Artigo de periodico

A novel Ruthenium(II) complex with lapachol induces G2/M phase arrest through Aurora-B kinase down-regulation and ROS-mediated apoptosis in human prostate adenocarcinoma cells (2021)

• Authors:
  • De Grandis, Rone A
  • Oliveira, Katia M
  • Guedes, Adriana P. M
  • Santos, Patrick Wellington da Silva dos
  • Aissa, Alexandre F
  • Batista, Alzir A
  • Pavan, Fernando R
• Autor USP: SANTOS, PATRICK WELLINGTON DA SILVA DOS - FMRP
• Unidade: FMRP
• DOI: 10.3389/fonc.2021.682968
• Subjects: APOPTOSE; ADENOCARCINOMA; PRÓSTATA; NEOPLASIAS DOS GENITAIS MASCULINOS
• Keywords: 3D-cell culture; DNA damage (comet assay); ROS - reactive oxygen species; Apoptosis; Lapachol; Naphtoquinones
• Agências de fomento:
  • Financiamento CNPq
  • Financiamento CAPES
  • Financiamento FAPESP
• Language: Inglês
• Imprenta:
  • Publisher place: Lausanne
  • Date published: 2021
• Source:
  • Título: Frontiers in Oncology
  • ISSN: 2234-943X
  • Volume/Número/Paginação/Ano: v. 11, art. 682968, [18] p, 2021


Informações sobre a disponibilidade de versões do artigo em acesso aberto coletadas automaticamente via oaDOI API (Unpaywall).

Status:

Artigo publicado em periódico de acesso aberto (Gold Open Access)

Versão do Documento:

Versão publicada (Published version)

Acessar versão aberta:

• PDF de acesso aberto

Por se tratar de integração com serviço externo, podem existir diferentes versões do trabalho (como preprints ou postprints), que podem diferir da versão publicada.

---

Download do texto completo

Tipo	Nome	Link
	003228734.pdf	Direct link

How to cite

A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

• ABNT

  DE GRANDIS, Rone A et al. A novel Ruthenium(II) complex with lapachol induces G2/M phase arrest through Aurora-B kinase down-regulation and ROS-mediated apoptosis in human prostate adenocarcinoma cells. Frontiers in Oncology, v. 11, 2021Tradução . . Disponível em: https://doi.org/10.3389/fonc.2021.682968. Acesso em: 01 abr. 2026.

• APA

  De Grandis, R. A., Oliveira, K. M., Guedes, A. P. M., Santos, P. W. da S. dos, Aissa, A. F., Batista, A. A., & Pavan, F. R. (2021). A novel Ruthenium(II) complex with lapachol induces G2/M phase arrest through Aurora-B kinase down-regulation and ROS-mediated apoptosis in human prostate adenocarcinoma cells. Frontiers in Oncology, 11. doi:10.3389/fonc.2021.682968

• NLM

  De Grandis RA, Oliveira KM, Guedes APM, Santos PW da S dos, Aissa AF, Batista AA, Pavan FR. A novel Ruthenium(II) complex with lapachol induces G2/M phase arrest through Aurora-B kinase down-regulation and ROS-mediated apoptosis in human prostate adenocarcinoma cells [Internet]. Frontiers in Oncology. 2021 ; 11[citado 2026 abr. 01 ] Available from: https://doi.org/10.3389/fonc.2021.682968

• Vancouver

  De Grandis RA, Oliveira KM, Guedes APM, Santos PW da S dos, Aissa AF, Batista AA, Pavan FR. A novel Ruthenium(II) complex with lapachol induces G2/M phase arrest through Aurora-B kinase down-regulation and ROS-mediated apoptosis in human prostate adenocarcinoma cells [Internet]. Frontiers in Oncology. 2021 ; 11[citado 2026 abr. 01 ] Available from: https://doi.org/10.3389/fonc.2021.682968

Últimas obras dos mesmos autores vinculados com a USP cadastradas na BDPI:

• Influência do sulforafano, um inibidor de histonas desacetilases, sobre a instabilidade genômica e mecanismos epigenéticos em linhagens celulares humanas
• Sulforaphane combined with vitamin D induces cytotoxicity mediated by oxidative stress, DNA damage, autophagy, and JNK/MAPK pathway modulation in human prostate tumor cells
• Role of exosomal miRNAs and the tumor microenvironment in drug resistance
• Diallyl disulfide induces chemosensitization to sorafenib, autophagy, and cell cycle arrest and inhibits invasion in hepatocellular carcinoma
• Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets
• Novel lawsone-containing ruthenium(II) complexes: synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells
• p-Synephrine induces transcriptional changes via the cAMP/PKA pathway but not cytotoxicity or mutagenicity in human gastrointestinal cells
• Effects of sulforaphane on the oxidative response, apoptosis, and the transcriptional profile of human stomach mucosa cells in vitro
• Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells
• Analysis of the cytotoxic, genotoxic, mutagenic, and pro-oxidant effect of synephrine, a component of thermogenic supplements, in human hepatic cells in vitro