Trabalho de evento-resumo

Amphiphilic, Stimuli-Responsive Candidates for Nanoreactors (2018)

• Authors:
  • Souza, Valdomiro Vagner de
  • Lima Júnior, Cícero Alves
  • Melo, Carolina da Silva
  • Carretero, Gustavo Penteado Battesini
  • Florenzano, Fabio Herbst
  • Cuccovia, Iolanda Midea
  • Chaimovich, Hernan
• USP affiliated authors: GURALNIK, HERNAN CHAIMOVICH - IQ ; FLORENZANO, FÁBIO HERBST - EEL ; CUCCOVIA, IOLANDA MIDEA - IQ ; MELO, CAROLINA DA SILVA - EEL ; SOUZA, VALDOMIRO VAGNER DE - IQ ; LIMA JÚNIOR, CICERO ALVES - IQ ; CARRETERO, GUSTAVO PENTEADO BATTESINI - IQ
• Unidades: IQ; EEL
• Subjects: POLÍMEROS (MATERIAIS); NANOTECNOLOGIA
• Keywords: RAFT; Nanoreactors; Polymersomes
• Agências de fomento:
  • Financiamento CNPq
  • Financiamento INCT-FCx
  • Financiamento FAPESP
• Language: Inglês
• Abstract: Polymersomes, vesicles formed by amphiphilic copolymers, are more structured than lipid vesicles and can be used as nanoreactors, aggregates that can sequester reagents or enzymes in the internal compartment, shielding them from external agents and facilitating their transport and applications in the most diverse environments. OBJECTIVES: Obtaining stimuli-responsive amphiphilic copolymers capable of forming polymersomes. MATERIALS AND METHODS: Poly(dimethylaminoethylmethacrylateblock-polystyrene), PDMAEMA-b-Sty, copolymers were synthesized using RAFT (Reversible Addition-Fragmentation Chain Transfer). The copolymers were characterized by SEC-IR, FTIR and 1H/NMR. Hydrodynamic diameters were measured by DLS. The presence of a hydrophilic compartment in the polymersomes was estimated by EPR, as follows: polymersomes were prepared in a solution containing a spin label followed by the addition of ascorbic acid that suppress probe’s signal outside the vesicle. Residual EPR signal was assigned to the existence of an internal aqueous compartment. RESULTS AND DISCUSSION: Chemically characterized (NMR, FTIR, SEC-IR) amphiphilic block copolymers were obtained. Polymers responded to pH and temperature by changing their aggregation pattern. Under simple compatible solvent dissolution, the polymers assembled into aggregates with dimensions that match with the formation of vesicles (polymersomes). Entrapment of EPR probes indicated that the polymersomes possessed internal aqueous compartments of 0.59 and 0.53 % of sample’s total volume (1mg of copolymer in 1mL solution), respectively for PDMAEMA315-b-Sty244 and PDMAEMA315-b-Sty781. CONCLUSION: Stimuli-responsive amphiphilic copolymers capable of assembling into polymersomes that can be used as nanoreactors or drug delivery systems were synthesized and characterized.
• Imprenta:
  • Publisher: SBBq
  • Publisher place: Joinville
  • Date published: 2018
• Source:
  • Título: Anais da 47a. Reunião Anual da Sociedade Brasileira de Bioquímica de Biologia Molecular


---

How to cite

A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

• ABNT

  SOUZA, Valdomiro Vagner de et al. Amphiphilic, Stimuli-Responsive Candidates for Nanoreactors. 2018, Anais.. Joinville: SBBq, 2018. Disponível em: https://www2.sbbq.org.br/reuniao/2018/livro_resumos_2018.pdf. Acesso em: 02 abr. 2026.

• APA

  Souza, V. V. de, Lima Júnior, C. A., Melo, C. da S., Carretero, G. P. B., Florenzano, F. H., Cuccovia, I. M., & Chaimovich, H. (2018). Amphiphilic, Stimuli-Responsive Candidates for Nanoreactors. In Anais da 47a. Reunião Anual da Sociedade Brasileira de Bioquímica de Biologia Molecular. Joinville: SBBq. Recuperado de https://www2.sbbq.org.br/reuniao/2018/livro_resumos_2018.pdf

• NLM

  Souza VV de, Lima Júnior CA, Melo C da S, Carretero GPB, Florenzano FH, Cuccovia IM, Chaimovich H. Amphiphilic, Stimuli-Responsive Candidates for Nanoreactors [Internet]. Anais da 47a. Reunião Anual da Sociedade Brasileira de Bioquímica de Biologia Molecular. 2018 ;[citado 2026 abr. 02 ] Available from: https://www2.sbbq.org.br/reuniao/2018/livro_resumos_2018.pdf

• Vancouver

  Souza VV de, Lima Júnior CA, Melo C da S, Carretero GPB, Florenzano FH, Cuccovia IM, Chaimovich H. Amphiphilic, Stimuli-Responsive Candidates for Nanoreactors [Internet]. Anais da 47a. Reunião Anual da Sociedade Brasileira de Bioquímica de Biologia Molecular. 2018 ;[citado 2026 abr. 02 ] Available from: https://www2.sbbq.org.br/reuniao/2018/livro_resumos_2018.pdf

Últimas obras dos mesmos autores vinculados com a USP cadastradas na BDPI:

• Nanoparticles of PMMA-b-PDMAEMA for gene delivery - P202
• Polymersomes of poly (dimethylaminoethylmethacrylate-block-polystyrene): amphiphilic, stimuliresponsive candidates for nanoreactors
• Naphthalimide-containing BP100 leads to higher model membranes interactions and antimicrobial activity
• Stimuli-responsive polymersomes of poly [2-(dimethylamino) ethyl methacrylate]-b-polystyrene
• Caracterização do copolímero PMMA(1)-b-PDMAEMA(1,3) e estudo do seu efeito sobre a permeabilidade de vesículas de fosfolipídios
• Caracterização do copolímero PMMA (1) - b - PDMAEMA (6,3) e estudo da permeabilização de vesículas preparadas com fosfolipídios
• Study of the effect of copolymer structure on the permeability of phospholipid vesicles
• Efeito de pH e composição de fosfolipídicos na interação do copolímero 'PMMA IND. 1'-Ь-'PDMAEMA IND. 6,3' com vesículas
• Mecanismos de ação do copolímero 'PMMA IND. 1'-Ь-'PDMAEMA IND. 3' em modelos de membrana com diferentes cargas
• Explorando padrões estruturais de polímeros na interação com vesículas de fosfolipidios