TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement (2021)
- Authors:
- Vicente, Larissa Gaioto de
- Muñoz, Vitor Rosetto
- Pinto, Ana Paula

- Rovina, Rafael Lemes

- Rocha, Alisson Luiz da

- Marafon, Bruno Brieda

- Tavares, Maria Eduarda de Almeida
- Teixeira, Giovana Rampazzo
- Ferrari, Gustavo Duarte
- Alberici, Luciane Carla

- Frantz, Fabiani Gai

- Simabuco, Fernando Moreira
- Ropelle, Eduardo Rochete
- Moura, Leandro Pereira de
- Cintra, Dennys Esper
- Pauli, José Rodrigo
- Silva, Adelino Sanchez Ramos da

- USP affiliated authors: ALBERICI, LUCIANE CARLA - FCFRP ; FRANTZ, FABIANI GAI - FCFRP ; SILVA, ADELINO SANCHEZ RAMOS DA - EEFERP ; VICENTE, LARISSA GAIOTO DE - FMRP ; MUÑOZ, VITOR ROSETTO - EEFERP ; PINTO, ANA PAULA - EEFERP ; ROVINA, RAFAEL LEMES - EEFERP ; ROCHA, ALISSON LUIZ DA - FMRP ; MARAFON, BRUNO BRIEDA - EEFERP ; FERRARI, GUSTAVO DUARTE - FMRP
- Unidades: FCFRP; EEFERP; FMRP
- DOI: 10.1016/j.lfs.2021.119988
- Subjects: BIOINFORMÁTICA; COMPUTAÇÃO APLICADA
- Keywords: Bioinformatics; Knockout model; Molecular signaling pathways; Morphofunctional characteristics; Regular exercise
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher place: Philadelphia
- Date published: 2021
- Source:
- Título: Life Sciences
- ISSN: 0024-3205
- Volume/Número/Paginação/Ano: v. 285, art. 119988, p. 1-10, 2021
- Este periódico é de assinatura
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: bronze
- Licença: publisher-specific-oa
-
ABNT
VICENTE, Larissa Gaioto de et al. TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement. Life Sciences, v. 285, p. 1-10, 2021Tradução . . Disponível em: https://doi.org/10.1016/j.lfs.2021.119988. Acesso em: 28 dez. 2025. -
APA
Vicente, L. G. de, Muñoz, V. R., Pinto, A. P., Rovina, R. L., Rocha, A. L. da, Marafon, B. B., et al. (2021). TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement. Life Sciences, 285, 1-10. doi:10.1016/j.lfs.2021.119988 -
NLM
Vicente LG de, Muñoz VR, Pinto AP, Rovina RL, Rocha AL da, Marafon BB, Tavares ME de A, Teixeira GR, Ferrari GD, Alberici LC, Frantz FG, Simabuco FM, Ropelle ER, Moura LP de, Cintra DE, Pauli JR, Silva ASR da. TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement [Internet]. Life Sciences. 2021 ; 285 1-10.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1016/j.lfs.2021.119988 -
Vancouver
Vicente LG de, Muñoz VR, Pinto AP, Rovina RL, Rocha AL da, Marafon BB, Tavares ME de A, Teixeira GR, Ferrari GD, Alberici LC, Frantz FG, Simabuco FM, Ropelle ER, Moura LP de, Cintra DE, Pauli JR, Silva ASR da. TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement [Internet]. Life Sciences. 2021 ; 285 1-10.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1016/j.lfs.2021.119988 - Tlr4 participates in the responses of markers of apoptosis, inflammation, and ER stress to different acute exercise intensities in mice hearts
- Hepatic LC3 II/I ratio is not modulated in exercised mice
- Genetic deletion of IL‐6 increases CK‐MB, a classic cardiac damage marker, and decreases UPRmt genes after exhaustive exercise
- Rapamycin did not prevent the excessive exercise-induced hepatic fat accumulation
- Impact of different physical exercises on the expression of autophagy markers in mice
- Role of TLR4 in physical exercise and cardiovascular diseases
- IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise
- One bout of aerobic exercise can enhance the expression of Nr1d1 in oxidative skeletal muscle samples
- Moderate, but not excessive, training attenuates autophagy machinery in metabolic tissues
- Muscle endoplasmic reticulum stress in exercise
Informações sobre o DOI: 10.1016/j.lfs.2021.119988 (Fonte: oaDOI API)
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