Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease (2025)
- Authors:
- USP affiliated authors: MONTANARI, CARLOS ALBERTO - IQSC ; BONATTO, VINÍCIUS - IQSC
- Unidade: IQSC
- DOI: 10.1002/pro.70283
- Subjects: TRYPANOSOMA CRUZI; DOENÇA DE CHAGAS
- Keywords: Cruzain; Cys25; Molecular dynamics simulations; Protonation state
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Protein Science
- ISSN: 1469-896X
- Volume/Número/Paginação/Ano: p.e70283, v.34, 2025
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
-
ABNT
COSTA, Clauber H. S. da et al. Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease. Protein Science, v. 34, p. e70283, 2025Tradução . . Disponível em: https://doi.org/10.1002/pro.70283. Acesso em: 14 fev. 2026. -
APA
Costa, C. H. S. da, Bonatto, V., Santos, H. B. T., Souza, C. G. da S. de, Montanari, C. A., Skaf, M. S., et al. (2025). Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease. Protein Science, 34, e70283. doi:10.1002/pro.70283 -
NLM
Costa CHS da, Bonatto V, Santos HBT, Souza CG da S de, Montanari CA, Skaf MS, Luque FJ, Lameira J. Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease [Internet]. Protein Science. 2025 ; 34e70283.[citado 2026 fev. 14 ] Available from: https://doi.org/10.1002/pro.70283 -
Vancouver
Costa CHS da, Bonatto V, Santos HBT, Souza CG da S de, Montanari CA, Skaf MS, Luque FJ, Lameira J. Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease [Internet]. Protein Science. 2025 ; 34e70283.[citado 2026 fev. 14 ] Available from: https://doi.org/10.1002/pro.70283 - A new strategy to model the mechanism of action of covalent inhibitors
- Evaluating QM/MM Free Energy Surfaces for Ranking Cysteine Protease Covalent Inhibitors
- Modelagem molecular de inibidores covalentes reversíveis de cisteíno proteases
- Exploring Nirmatrelvir derivatives through P2 substituent modifications and warhead innovations targeting the main protease of SARS-CoV-2
- Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations
- Nitriles: an attractive approach to the development of covalent inhibitors
- A patent review on cathepsin K inhibitors to treat osteoporosis (2011 – 2021)
- Predicting the affinity of halogenated reversible covalent inhibitors through relative binding free energy
- Predicting the ΔΔGbind of halogenated reversible covalent inhibitors of hCatL through computer simulation
- Falcipain-2a mediated resistance to peptide-like inhibitors in Plasmodium falciparum
Informações sobre o DOI: 10.1002/pro.70283 (Fonte: oaDOI API)
Download do texto completo
| Tipo | Nome | Link | |
|---|---|---|---|
| P22336.pdf | Direct link |
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
