Low-Level Laser Therapy for osteoradionecrosis management: a scoping review (2024)
- Authors:
- Autor USP: GALLO, CAMILA DE BARROS - FO
- Unidade: FO
- Assunto: LASER NÃO CIRÚRGICO
- Language: Português
- Abstract: This scoping review aimed to explore the impact of Low-Level Laser therapy (LLLT) on osteoradionecrosis (ORN) management. The search strategy was conducted in three databases (PubMed/MEDLINE, EMBASE, and Web of Science Core Collection) and grey literature up to January 15th, 2024. Nineteen studies (6 in vivo studies, 11 case reports, and 2 systematic reviews) were included, without language or time restrictions. The frequency of LLLT use was 58% for therapeutic purposes, 21% for preventive, and 21% for both. Forty-one (41%) of the studies employed antimicrobial photodynamic therapy (aPDT), which utilized methylene blue as the photosensitizer. Photobiomodulation therapy (PBMT) was combined with pharmacological treatment (57%), surgical treatment (29%), antiseptic mouthwashes (11%), and other therapies (4%). The majority of in vivo studies used diode lasers emitting low incident power densities in the near-infrared waveband (67%) at 780 to 904 nm, while case reports used both red and near-infrared waveband (64%) at 660 to 904 nm. The continuous emission mode was utilized in 83% of in vivo studies, however just in 17% of case reports. None of the studies included in this review reported all LLLT parameters. Overall, the studies conclude that laser therapy stimulates bone repair and reduces ionizing radiation damage, with potential indications to treat and prevent ORN. Incomplete data on laser parameters and a lack of clinical studies hinder standardized treatment protocols. There was significant heterogeneity in study design, laser parameters, administration protocols, and interventions in the control groups. Therefore, more studies with homogeneous methodologies are necessary to improve and enhance the efficacy of LLLT in ORN
- Imprenta:
- Source:
- Título: Brazilian Oral Research
- ISSN: 1807-3107
- Volume/Número/Paginação/Ano: v. 38, supl. 1, res. RCR098, 2024
- Conference titles: Proceedings of the SBPqO Annual Meeting
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ABNT
DI CARVALHO MELO L, et al. Low-Level Laser Therapy for osteoradionecrosis management: a scoping review. Brazilian Oral Research. São Paulo: SBPqO. . Acesso em: 28 dez. 2025. , 2024 -
APA
Di Carvalho Melo L,, Bastos Silveira, B., Monteiro, M. M., Amorim dos Santos, J., Ferreira, E. B., Reis, P. E. D., et al. (2024). Low-Level Laser Therapy for osteoradionecrosis management: a scoping review. Brazilian Oral Research. São Paulo: SBPqO. -
NLM
Di Carvalho Melo L, Bastos Silveira B, Monteiro MM, Amorim dos Santos J, Ferreira EB, Reis PED, Gallo C de B, Guerra ENS. Low-Level Laser Therapy for osteoradionecrosis management: a scoping review. Brazilian Oral Research. 2024 ; 38[citado 2025 dez. 28 ] -
Vancouver
Di Carvalho Melo L, Bastos Silveira B, Monteiro MM, Amorim dos Santos J, Ferreira EB, Reis PED, Gallo C de B, Guerra ENS. Low-Level Laser Therapy for osteoradionecrosis management: a scoping review. Brazilian Oral Research. 2024 ; 38[citado 2025 dez. 28 ] - Photobiomodulation is effective in oral lichen planus: a randomized, controlled, double-blind study
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