jan. 22 ] Available from: https://doi.org/10.1021/acs.jmedchem.3c01745

Últimas obras dos mesmos autores vinculados com a USP cadastradas na BDPI:

• Repurposing of 5-nitrofuran-3,5-disubstituted isoxazoles: a thriving scaffold to antitrypanosomal agents
• New 2-nitroimidazole-N-acylhydrazones, analogs of benznidazole, as anti-Trypanosoma cruzi agents
• Characterization of class II fumarase from Schistosoma mansoni provides the molecular basis for selective inhibition
• Human fumarase cocrystallization: revealing metabolitefumarase interactions
• Effect of fluorination on the structure and anti-Trypanosoma cruzy activity of oxorhenium(V) complexes with S,N,S-tridentate thiosemicarbazones and benzoylthioureas. Synthesis and structures of technetium(V) analogues
• Synthesis and antitrypanosomal activity of 1,4-disubstituted triazole compounds based on a 2-nitroimidazole scaffold: a structure-activity relationship study
• Desenvolvimento de protocolo de ensaio de atividade baseado em fluorescência e avaliação de novos substratos para a enzima nitroredutase de Trypanosoma cruzi
• Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole
• Trypanocidal activity of new 1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine derivatives: synthesis, in vitro and in vivo studies
• Organometallic gold(III) complexes with tridentate halogen‐substituted thiosemicarbazones: effects of halogenation on cytotoxicity and anti‐parasitic activity